Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human PDGFC Protein expressed in Wheat germ - ABIN1314504
Okada, Honda, Campbell, Sakai, Yamashita, Takebuchi, Hada, Shirasaki, Takabatake, Nakamura, Sunagozaka, Tanaka, Fausto, Kaneko: Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development. in Cancer research 2012
There are four platelet-derived growth factor (PDGF (show PDGFA Proteins)) genes (PDGFA (show PDGFA Proteins), PDGFB (show PDGFB Proteins), PDGFC and PDGFD (show PDGFD Proteins)) that reside on chromosomes 7, 22, 4 and 11.
We conclude that PDGF (show PDGFA Proteins)-CC-induced blood-spinal cord barrier dysfunction can contribute to timing of amyotrophic lateral sclerosis onset
High glucose-mediated induction of PDGF-C via ChREBP (show MLXIPL Proteins) in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes.
PDGF-C up-regulation was mediated by the human embryonic lethal abnormal vision-like protein HuR, which stabilizes the PDGF-C transcript by binding to two predicted AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR).
Concomitant upregulation of PDGF-C with VEGF (show VEGFA Proteins) in Glioblastoma tumor cells.
The results indicate that PDGF-C upregulation and calpain-3 (show CAPN3 Proteins) downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins
Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt (show AKT1 Proteins) and Bad phosphorylation.
Data indicate uPA (plau (show PLAU Proteins)) and PAI1 (Serpine1 (show SERPINE1 Proteins)) were up-regulated in human PDGF-C Tg mice, suggesting that uPA (show PRAP1 Proteins) could be compensating for the loss of tissue-type plasminogen activator (tPA (show PLAT Proteins)) activity in PDGF-C Tg; tpa (show PLAT Proteins) KO mice.
High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma.
PDGF-C is both angiogenic and a neuronal survival factor, and it is an important component of neurovascular crosstalk. [Review]
PDGF (show PDGFA Proteins)-CC neutralization or deficiency was not associated with preservation or accelerated loss of peritubular capillaries, suggesting no significant pro-angiogenic effects of PDGF (show PDGFA Proteins)-CC during renal fibrosis
heme oxygenase-1 (HMOX1 (show HMOX1 Proteins)) activity is critically required for the vascular protective/survival effect of PDGF (show PDGFA Proteins)-CC.
Studied survival and antiapoptotic effects of PDGF-C on focal retinal lesions in Ccl2 (show CCL2 Proteins)(-/-)/Cx3cr1 (show CX3CR1 Proteins)(-/-) on C57BL/6N [Crb1 (show CRB1 Proteins)(rd8)] (DKO rd8) background mice, a model for progressive and focal retinal degeneration.
loss of FREM1 function promotes epidermal blistering in Fraser syndrome as a consequence of reduced PDGFC activity, in addition to its stabilising role in the basement membrane
Study indicates the role for PDGF-C as a critical regulator of impaired angiogenesis of diabetes.
PDGF-C promotes tumor growth via a growth promoting effect on hepatic stellate cells that is dependent on the presence of functional PAK-2 (show PAK2 Proteins)
Data identified PDGF (show PDGFA Proteins)-CC as an important candidate target gene for antiangiogenic therapy, and PDGF (show PDGFA Proteins)-CC inhibition may be of therapeutic value in treating neovascular diseases.
PDGF-CC is critically required for neuronal survival in both brain and retina. Its neuroprotective effect of PDGF-CC is achieved by regulating GSK3beta phosphorylation and expression.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.
platelet-derived growth factor C
, platelet-derived growth factor, C polypeptide
, spinal cord-derived growth factor
, secretory growth factor-like protein