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Human PPP3CB Protein expressed in Wheat germ - ABIN2801502
Eguchi, Kubo, Ohta, Kunimasa, Okada, Tamaki, Kaji, Wakabayashi, Fujimori, Ogawa: FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway. in Cellular signalling 2013
NFAT is activated through calcineurin and interacts with NFsmall ka, CyrillicB after P. aeruginosa lung infection, and contributes to the host inflammatory response.
CnAbeta1 is mainly localized at the Golgi apparatus through its C-terminal domain. CnAbeta1 is needed for mTORC2 (show CRTC2 Proteins) localization and activation at the cellular membranes. CnAbeta1 regulates differentiation of mouse embryonic stem cells to mesoderm.
Data indicate that calcineurin (CnAalpha-/- or CnAbeta-/-) is required for pathological but not compensatory renal hypertrophy.
CaM plays an active role in shaping both the spatial and temporal aspects of calcineurin-mediated calcium signaling.
CnAbeta/NFAT (show NFATC1 Proteins) pathway modulates Nox.
Calcineurin regulates degradation of phosphodiesterase 3B, in addition to phosphodiesterase 4D (show PDE4D Proteins).
loss of beta isoform of calcineurin is sufficient to reproduce aspects of cyclosporine on diabetic renal hypertrophy but not matrix expansion; calcineurin beta appears to be a central mechanism involved in organ hypertrophy
Results indicate that myospryn functions as a novel inhibitor of the calcineurin signaling pathway in skeletal muscle.
Calcineurin Abeta1 shows a unique mode of action that improves cardiac function after myocardial infarction, activating different cardioprotective pathways without inducing maladaptive hypertrophy
A novel-splicing variant of calcineurin Ass (show ASS1 Proteins) CnAss-FK, which is encoded by an intron-retaining mRNA and is deficient in the autoinhibitory domain, is predominantly expressed in mature follicular keratinocytes.
The mRNA expressions of PPP3CB and MEF2C (show MEF2C Proteins) were significantly up-regulated, and CAMK1 (show CAMK1 Proteins) and PPP3R1 (show PPP3R1 Proteins) were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C (show MEF2C Proteins) and PLCE1 (show PLCE1 Proteins) compared to aortic valve disease patients
These findings therefore provide initial support for the novel mechanistic hypothesis that oxidation-induced global and/or local conformational changes within calcineurin
lower expression of PPP3CA and PPP3CB genes in atrium myocardium can be related to expressed postinfarction LV remodeling.
Present findings indicate that downregulation of hemoxygenase (show HMOX1 Proteins)-1 expression in neutrophils from hypertensive subjects is likely mediated by CN, which acts by hindering translocation to the nucleus of the transcription factor NRF2 (show GABPA Proteins).
The C allele of protein phosphatase 3 subunit alpha rs3804358 polymorphism was overrepresented in athletes compared with controls, whereas the T allele of protein phosphatase 3 subunit beta rs3763679 polymorphism was underrepresented in athletes.
ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function.
The expression of a constitutively active Calcineurin stimulates myoblast differentiation, whereas a Calcineurin antisense has the opposite effect.
two new complementary roles for calcineurin in the regulation of the early UPR (Unfolded Protein Responses)
[review] The nuclear localization sequence, a region spanning amino acids 172-183 of calcineurin A beta, is essential for recognition and shuttling of calcineurin into the nucleus by importin beta (show KPNB1 Proteins).
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
calcineurin A beta
, protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform
, serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
, CAM-PRP catalytic subunit
, PP2BA beta
, calmodulin-dependent calcineurin A subunit beta isoform
, calcineurin A2
, protein phosphatase 2B, catalytic subunit, beta isoform
, protein phosphatase from PCR fragment H32
, CaN Abeta
, Calcineurin subunit A beta
, protein phosphatase 3, catalytic subunit, beta isoform
, protein phosphatase-2Bb