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Human PDGFC Protein expressed in Wheat germ - ABIN1314504
Okada, Honda, Campbell, Sakai, Yamashita, Takebuchi, Hada, Shirasaki, Takabatake, Nakamura, Sunagozaka, Tanaka, Fausto, Kaneko: Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development. in Cancer research 2012
There are four platelet-derived growth factor (PDGF (show PDGFA Proteins)) genes (PDGFA (show PDGFA Proteins), PDGFB (show PDGFB Proteins), PDGFC and PDGFD (show PDGFD Proteins)) that reside on chromosomes 7, 22, 4 and 11.
We conclude that PDGF (show PDGFA Proteins)-CC-induced blood-spinal cord barrier dysfunction can contribute to timing of amyotrophic lateral sclerosis onset
High glucose-mediated induction of PDGF-C via ChREBP (show MLXIPL Proteins) in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes.
PDGF-C up-regulation was mediated by the human embryonic lethal abnormal vision-like protein HuR, which stabilizes the PDGF-C transcript by binding to two predicted AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR).
Concomitant upregulation of PDGF-C with VEGF (show VEGFA Proteins) in Glioblastoma tumor cells.
The results indicate that PDGF-C upregulation and calpain-3 (show CAPN3 Proteins) downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins
Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt (show AKT1 Proteins) and Bad phosphorylation.
Data indicate uPA (plau (show PLAU Proteins)) and PAI1 (Serpine1 (show SERPINE1 Proteins)) were up-regulated in human PDGF-C Tg mice, suggesting that uPA (show PRAP1 Proteins) could be compensating for the loss of tissue-type plasminogen activator (tPA (show PLAT Proteins)) activity in PDGF-C Tg; tpa (show PLAT Proteins) KO mice.
High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma.
PDGF-C is both angiogenic and a neuronal survival factor, and it is an important component of neurovascular crosstalk. [Review]
Results provide both in vitro and in vivo evidence that Mac-1 (show ITGAM Proteins) acting together with LRP1 (show LRP1 Proteins) facilitates PDGF (show PDGFA Proteins)-CC activation by thrombolytic tissue plasminogen activator (show PLAT Proteins) in the neurovascular unit. The requirement of both Mac-1 (show ITGAM Proteins) and LRP1 (show LRP1 Proteins) for efficient activation of PDGF (show PDGFA Proteins)-CC by tPA (show PLAT Proteins) provides a novel mechanism that helps limit PDGFRalpha signaling in the neurovascular unit.
PDGF (show PDGFA Proteins)-CC neutralization or deficiency was not associated with preservation or accelerated loss of peritubular capillaries, suggesting no significant pro-angiogenic effects of PDGF (show PDGFA Proteins)-CC during renal fibrosis
heme oxygenase-1 (HMOX1 (show HMOX1 Proteins)) activity is critically required for the vascular protective/survival effect of PDGF (show PDGFA Proteins)-CC.
Studied survival and antiapoptotic effects of PDGF-C on focal retinal lesions in Ccl2 (show CCL2 Proteins)(-/-)/Cx3cr1 (show CX3CR1 Proteins)(-/-) on C57BL/6N [Crb1 (show CRB1 Proteins)(rd8)] (DKO rd8) background mice, a model for progressive and focal retinal degeneration.
loss of FREM1 function promotes epidermal blistering in Fraser syndrome as a consequence of reduced PDGFC activity, in addition to its stabilising role in the basement membrane
Study indicates the role for PDGF-C as a critical regulator of impaired angiogenesis of diabetes.
PDGF-C promotes tumor growth via a growth promoting effect on hepatic stellate cells that is dependent on the presence of functional PAK-2 (show PAK2 Proteins)
Data identified PDGF (show PDGFA Proteins)-CC as an important candidate target gene for antiangiogenic therapy, and PDGF (show PDGFA Proteins)-CC inhibition may be of therapeutic value in treating neovascular diseases.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.
platelet-derived growth factor C
, platelet-derived growth factor, C polypeptide
, spinal cord-derived growth factor
, secretory growth factor-like protein