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anti-Human Galectin 3 Antibodies:
anti-Rat (Rattus) Galectin 3 Antibodies:
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Human Polyclonal Galectin 3 Primary Antibody for CyTOF, FACS - ABIN4899436
Thijssen, Hulsmans, Griffioen: The galectin profile of the endothelium: altered expression and localization in activated and tumor endothelial cells. in The American journal of pathology 2008
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Human Monoclonal Galectin 3 Primary Antibody for IHC (f), ICS - ABIN2689513
Cherayil, Weiner, Pillai: The Mac-2 antigen is a galactose-specific lectin that binds IgE. in The Journal of experimental medicine 1990
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Human Monoclonal Galectin 3 Primary Antibody for Func, IA - ABIN2192045
Liu, Hsu, Zuberi, Hill, Shenhav, Kuwabara, Chen: Modulation of functional properties of galectin-3 by monoclonal antibodies binding to the non-lectin domains. in Biochemistry 1996
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Human Polyclonal Galectin 3 Primary Antibody for IF (p), IHC (p) - ABIN672321
Lee, Bae, Choi, Park, Chun: Molecular cloning and expression analysis of pig CD7. in Veterinary research communications 2014
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Human Monoclonal Galectin 3 Primary Antibody for ELISA, FACS - ABIN152697
Staels, Rubenstrunk, Noel, Rigou, Delataille, Millatt, Baron, Lucas, Tailleux, Hum, Ratziu, Cariou, Hanf: Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. in Hepatology (Baltimore, Md.) 2013
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Mouse (Murine) Monoclonal Galectin 3 Primary Antibody for FACS - ABIN4896110
Ansa-Addo, Lange, Stratton, Antwi-Baffour, Cestari, Ramirez, McCrossan, Inal: Human plasma membrane-derived vesicles halt proliferation and induce differentiation of THP-1 acute monocytic leukemia cells. in Journal of immunology (Baltimore, Md. : 1950) 2010
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Cow (Bovine) Polyclonal Galectin 3 Primary Antibody for IHC, WB - ABIN2785832
Bartolazzi, Orlandi, Saggiorato, Volante, Arecco, Rossetto, Palestini, Ghigo, Papotti, Bussolati, Martegani, Pantellini, Carpi, Giovagnoli, Monti, Toscano, Sciacchitano, Pennelli, Mian, Pelizzo, Rugge, Troncone, Palombini, Chiappetta, Botti, Vecchione, Be: Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study. in The lancet oncology 2008
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Human Polyclonal Galectin 3 Primary Antibody for WB - ABIN517489
Shi, Tan, Meng, Yu, Li, Yin, Wei, Luo, Jia, Zhang, Wu, Mi, Wang: Association of anti-acidic ribosomal protein P0 and anti-galectin 3 antibodies with the development of skin lesions in systemic lupus erythematosus. in Arthritis & rheumatology (Hoboken, N.J.) 2014
Mouse (Murine) Polyclonal Galectin 3 Primary Antibody for IHC, WB - ABIN5663915
Sun, Li, Yang, Shan, Zhang, Huang: G3-C12 Peptide Reverses Galectin-3 from Foe to Friend for Active Targeting Cancer Treatment. in Molecular pharmaceutics 2016
Human Polyclonal Galectin 3 Primary Antibody for IHC (p), WB - ABIN657647
Salomonsson, Carlsson, Osla, Hendus-Altenburger, Kahl-Knutson, Oberg, Sundin, Nilsson, Nordberg-Karlsson, Nilsson, Karlsson, Rini, Leffler: Mutational tuning of galectin-3 specificity and biological function. in The Journal of biological chemistry 2010
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Demonstrate that galectin-3 plays a critical role in hensin ECM assembly by oligomerizing secreted monomeric hensin.
Exosomes Derived from HIV-1 Infected DCs Mediate Viral trans-Infection via Fibronectin and Galectin-3.
Gal-1 and Gal-3 through their binding partners may form a supramolecular structure at the cell surface of fibroblasts, immune cells, endothelial cells, and in the extracellular space that might influence the fibroblast morphology, adhesion, proliferation, migration, and survival as well as the inflammatory responses.
Data found that pathological B-cells from patients with chronic lymphocytic leukemia (CLL) exhibit increased expression of Gal-3. Moreover, the study suggests that the highest expression of Gal-3 is associated with 17p deletion in CLL.
promotes cancer cell adhesion to vascular endothelial cells by increasing the expression of N-cadherin and CD44 via an increase of beta-catenin nuclear accumulation
Our results suggest a direct role for Gal-3 in Paracoccidioides brasiliensis infection, with beneficial effects for the mammalian host.
Increased circulating Gal3 is associated with increased 12 months cumulative cardiovascular events among patients with documented non-Hodgkin lymphoma.
Galectin-1 and galectin-3 are overexpressed in renal cell carcinoma with different percentage in different subtypes
hibition of Galectin-3 gene expression in oral squamous cell carcinoma can significantly reduce the proliferation and invasion of cancer cells and induce apoptosis. The mechanism is related to downregulation of the Wnt/beta-catenin signaling pathway.
Rs2274273 and rs17128183 rare allele bearing genotypes, according to the dominant model (CT+TT vs. CC and AG+GG vs. AA, respectively), were significantly and independently associated with maladaptive LVR (adjusted OR = 3.02, P = 0.016; adjusted OR = 3.14, P = 0.019, respectively) and higher LGALS-3 mRNA expression
galectin-3C enhances galectin-3 binding to neutrophils by nonactivating type-C self-association, in parallel to inhibiting neutrophil activation by galectin-3 (induced by type-N self-association).
