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Rac2 signaling axis is critical in the regulation of macrophage differentiation and lung fibrosis in vivo.
distinct modes of Rac-regulated mast cell exocytosis: Rac2-mediated calcium influx and Rac1-mediated membrane ruffling.
Rac2 to modulates the level of Rac1-dependent macrophage IL-1beta (show IL1B Proteins) expression, which consequently determines extent of atherosclerotic calcification.
Rac1 and Rac2 have critical roles in skeletal metabolism.
Data indicate that cytosol-to-membrane translocation of the Nox regulatory subunit p47(phox) and the small GTPase (show RACGAP1 Proteins) Rac1/2 was increased in vessels from db/db (show LEPR Proteins) mice compared with db/+ mice, an effect blunted by atorvastatin.
Rac2 GTPase (show RACGAP1 Proteins) is activated downstream of alpha4beta1 integrin and the MCSF (show CSF1 Proteins) receptor to control tumor growth, metastasis and macrophage differentiation.
Rac2-deficient animals have higher rates of mortality in pulmonary fibrosis.
the levels of beta-catenin (show CTNNB1 Proteins) were reduced and not able to prevent the negative effect of Rac2 on PLD2 (show PLD2 Proteins) activity
Data show that the Phospholipase D2 (PLD2 (show PLD2 Proteins))-GTPase (show RACGAP1 Proteins) Rac2 protein-protein interaction is sufficient for the guanine nucleotide exchange factor (show ARHGEF12 Proteins) (GEF (show ARHGEF2 Proteins)) function.
Deletion of Rac1 and Rac2 in osteoclasts causes severe osteopetrosis (show CSF1 Proteins).
We found both the rs229527 allele within C1QTNF6 (odds ratio [OR] = 1.23, confidence interval [95% CI]: 1.12-1.33, pAllelic = 4.60 . 10-6) and the rs2284038 allele within RAC2 (OR = 1.10, 95% CI: 1.01-0.19, pAllelic = 3.00 . 10-2) showed significant associations with Graves' Disease susceptibility.
miR (show MLXIP Proteins)-24-1*/let-7a*-ARP2 (show ACTR2 Proteins)/3 complex-RAC (show AKT1 Proteins) isoforms pathway may represent a novel pathogenic mechanism for Hirschsprung disease.
P38 MAPK (show MAPK14 Proteins), phosphorylated P38 MAPK (show MAPK14 Proteins), and RAC2 regulated in mutual feedback and negative feedback regulatory pathways, resulting in the radioresistance of G0 cells.
R665W and L845F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 (show PLCG2 Proteins) Rerouting of the transmembrane signals emanating from BCR (show BCR Proteins) and converging on PLCgamma2 (show PLCG2 Proteins) through Rac (show AKT1 Proteins) in ibrutinib-resistant CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 (show PLCG2 Proteins) mutations or to prevent its development in ibrutinib-treated CLL patients.
Study showed that RhoA/Rac2 participate in hepatocellular tumorigenesis through their upregulation by AFAP1-AS1.
RAC1/RAC2 and SFK are proximal and essential for phosphatidylinositol 3-kinase (PI3K (show PIK3CA Proteins)) activation in NK cell-mediated direct cytotoxicity against Cryptococcus neoformans.
RAC2 specifically interacted with a set of mitochondrial proteins.
our present analysis reinforces the involvement in ACT of the regulatory NADPH oxidase (show NOX1 Proteins) subunit RAC2 gene variant rs13058338 and, to a lesser extent of the CYBA (show CYBA Proteins) gene variant rs4673.
homozygous loss-of-function RAC2 mutation in 2 patients with early-onset and progressive hypogammaglobulinemia(novel homozygous nonsense mutation in codon 56 (W56X)of RAC2 gene)
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.
Ras-related C3 botulinum toxin substrate 2
, EN-7 protein
, protein EN-7
, ras-related C3 botulinum toxin substrate 2
, Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2)
, small G protein
, RAS-related C3 botulinum substrate 2
, ras-related protein