Browse our PDGFA Proteins (PDGFA)

Human Platelet-Derived Growth Factor alpha Polypeptide (PDGFA) interaction partners

1. High PDGF expression is associated with cardiac fibrosis.

2. Hypomethylation at a CpG site in PDGFA (encoding platelet-derived growth factor alpha) and PDGFA overexpression are both associated with increased T2 diabetes risk, hyperinsulinemia, increased insulin resistance, and increased steatohepatitis risk.

3. PDGFA was down-regulated in the malignant Middle Cerebral Artery Infarction.

4. this study uncovers a novel mechanism of the Nrf2/PDGFA regulatory loop that is crucial for AKT-dependent hepatocellular carcinoma progression

5. Tumor cell induced mesenchymal stromal cell chemotaxis appears to be mediated through paracrine secretion of PDGF-AA.

6. PDGFAA in tumor drainage and HER2 in peripheral vein blood may have roles in synchronous liver metastasis of colorectal cancer

7. Insulin treatment caused sustained Akt activity, whereas EGF or PDGF-AA promoted transient signaling; PDGF-BB produced sustained responses at higher concentrations.Transient responses to EGF were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I caused full Akt activation

8. these findings suggest that IGFBP-3 suppresses transcription of EGR1 and its target genes bFGF and PDGF through inhibiting IGF-1-dependent ERK and AKT activation.

9. Based on a luciferase reporter assay, plateletderived growth factorA (PDGFA) was identified as a direct target gene of miR375. Additionally, overexpression of PDGFA significantly reversed the effect of miR375 on cell migration and invasion in oral squamous cell carcinoma cell.

10. The highest PDGF AA levels were found in mothers of fetuses with hypoplastic left heart syndrome . These findings may be useful in screening for congenital heart defects (CCHDs) and offer insight into their association with nuchal translucency

11. Low concentration of PDGF-AB showed synergism with IFN-alpha in IFN-beta and -gamma induction.

12. downregulated Rab5a led to slowed cell growth, decreased numbers of migrated cells, decreased numbers of cells at the G0G1 phase and a higher apoptosis rate. However, PDGF significantly rescued these phenomena caused by siRNA against Rab5a

13. There are four platelet-derived growth factor (PDGF) genes (PDGFA, PDGFB, PDGFC and PDGFD) that reside on chromosomes 7, 22, 4 and 11.

14. TLR-stimulated pancreatic cancer cells were specifically investigated for activated signaling pathways of VEGF/PDGF and anti-apoptotic Bcl-xL expression as well as tumor cell growth.

15. Nox4 and Duox1/Duox2 mediate redox activation of mesenchymal cell migration by PDGF.

16. In contrast to platelet-derived growth factor, all urokinase isoforms induced secretion of MMP-9 by mesenchymal stromal cells.

17. Normalization of bone marrow microenvironment is paralleled by decreased expression of TIMP and PDGFA.

18. in primary cultures of glioma stemlike cells that EGR1 contributes to stemness marker expression and proliferation by orchestrating a PDGFA-dependent growth-stimulatory loop.

19. These findings implicate DNA hypomethylation as a specific factor in mediating overexpression of genes associated with Biliary Atresia (BA) and identify PDGFA as a new candidate in BA pathogenesis.

20. Human uPAR activation and its association with beta1-integrin are required for PDGF-AB-induced migration.

Zebrafish Platelet-Derived Growth Factor alpha Polypeptide (PDGFA) interaction partners

1. Zebrafish pdgf-a mRNA was present at high levels in fertilized eggs as well as in all embryonic cells up to the end of gastrulation

Mouse (Murine) Platelet-Derived Growth Factor alpha Polypeptide (PDGFA) interaction partners

1. PDGF-A signaling is involved in myofibroblast proliferation and migration.

2. These studies uncover PI3K/AKT2 as a direct PDGFA target that is activated in adipocyte stem cells.

3. stronger fibrotic effect generated by Platelet-derived growth factor alpha overexpression was mediated by Platelet-derived growth factor receptor alphalpha in cardiac interstitial mesenchymal cells

4. PDGF-AA impairs endothelium-dependent vasodilation and PDGF-AA mediates BMP4-induced adverse effect on endothelial cell function through SMAD1/5- and SMAD4-dependent mechanisms.

5. Both cell proliferation and hair inductive activity in murine DPCs are maintained by the synergistic effect of fibroblast growth factor 2 and platelet-derived growth factor receptor alpha.

6. Primary high invasive Glioma initiating cells SU3 contribute to transformation of adjacent normal host glial cells in local tumor microenvironment possibly via PDGF/PDGFR signaling activation.

7. Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A), a potent chemotactic factor for fibroblasts.

8. Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts.

9. senescent cells have a role in optimal wound healing through secretion of PDGF-AA

10. leading to a PDGF-responsive SRF-driven transcriptional program in the midface

11. Platelet-derived growth factor plays an integral role in mediating TGF-beta1-dependent mesenchymal stem cell stiffening.

12. GPIbalpha blockade reverses production of interleukin (IL)-1alpha by microglia in response to cerebral ischemia in animals with Streptococcus pneumoniae infection.

13. these data uncover an early role of PDGF signaling in primitive endoderm cell survival.

14. PDGFA-long isoform plays a critical role in normal development of the lung, intestine, and vertebral column.

15. study examined lung fibroblasts (LF) to learn whether PDGFRalpha expression distinguished a population of precursor cells with enhanced proliferative and migratory capabilities; PDGF-A and Shh both increased cytokinesis and chemotaxis of LF but through different mechanisms

16. our studies establish that loss of SMAD1/5 leads to upregulation of PDGFA in ovarian granulosa cells

17. Nuclear localization of FoxO3a, an important regulator of p27(kip1) gene-expression, correlates with diminished proliferation of the PDGFRalpha-expressing LF subpopulation.

18. PDGF and integrin alphavbeta3 coordinate to have an antagonistic effect in the reactive oxygen species production at focal adhesion sites to regulate cell adhesion and migration.

19. Pdgf signaling potentiates Wnt2-Wnt7b signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung

20. These results suggest that PDGF functions as a positive regulator in the final differentiation phase of tongue muscle cells in mouse embryos.

Xenopus laevis Platelet-Derived Growth Factor alpha Polypeptide (PDGFA) interaction partners

1. PDGF-A/PDGFRalpha signalling as a tissue-autonomous regulator of contact inhibition of locomotion by controlling N-cadherin upregulation during epithelial-to-mesenchymal transition.

2. When PDGF-A signaling is inhibited, prechordal mesoderm cells fail to orient towards the ectoderm, the endogenous source of PDGF-A, and no longer migrate towards it.