Browse our FGFR3 Proteins (FGFR3)

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

• fibroblast growth factor receptor 3 (FGFR3)
• fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog (fgfr3.S)
• fibroblast growth factor receptor 3 (Fgfr3)
• fibroblast growth factor receptor 3 (fgfr3)

• ACH protein
• CD333 protein
• CEK2 protein
• fc27h01 protein
• Fgfr-3 protein
• Show all synonym aliases
• FGFR3 protein
• Flg-2 protein
• FR3 protein
• HBGFR protein
• HSFGFR3EX protein
• JTK4 protein
• LOC100034114 protein
• Mfr3 protein
• sam3 protein
• wu:fc27h01 protein

fibroblast growth factor receptor 3 , FGFR-3 , fibroblast growth factor receptor 3 variant 4 , hydroxyaryl-protein kinase , tyrosine kinase JTK4 , heparin-binding growth factor receptor , fibroblast growth factor receptor 3-IIIc , tyrosine kinase (cek2) , tyrosine kinase receptor CEK2 , fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)