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Human Polyclonal GAS6 Primary Antibody for IHC, IHC (p) - ABIN4313581
Pinato, Mauri, Lloyd, Vaira, Casadio, Boldorini, Sharma: The expression of Axl receptor tyrosine kinase influences the tumour phenotype and clinical outcome of patients with malignant pleural mesothelioma. in British journal of cancer 2013
Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 signaling.
This study demonstrated that the Gas6(-/-) Axl (show AXL Antibodies)(-/-) double knockout (DKO) mice showed axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure.
The possibility that the Gas6-Mer (show ERH Antibodies)-PI3K/Akt (show AKT1 Antibodies)-STAT1 (show STAT1 Antibodies)-LXR (show NR1H3 Antibodies)-Arg2 (show ARG2 Antibodies) pathway plays an essential role for resolving inflammatory response in acute lung injury.
Taken together, in our study Gas6 fails to aggravate calcification against the previous assumption.
The present study provides evidence that the vitamin K-dependent protein growth arrest specific 6 (Gas6) promotes such repair in in vitro cultures of mouse optic nerve and cerebellum.
Gas6 specifically promotes the recruitment of inflammatory CCR2 (show CCR2 Antibodies)(hi)CX3CR1 (show CX3CR1 Antibodies)(lo) monocytes through the regulation of both CCR2 (show CCR2 Antibodies) and CCL2 (show CCL2 Antibodies) during deep venous thrombosis.
Gas6/Axl (show AXL Antibodies) and Akt (show AKT1 Antibodies)/FoxO1a (show FOXO1 Antibodies) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Gas6-mediated uptake is not a means to clear the bulk of circulating membrane-derived microparticles (PMPs) but may serve to locally phagocytose PMPs generated at sites of platelet activation and as a way to effect endothelial responses.
Gas6-FoxO-1 (show FOXO1 Antibodies) signaling axis plays an important role in VCAM-1 (show VCAM1 Antibodies) expression in the context of venous thromboembolism by promoting bone marrow mononuclear cell-endothelial cell adhesion.
Gas6 and Axl (show AXL Antibodies) serum levels increase in parallel to chronic liver disease progression inactivation.
Gas6, through upregulation of Ptges (show PTGES Antibodies)/PGE2, contributes to cancer-induced venous thrombosis.
Self-sustaining cells are characterized by excessive GAS6 secretion and TAM (show CCNA1 Antibodies)-PDK (show PDK2 Antibodies)-RSK (show RPS6KA1 Antibodies)-mTOR (show FRAP1 Antibodies) pathway activation.
The anti-angiogenic effect of luteolin may be associated with the inhibition of the Gas6/Axl (show AXL Antibodies) pathway and its downstream phosphatidylinositol 3-kinase (PI3K (show PIK3CA Antibodies))/protein kinase B (Akt (show AKT1 Antibodies))/mammalian target of rapamycin (mTOR (show FRAP1 Antibodies)) signaling pathways.
TWIST1 (show TWIST1 Antibodies), in part via GAS6 and L1CAM (show L1CAM Antibodies), led to higher expression and activation of Akt (show AKT1 Antibodies) upon cisplatin treatment, and inhibition of Akt (show AKT1 Antibodies) activation sensitized cells to cisplatin.
Gas6 bound to the fiber proteins of adenovirus and suppressed IFN beta (show IFNB1 Antibodies) production.
Protein S and Gas6 mediates phagocytosis of HIV-1-infected cells by bridging receptor tyrosine kinase (show RET Antibodies) Mer (show MERTK Antibodies) to phosphatidylserine exposed on infected cells.
A critical role for GAS6 in epithelial cells in maintaining oral homeostasis.
AXL (show AXL Antibodies) is the only relevant Zika virus entry cofactor expressed on fetal endothelial cells, and that when produced in mammalian cells, only Zika virus, but not West Nile virus or dengue virus, can use AXL (show AXL Antibodies), because it more efficiently binds Gas6.
The plasma concentrations of Gas6 and Axl (show AXL Antibodies) are lowered in rheumatoid arthritis patients.
Suppression of AXL by shRNA and inhibitor prolonged survival of chronic myelogenous leukemia (CML) mice and reduced the growth of leukemia stem cells ( LSCs) in mice. Gas6/AXL ligation stabilizes beta-catenin in an AKT-dependent fashion in human CML CD34(+) cells. Our findings improve the understanding of LSC regulation and validate Gas6/AXL as a pair of therapeutic targets to eliminate CML LSCs
AXL (show AXL Antibodies)+ and GAS6+ expression is relevant to a poor prognosis in resected lung adenocarcinoma (AD)patients at stage I. AXL (show AXL Antibodies)/GAS6 might serve as crucial predictive and prognostic biomarkers and targets to identify individuals at high risk of post-operative death.
The results imply that the GAS6 gene can be considered a potential candidate for meat quality trait selection and fat deposition in pigs.
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth arrest specific 6
, growth arrest-specific protein 6
, growth arrest-specific 6
, growth arrest-specific protein 6-like
, AXL receptor tyrosine kinase ligand
, GAS 6
, growth-potentiating factor
, AXL stimulatory factor