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Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
Our data indicate that FGFR4 polymorphic isoforms mediate signaling that yields mitochondrial therapeutic targets of relevance to the actions of different somatostatin (show SST Proteins) analogs.
In radiosensitive SW480 and DLD1 cells, enforced expression of FGFR4 stabilized RAD51 (show RAD51 Proteins) protein levels resulting in enhanced clearance of gamma-H2AX (show H2AFX Proteins) foci and increased cell survival in the mismatch repair (MMR (show MRC1 Proteins))-proficient SW480 cells.
FGFR4/FGF19 (show FGF19 Proteins) autocrine signaling mediates the survival of a subset of basal-like breast cancer cells
Study shows that loss of FGFR4 expression led to a remarkable increase in sorafenib-induced ROS (show ROS1 Proteins) generation and apoptosis of hepatocellular carcinoma (HCC (show FAM126A Proteins)) cell lines, and demonstrates that hyperactivation of FGF19 (show FGF19 Proteins)/FGFR4 signaling in HCC (show FAM126A Proteins) is one of the main mechanisms of sorafenib resistance.
This is the first study to elucidate FGF19 (show FGF19 Proteins)/FGFR4 signaling in favor of hepatocellular carcinoma cells developing from fatty liver
High expression of FGFR4 is associated with hepatocellular carcinoma.
Findings show that FGF19 (show FGF19 Proteins) provides a cytoprotective role against ER stress by activating a FGFR4-GSK3beta-Nrf2 (show GABPA Proteins) signaling cascade, suggesting targeting this signaling node as a candidate therapeutic regimen for hepatocellular carcinoma (HCC (show FAM126A Proteins)) management.
FGF23 (show FGF23 Proteins) augments pro-fibrotic signalling cascades in injury-primed renal fibroblasts via activation of FGFR4
functional clathrin-mediated endocytosis is required for proper FGFR4 signaling
The frequent expression of members of the FGFR (show FGFR2 Proteins) family in cervical cancer suggests they may have prognostic and therapeutic relevance.
The findings suggest that the primary role of Fgfr3 (show FGFR3 Proteins) and Fgfr4 is to control the orderly formation of elastin (show ELN Proteins) fibers. In a normal lung, FGFR3 (show FGFR3 Proteins) and FGFR4 restrict the expression of MFAP5 (show MFAP5 Proteins), among other elastogenesis factors.
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
Blocking FGFR4 inhibits cardiac calcineurin/NFAT (show NFATC1 Proteins) signaling and attenuates the development of LVH and cardiac fibrosis in a well-established animal model of CKD without significantly altering kidney function, blood pressure, or FGF23 (show FGF23 Proteins) levels.
The FGFR4 transmembrane polymorphic variants can modulate cellular growth and sensitivity to glucocorticoid hormone negative feedback.
FGFR4 deficiency in mice leads to improvement in glucose metabolism, insulin (show INS Proteins) sensitivity, and reduction in body weight under high fat conditions.
The FGFR4-R388 allele yields a receptor variant that preferentially promotes STAT3 (show STAT3 Proteins)/5 signaling.
study shows FGFR4 is specifically up regulated by PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins); however this FGFR4 over expression does not contribute to PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins) tumorigenic phenotypes in primary skeletal muscle myoblasts
findings suggest a modulatory role for FGFR4 in the development and progression of hepatocellular carcinoma and that FGFR4 may be an important and novel therapeutic target in treating this disease
Differential specificity of endocrine FGF19 (show FGF19 Proteins) and FGF21 (show FGF21 Proteins) to FGFR1 (show FGFR1 Proteins) and FGFR4 in complex with KLB (show KLB Proteins).
Fgfr4 mediates a signal-transduction pathway between Wnt16 (show WNT16 Proteins) and Dlc, but not Dld, to regulate haematopoietic stem cells specification.
The analysis of receptor-ligand interactions between D. rerio fgf8 (show FGF8 Proteins) and its receptors, fgfr1 (show FGFR1 Proteins) and fgfr4, using combined spectroscopy methods are reported.
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
fibroblast growth factor receptor 4
, FGF receptor 4
, hydroxyaryl-protein kinase
, protein-tyrosine kinase
, tyrosine kinase related to fibroblast growth factor receptor
, tyrosylprotein kinase
, CTLA-2-beta protein
, fibroblast growth factor receptor 4 16 minus form
, protein-tyrosine kinase receptor MPK-11
, fibroblast growth factor receptor FREK
, fibroblast growth factor receptor-like embryonic kinase
, fibroblast growth factor receptor 4c