Galectin-3 plays a role in the systemic immune system response against Helicobacter pylori (Hp,) potentiating its deleterious effect in areas distant from gastrointestinal tract colonization and may contribute to triggering CNS inflammation and/or neurodegeneration.
Pull-down assays, gel filtration, and biolayer interferometry further demonstrate that galectin-3 binds to the CD146 ectodomain (eFL) with a KD of ~1.1 mum.
Gal-3 contributes to the pathogenesis of ocular allergy and represents a relevant therapeutic target.
findings increase understanding as to how galactans interact with Gal-3 at the non-reducing, terminal end of galactose-containing polysaccharides as found on the cell surface.
Low galectin 3 expression is associated with Thyroid Papillary Carcinoma.
Data indicate a high expression of galectin-9 (Gal-9) in pancreatic ductal adenocarcinoma (PDAC) serum and tissue.
The TGF-beta-induced epithelial-mesenchymal transition in A549 cells can be enhanced by Galectin3.
Study report that galectin3 expression is upregulated in nonsmall cell lung cancer cells under hypoxia and that it contributes to tumor cell migration and invasion. Cell motility is upregulated by the function of activated RhoA, which is induced by high levels of cytoplasmic galectin3.
Serum galectin-3 is independently associated with progressive renal disease in type 2 diabetes
Galectin-3 levels independently predict outcomes in patients with reduced left ventricular systolic function addressed for ablation of persistent atrial fibrillation, and may be of interest in defining the therapeutic strategy in this population.
Mutational tuning of galectin-3 specificity and biological function.
The overall findings suggest that the secreted galectin-3 stimulated by PGF plays a role in structural luteolysis by binding to beta 1 integrin.
The relative abundance of PIBF, LGALS1, LGALS3, LGALS3BP, and LGALS9 mRNA would display a differential expression pattern in the endometrium.
this study shows that galectin-3 deficiency enhances type 2 immune cell-mediated myocarditis in mice
Mice lacking galectin-3 (Lgals3) function have decreased home cage movement
endogenous galectin-3 enhances the effects of H5N1 infection by promoting host inflammatory responses and regulating IL-1beta production by macrophages via interaction with NLRP3.
this study shows that decrease of galectin-3 in keratinocytes is a potential diagnostic marker and a critical contributor to the pathogenesis of psoriasis
Compared with WT mice, Gal-3 KO mice have more germinal centers B cells and T follicular helper cells, increased percentages of antibody-secreting cells and higher concentrations of immunoglobulins and IFN-gamma in serum, and develop a lupus-like disease.
Evidence for a contribution of galectin-3 to bone cell maturation and function, bone remodeling, and biomechanical competence, thus identifying galectin-3 as a promising therapeutic target for age-related disorders of bone remodeling.
Robust upregulation of cardiac galectin-3 (Gal-3) expression in a mouse model of cardiomyopathy attributable to cardiomyocyte-restricted transgenic activation of beta2-adrenoceptors may not be a critical disease mediator of cardiac remodeling in this model.
It has been reported that the Galectin-3/NuMA interaction is functionally important for the spindle pole organization; spindle pole cohesion requires glycosylation-mediated localization of NuMA.
Galectin-3 suppresses antibacterial autophagy through a host N-glycan-dependent mechanism in Listeria-infected macrophages. Knock out of the galectin-3 gene resulted in enhanced LC3 recruitment to Listeria and decreased bacterial replication.
Study shows that potent pro-inflammatory and pro-fibrotic molecules, osteopontin and galectin-3, are not major disease modulators of laminin alpha2 chain-deficient muscular dystrophy.
These results suggest that following head trauma, released galectin-3 may act as an alarmin, binding, among other proteins, to TLR-4 and promoting inflammation and neuronal loss.
Gal-3 and nSMase, by inducing thyroid changes, might be the cause of the increased expression and altered distribution of TSH, thyroglobulin, and TSHR or vice-versa.
Stroke (after left sided permanent middle cerebral artery occlusion) triggers central and peripheral galectin-3 release causing enteric neuronal loss through a TLR4 mediated mechanism involving TAK1 and AMPK.
the secretion of galectin-3 as a novel mechanism for osteoblasts to control osteoclastogenesis and to maintain trabecular bone homeostasis independently of the RANKL/OPG-axis.
Our findings establish gal-3 as a molecular regulator of the JAG1/Notch-1 signaling pathway and have direct implications for the development of strategies aimed at controlling tumor angiogenesis.
Mycobacerium PtkA downregulates host Galectin 3, which is an anti-apoptotic molecule.
Antilymphoma activity by M(IFN-gamma/LPS) macrophages was mediated, in part, by galectin-3. Intriguingly, aggressive lymphoma growth was markedly impaired in mice deficient in galectin-3, suggesting either that host galectin-3-mediated antilymphoma activity is required to sustain net tumor growth or that additional functions of galectin-3 drive key oncogenic mechanisms in non-Hodgkin's lymphoma.
galectin-3 is dynamically overexpressed in response to acute myocardial infarction-induced cardiac remodelling.
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.
35 kDa lectin
, beta-galactosides-binding lectin
, carbohydrate-binding protein 35
, galactose-specific lectin 3
, igE-binding protein
, laminin-binding protein
, lectin L-29
, lectin, galactoside-binding, soluble, 3 (galectin 3)
, mac-2 antigen
, 3 (galectin 3)
, CBP 35
, IgE-binding protein
, MAC-2 antigen
, lectin, galactoside-binding, soluble, 3
, galectin 3
, IgE binding protein
, lectin, galactose binding, soluble 3
, L-34 galactoside-binding lectin