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Human PDGFA Protein expressed in Wheat germ - ABIN1314496
Paule, Nebl, Webb, Vollenhoven, Rombauts, Nie: Proprotein convertase 5/6 cleaves platelet-derived growth factor A in the human endometrium in preparation for embryo implantation. in Molecular human reproduction 2015
Zebrafish pdgf-a mRNA was present at high levels in fertilized eggs as well as in all embryonic cells up to the end of gastrulation
PDGF-A signaling is involved in myofibroblast proliferation and migration.
These studies uncover PI3K/AKT2 (show AKT2 Proteins) as a direct PDGFA target that is activated in adipocyte stem cells.
stronger fibrotic effect generated by Platelet-derived growth factor alpha overexpression was mediated by Platelet-derived growth factor receptor (show PDGFRB Proteins) alphalpha in cardiac interstitial mesenchymal cells
PDGF-AA impairs endothelium-dependent vasodilation and PDGF-AA mediates BMP4 (show BMP4 Proteins)-induced adverse effect on endothelial cell function through SMAD1 (show SMAD1 Proteins)/5- and SMAD4 (show SMAD4 Proteins)-dependent mechanisms.
Both cell proliferation and hair inductive activity in murine DPCs are maintained by the synergistic effect of fibroblast growth factor 2 (show FGF2 Proteins) and platelet-derived growth factor receptor alpha (show PDGFRA Proteins).
Primary high invasive Glioma initiating cells SU3 contribute to transformation of adjacent normal host glial cells in local tumor microenvironment possibly via PDGF/PDGFR (show PDGFRB Proteins) signaling activation.
Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A), a potent chemotactic factor for fibroblasts.
Platelet-derived growth factor mediates interleukin-13 (show IL13 Proteins)-induced collagen I production in mouse airway fibroblasts.
senescent cells have a role in optimal wound healing through secretion of PDGF-AA
leading to a PDGF-responsive SRF-driven transcriptional program in the midface
PDGFA was down-regulated in the malignant Middle Cerebral Artery Infarction.
this study uncovers a novel mechanism of the Nrf2 (show GABPA Proteins)/PDGFA regulatory loop that is crucial for AKT (show AKT1 Proteins)-dependent hepatocellular carcinoma progression
Tumor cell induced mesenchymal stromal cell chemotaxis appears to be mediated through paracrine secretion of PDGF-AA.
PDGFAA in tumor drainage and HER2 (show ERBB2 Proteins) in peripheral vein blood may have roles in synchronous liver metastasis of colorectal cancer
Insulin (show INS Proteins) treatment caused sustained Akt (show AKT1 Proteins) activity, whereas EGF (show EGF Proteins) or PDGF-AA promoted transient signaling; PDGF-BB produced sustained responses at higher concentrations.Transient responses to EGF (show EGF Proteins) were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I (show IGF1 Proteins) caused full Akt (show AKT1 Proteins) activation
these findings suggest that IGFBP-3 (show IGFBP3 Proteins) suppresses transcription of EGR1 (show EGR1 Proteins) and its target genes bFGF (show FGF2 Proteins) and PDGF through inhibiting IGF-1 (show IGF1 Proteins)-dependent ERK (show EPHB2 Proteins) and AKT (show AKT1 Proteins) activation.
Based on a luciferase reporter assay, plateletderived growth factorA (PDGFA) was identified as a direct target gene of miR375. Additionally, overexpression of PDGFA significantly reversed the effect of miR375 on cell migration and invasion in oral squamous cell carcinoma cell.
The highest PDGF AA levels were found in mothers of fetuses with hypoplastic left heart syndrome . These findings may be useful in screening for congenital heart defects (CCHDs) and offer insight into their association with nuchal translucency
Low concentration of PDGF-AB showed synergism with IFN-alpha (show IFNA Proteins) in IFN-beta (show IFNB1 Proteins) and -gamma induction.
downregulated Rab5a (show RAB5A Proteins) led to slowed cell growth, decreased numbers of migrated cells, decreased numbers of cells at the G0G1 phase and a higher apoptosis rate. However, PDGF significantly rescued these phenomena caused by siRNA against Rab5a (show RAB5A Proteins)
PDGF-A/PDGFRalpha signalling as a tissue-autonomous regulator of contact inhibition of locomotion by controlling N-cadherin (show CDH2 Proteins) upregulation during epithelial-to-mesenchymal transition.
When PDGF-A signaling is inhibited, prechordal mesoderm cells fail to orient towards the ectoderm, the endogenous source of PDGF-A, and no longer migrate towards it.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis\; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.
platelet-derived growth factor subunit A
, platelet-derived growth factor alpha polypeptide
, PDGF subunit A
, platelet-derived growth factor A chain
, PDGF A-chain
, platelet-derived growth factor alpha chain
, platelet-derived growth factor alpha isoform 2 preproprotein
, Platelet-derived growth factor A chain
, platelet derived growth factor, alpha
, PDGF-A (S1)
, platelet-derived growth factor A chain long form
, platelet-derived growth factor A chain short form type 1
, platelet-derived growth factor A chain short form type 2
, platelet-derived growth factor A-chain
, platelet-derived growth factor A chain, long form