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zebrafish HBNF was able to enhance extensive neurite outgrowth in zebrafish embryos during embryogenesis
High PTN and N-syndecan (show SDC3 Proteins) expression was closely associated with metastasis and poor prognosis, suggesting that they may promote tumor progression and perineural invasion in the orthotopic mouse model of pancreatic cancer.
PTN expression in glioma cells is associated with chromosome 7 gain. PTN enhances PDGFB-induced gliomagenesis by stimulating proliferation of neural progenitor cells.
an early extracellular space disruption of PTN composition induces short- and long-term defaults in the establishment of proper functional cerebellar circuit.
NK cells promote fetal development through the secretion of growth-promoting factors, pleiotrophin and osteoglycin (show OGN Proteins).
PTN knockdown attenuated the progression of experimental PVR (show PVR Proteins) in vivo. These findings provide new insights into the pathogenesis of PVR (show PVR Proteins).
Annealing helicase HARP closes RPA-stabilized DNA bubbles non-processively.
Neural precursor cell (NPC (show NPC1 Proteins)):glioma cell communication underpins the propensity of glioma to colonize the lateral ventricle subventricular zone (SVZ) through secretion of chemoattractant signals toward which glioma cells home; analyses of SVZ NPC (show NPC1 Proteins)-secreted factors revealed the neurite outgrowth-promoting factor pleiotrophin, with required SPARC (show SPARC Proteins)/SPARCL1 and HSP90B (show HSP90AB1 Proteins) as mediators of this chemoattractant effect.
these data indicate that PTN-PTPRZ (show PTPRZ1 Proteins)-A signaling controls the timing of oligodendrocyte precursor cell differentiation in vivo, in which the CS moiety of PTPRZ (show PTPRZ1 Proteins) receptors maintains them in a monomeric active state until its ligand binding.
PTN could be considered as a potential biomarker for the presence of breast cancer.
this study shows that the expression of PTN is significantly downregulated in keloid fibroblasts compared to normal human fibroblasts
The data demonstrate that PTN overexpression in the brain blocks the conditioning effects of amphetamine and enhances the characteristic striatal dopaminergic denervation caused by this drug
Ptn may play a vital role in the progesterone-induced decidualization pathway via C/EBPB (show CEBPB Proteins)-cyclic AMP (show TMPRSS5 Proteins)-Hand2 (show HAND2 Proteins) signaling.
The results of this study suggested that regulation of the PTN signaling pathways may constitute new therapeutic opportunities particularly in those neurological disorders characterized by increased PTN cerebral levels and neuroinflammation.
findings link pleiotrophin abundance in gliomas with survival in humans and mice, and show that pleiotrophin promotes glioma progression through increased VEGF (show VEGFA Proteins) deposition and vascular abnormalization.
antagonizes Brd2 (show BRD2 Proteins) promoting cell differentiation associated with the neural tube: spinal cord neurogenesis and neural crest migration
PTN-mediated hematopoietic regeneration occurs in a RAS-dependent manner.
the absence of PTN in vivo is associated with disruption of specific cognitive and affective processes
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation (By similarity).
heparin-binding neurite-promoting factor
, pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
, heparin affin regulatory protein
, heparin binding growth factor 8
, heparin-binding brain mitogen
, heparin-binding growth factor 8
, heparin-binding growth-associated molecule
, heparin-binding neurite outgrowth-promoting factor 1
, neurite growth-promoting factor 1
, osteoblast-specific factor 1
, pleiotrophic factor-beta-1
, heparin-binding neutrophic factor
, heparin affin regulatory peptide
, heparin-binding neurite promoting factor
, heparin-binding neurotorphic factor
, osteoblastic cell factor
, Pleiotrophin (Heparine binding factor, Hbnf, in the mouse)
, heparin binding factor