Browse our anti-PPP3R1 (PPP3R1) Antibodies

Human Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) interaction partners

1. The CnB 5I/5D variation was found to be significantly associated with CAD. The 5-base pair deletion results in increased serum calcineurin levels.

2. The mRNA expressions of PPP3CB (show PPP3CB Antibodies) and MEF2C (show MEF2C Antibodies) were significantly up-regulated, and CAMK1 (show CAMK1 Antibodies) and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB (show PPP3CB Antibodies), MEF2C (show MEF2C Antibodies) and PLCE1 (show PLCE1 Antibodies) compared to aortic valve disease patients

3. we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4 (show TLR4 Antibodies)/MD2 (show LY96 Antibodies) complex together with the co-receptor CD14 (show NDUFA2 Antibodies)

4. CnB is a novel host-derived immunostimulatory factor, having a role as an agonist in monocytes, and specificity in TLR4 (show TLR4 Antibodies) signaling through TRAF3 (show TRAF3 Antibodies) and TRAF6 (show TRAF6 Antibodies), in response to various agonists.

5. Data (including data from micro-dissected trophoblasts and trophoblastic BeWo cell line) suggest that microRNA-512-3p participates in placental function by targeting PPP3R1, encoding a regulatory subunit of calcineurin B (show CAN Antibodies).

6. Further evidence that specific variations in MAPT (show MAPT Antibodies) (rs3785883) and PPP3R1 (rs1868402) are associated with accelerated progression of Alzheimer's disease

7. Expression level of PPP3R1 and GATA4 (show GATA4 Antibodies), and NFATC4 (show NFATC4 Antibodies) genes for transcription factors did not differ in studied subgroups of patients.

8. Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT (show NFATC1 Antibodies) targets required for replication, insulin (show INS Antibodies) storage, and secretion.

9. These findings reveal a novel signaling pathway (CnB-CD11b (show ITGAM Antibodies)-NF-kappaB (show NFKB1 Antibodies)-TRAIL) regulating TRAIL expression and may help to understand the roles of the calcineurin B subunit in the regulation of innate immunity.

10. CnB M118K fails to enhance the activities of NF-AT (show NFATC3 Antibodies) and p53 (show TP53 Antibodies) induced by CnA (show CAN Antibodies) in HeLa-s cells.

Mouse (Murine) Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) interaction partners

1. Calcineurin B1 deficiency in glial cells impairs the small intestine and leads to malnutrition and eventual death in mice, suggesting that calcineurin plays a novel and important role in enteric glial cells.

2. Expression of the RNA-binding protein, tristetraprolin (TTP (show ZFP36 Antibodies)) was down-regulated in response to calcineurin inhibition.

3. Mice lacking Calcineurin B (show CAN Antibodies) in CD11c (show ITGAX Antibodies)(high)MHCII(+) cells (Cnb1 (CD11c (show ITGAX Antibodies)) mice) spontaneously develop intestinal inflammation and are susceptible to induced colitis.

4. These results suggest that the PDZ domain (show INADL Antibodies) of PICK1 (show PICK1 Antibodies) directly interacts with calcineurin B (show CAN Antibodies) in osteoclast progenitor cells and promotes osteoclast differentiation through activation of calcineurin-NFAT (show NFATC1 Antibodies) signaling.

5. global deficiency of catalytic subunit Ppp3cb (show PPP3CB Antibodies), and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity

6. data demonstrate that decreasing calcineurin activity in the amygdala increases anxiety-like behaviors and to some extent depression-like behaviors.

7. Macrophage Wnt (show WNT2 Antibodies)-Calcineurin-Flt1 (show FLT1 Antibodies) signaling regulates mouse wound angiogenesis and repair.

8. Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT (show NFATC1 Antibodies) targets required for replication, insulin (show INS Antibodies) storage, and secretion.

9. intact calcineurin/NFAT (show NFATC1 Antibodies) signalling is critically required for p53 (show TP53 Antibodies) and senescence-associated mechanisms that protect against skin squamous cancer development

10. Mechanistically, loss of Heart-specific CnB1 reduced expression of key Ca(2 (show CA2 Antibodies)+)-handling genes that likely lead to arrhythmia and reduced contractility