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Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
functional clathrin-mediated endocytosis is required for proper FGFR4 signaling
The frequent expression of members of the FGFR (show FGFR2 Proteins) family in cervical cancer suggests they may have prognostic and therapeutic relevance.
The frequency of the FGFR4 Arg388 (A) allele was significantly higher in hypertensive subjects (36%) than controls (24.3%). GA,AA, and GA+AA genotypes were significantly associated with risk of hypertension, even after adjusting for age, body mass index, and glucose. Gender stratification showed a significant association only in female subjects. Subjects with GA and AA genotypes showed higher diastolic blood pressure.
Enhanced myocardial expression of FGFR4 is associated with left ventricular hypertrophy in chronic kidney disease.
These observations suggest a crucial role for cancer-associated fibroblasts and fibroblast growth factor-1 (show FGF1 Proteins)/fibroblast growth factor receptor 4 signaling in the progression of ovarian cancer. the expression level of Snail1 (show SNAI1 Proteins) and MMP3 (show MMP3 Proteins) was reduced, while the expression level of E-cadherin (show CDH1 Proteins) increased
High FGFR4 expression was significantly associated with the depth of invasion, lymph-node metastasis, pathological stage, and distant metastasis or recurrent disease in gastric cancer.
This study showed that Gly388Arg FGFR4 Polymorphism Is Not Predictive of Everolimus Efficacy in Well-Differentiated Digestive Neuroendocrine Tumors.
Data suggest that knockdown of fibroblast growth factor receptor 4 (FGFR4) expression might prevent the growth of astric cancer (GC) in vivo.
FGFR4 is overexpressed in oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC) in the absence of gene amplification, and may serve as a potential predictive marker for FGFR4-directed targeted therapy in OSCC and OPSCC.
analysis of FGFR3 (show FGFR3 Proteins) and FGFR4 gene polymorphisms in breast cancer in Chinese women of Heilongjiang province reveals that SNPs rs1966265 and rs351855 in FGFR4 , but not rs2234909 and rs3135848 in FGFR3 (show FGFR3 Proteins) are associated with breast cancer
Blocking FGFR4 inhibits cardiac calcineurin/NFAT (show NFATC1 Proteins) signaling and attenuates the development of LVH and cardiac fibrosis in a well-established animal model of CKD without significantly altering kidney function, blood pressure, or FGF23 (show FGF23 Proteins) levels.
The FGFR4 transmembrane polymorphic variants can modulate cellular growth and sensitivity to glucocorticoid hormone negative feedback.
FGFR4 deficiency in mice leads to improvement in glucose metabolism, insulin (show INS Proteins) sensitivity, and reduction in body weight under high fat conditions.
The FGFR4-R388 allele yields a receptor variant that preferentially promotes STAT3 (show STAT3 Proteins)/5 signaling.
study shows FGFR4 is specifically up regulated by PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins); however this FGFR4 over expression does not contribute to PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins) tumorigenic phenotypes in primary skeletal muscle myoblasts
findings suggest a modulatory role for FGFR4 in the development and progression of hepatocellular carcinoma and that FGFR4 may be an important and novel therapeutic target in treating this disease
Differential specificity of endocrine FGF19 (show FGF19 Proteins) and FGF21 (show FGF21 Proteins) to FGFR1 (show FGFR1 Proteins) and FGFR4 in complex with KLB (show KLB Proteins).
FGFR3 (show FGFR3 Proteins) and 4 are the receptors that regulate serum 1,25(OH)(2)Vitamin D(3) levels in response to FGF23 (show FGF23 Proteins).
FGFR4 activation mediates the induction of hepatocyte proliferation and the suppression of bile acid biosynthesis by FGF19 (show FGF19 Proteins).
These studies suggest that FGFR1 (show FGFR1 Proteins), FGFR3 (show FGFR3 Proteins), and FGFR4 act in concert to mediate FGF23 (show FGF23 Proteins) effects on the kidney and that loss of FGFR (show FGFR2 Proteins) function leads to feedback stimulation of Fgf23 (show FGF23 Proteins) expression in bone
Fgfr4 mediates a signal-transduction pathway between Wnt16 (show WNT16 Proteins) and Dlc, but not Dld, to regulate haematopoietic stem cells specification.
The analysis of receptor-ligand interactions between D. rerio fgf8 (show FGF8 Proteins) and its receptors, fgfr1 (show FGFR1 Proteins) and fgfr4, using combined spectroscopy methods are reported.
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
fibroblast growth factor receptor 4
, FGF receptor 4
, hydroxyaryl-protein kinase
, protein-tyrosine kinase
, tyrosine kinase related to fibroblast growth factor receptor
, tyrosylprotein kinase
, CTLA-2-beta protein
, fibroblast growth factor receptor 4 16 minus form
, protein-tyrosine kinase receptor MPK-11
, fibroblast growth factor receptor FREK
, fibroblast growth factor receptor-like embryonic kinase
, fibroblast growth factor receptor 4c