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PLD2 is involved into pathogenesis of a vast array of human diseases, and as such it can be targeted for therapy. (Review)
Slug is a positive regulator, and Snail (show SNAI1 Proteins) a negative regulator, of PLD2 expression.
Data suggest that elevated membrane tension acts through phospholipase D2 (PLD2) and the mammalian target of rapamycin (show FRAP1 Proteins) complex 2 (mTORC2 (show CRTC2 Proteins)) to limit actin nucleation.
results suggest that the small GTPase (show RACGAP1 Proteins) RalA (show rala Proteins) plays an important role in promoting invagination and trafficking of caveolae, not by potentiating the association between Cav-1 (show CAV1 Proteins) and FilA but by stimulating PLD2-mediated generation of phosphatidic acid.
Suggest PLD expression in high grade serous ovarian carcinoma may have a role in mediating progression to effusions and chemoresistance.
PLD2 functions as a key mediator in the VEGF-mediated angiogenic functions of endothelial cells.
PLD2 protein itself interacts with HIF-1alpha (show HIF1A Proteins), prolyl hydroxylase (PHD (show PDC Proteins)) and VHL (show VHL Proteins) to promote degradation of HIF-1alpha (show HIF1A Proteins) via the proteasomal pathway independent of lipase (show LIPG Proteins) activity.
PLD2-mediated production of phosphatidic acid contributed to the control of EGFR (show EGFR Proteins) exposure to ligand through a multipronged transcriptional and posttranscriptional program during the out-of-control accumulation of EGFR (show EGFR Proteins) signaling in cancer cells.
These results suggest that PLD2 expression in colon cancer cells is up-regulated via HIF1-alpha (show HIF1A Proteins) in response to hypoxic stress and underscores the crucial role of HIF1-alpha (show HIF1A Proteins)-induced PLD2 in tumor growth.
A 3D model of the PLD2 by combining homology and ab initio 3 dimensional structural modeling methods, and docking conformation, is reported.
Results suggest that PLD2 is the isoform that mediates aldosterone secretion and likely priming.
High PLD2 expression is associated with Lung Metastasis of Breast Cancer.
Pld1-/- and Pld2-/- mice present elevated free fatty acids (FFA) levels and are insulin (show INS Proteins) as well as glucose intolerant. In conclusion, these data suggest that deficiency of PLD1 or PLD2 activity promotes development of overweight and diabetes.
PLD1/2 signaling pathways are involved in mitogenic signaling in astrocytes.
Data show that although phospholipase D PLD1 deficiency impaired Fc epsilon receptor FcepsilonRI-mediated signaling and mast cell function, phospholipase D PLD2 deficiency actually enhanced these pathways.
PLD2 in neutrophils is essential for the pathogenesis of experimental sepsis
The impact of polyunsaturated fatty acid (PUFA) supplementation on phospholipase D (PLD) trafficking and activity in mast cells was investigated.
AQP3 (show AQP3 Proteins) has a pro-differentiative role in epidermal keratinocytes and PLD2 activity is necessary for this effect.
phosphatidic acid and phospholipase D1 and D2 have roles in leukocyte adhesion
PLD1 and PLD2 have roles in platelet alpha-granule secretion
The results indicate that PKC (show FYN Proteins) could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase by Ang II (show AGT Proteins).
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.
, phospholipase D2-like
, choline phosphatase 2
, phosphatidylcholine-hydrolyzing phospholipase D2
, PLD 2
, phospholipase D gene 2