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anti-Human Ret Proto-Oncogene Antibodies:
anti-Mouse (Murine) Ret Proto-Oncogene Antibodies:
anti-Rat (Rattus) Ret Proto-Oncogene Antibodies:
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Human Polyclonal Ret Proto-Oncogene Primary Antibody for WB - ABIN1882126
Siqueira, Romitti, da Rocha, Ceolin, Meotti, Estivalet, Puñales, Maia: The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma. in Endocrine-related cancer 2010
Show all 4 Pubmed References
Human Polyclonal Ret Proto-Oncogene Primary Antibody for ICC, IF - ABIN4350058
Luo, Tsuchiya, Il Park, Fausel, Kanngurn, Welcsh, Dzieciatkowski, Wang, Grady: RET is a potential tumor suppressor gene in colorectal cancer. in Oncogene 2013
Show all 2 Pubmed References
Human Monoclonal Ret Proto-Oncogene Primary Antibody for ELISA, WB - ABIN1724678
Young, Anderson, Anderson: Guidance cues involved in the development of the peripheral autonomic nervous system. in Autonomic neuroscience : basic & clinical 2004
Show all 2 Pubmed References
Human Monoclonal Ret Proto-Oncogene Primary Antibody for ELISA, WB - ABIN1724684
Myers, Mulligan: The RET receptor is linked to stress response pathways. in Cancer research 2004
Show all 2 Pubmed References
Human Monoclonal Ret Proto-Oncogene Primary Antibody for CyTOF, FACS - ABIN4900140
Fonseca-Pereira, Arroz-Madeira, Rodrigues-Campos, Barbosa, Domingues, Bento, Almeida, Ribeiro, Potocnik, Enomoto, Veiga-Fernandes: The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function. in Nature 2014
Show all 2 Pubmed References
Human Monoclonal Ret Proto-Oncogene Primary Antibody for IHC (p), IHC - ABIN269684
Barrenschee, Böttner, Hellwig, Harde, Egberts, Becker, Wedel: Site-specific gene expression and localization of growth factor ligand receptors RET, GFRα1 and GFRα2 in human adult colon. in Cell and tissue research 2013
Human Monoclonal Ret Proto-Oncogene Primary Antibody for FACS - ABIN4897243
Ibiza, García-Cassani, Ribeiro, Carvalho, Almeida, Marques, Misic, Bartow-McKenney, Larson, Pavan, Eberl, Grice, Veiga-Fernandes: Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence. in Nature 2016
Human Polyclonal Ret Proto-Oncogene Primary Antibody for WB - ABIN392039
de Martimprey, Bertrand, Fusco, Santoro, Couvreur, Vauthier, Malvy: siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma. in Nucleic acids research 2008
Human Polyclonal Ret Proto-Oncogene Primary Antibody for IHC (p), WB - ABIN392038
Takaki, Nakayama, Misawa, Nakagawa, Kuniyasu: In vitro formation of enteric neural network structure in a gut-like organ differentiated from mouse embryonic stem cells. in Stem cells (Dayton, Ohio) 2006
These data provide the first evidence for a physiologic role of these isoforms in RET pathway function.
Significantly, we show that introduction of mapk10 (show MAPK10 Antibodies) mutations into ret heterozygotes enhanced the ENS deficit, supporting MAPK10 (show MAPK10 Antibodies) as a Hirschsprung disease (HSCR (show EDNRB Antibodies)) susceptibility locus. Our studies demonstrate that ret heterozygous zebrafish is a sensitized model, with many significant advantages over existing murine models, to explore the pathophysiology and complex genetics of HSCR (show EDNRB Antibodies).
RET expression is investigated within the brain of zebrafish; both RET protein and mRNA are observed.
In animals lacking Ret or Gfra3 (show GFRA3 Antibodies) function, myogenic gene expression is reduced in forming opercular muscles, but not in non-opercular muscles derived from the same muscle anlagen.
evaluation of noncoding sequences at the zebrafish ret locus conserved among teleosts, and at the human RET locus, conserved among mammals
genes beyond RET may be implicated in the genesis of sporadic cases of HD
The frequencies of ALK, ROS1 (show ROS1 Antibodies) and RET rearrangements are low in non-adenocarcinoma NSCLC patients. And their clinical characteristics are similar to those in lung adenocarcinoma. Fusions of the above 3 genes are not prognostic factor for non-adnocarcinoma NSCLC patients.
BRAFV600E and RET/PTC and the expression of NF-kappaB (show NFKB1 Antibodies) promote the proliferation and migration of papillary thyroid carcinoma cells in vitro.
The RET proto-oncogene located on chromosome 10q11.2 encodes a 1114-amino acid transmembrane receptor with a cadherin-related motif and a cysteine-rich domain in the extracellular domain.
We found 6 single nucleotide polymorphisms in RET that were independent contributors to Hischsprung disease
data establish differences in the mechanisms of RET9 and RET51 ubiquitylation and internalization that may influence the strength and duration of RET isoform signals and cellular outputs.
Study demonstrate that the kinesin and kinase domains of KIF5B (show KIF5B Antibodies)-RET act together to establish an emergent microtubule and RAB (show HRB Antibodies)-vesicle-dependent RET-SRC (show SRC Antibodies)-EGFR (show EGFR Antibodies)-FGFR (show FGFR2 Antibodies) signaling hub. Study demonstrate that drugs designed to inhibit RET alone work poorly in KIF5B (show KIF5B Antibodies)-RET-transformed cells.
RET knockdown significantly decreased xenografts tumor growth in vivo, confirming the oncogenic impact of RET signaling in vivo.
Each of these autosomal dominant syndromes results from a specific germline mutation in unique genes: MEN1 is due to pathogenic MEN1 variants (11q13), MEN2A and MEN2B are due to pathogenic RET variants (10q11.21), MEN4 (show CDKN1B Antibodies) is due to pathogenic CDKN1B (show CDKN1B Antibodies) variants (12p13.1), and the HPT-JT syndrome is due to pathogenic CDC73 (show CDC73 Antibodies) variants (1q25).
RET p.C634F mutation is associated with Multiple Endocrine Neoplasia Type 2A with Cutaneous Lichen Amyloidosis.
These data support the inclusion of patients bearing RET alterations in ongoing and future molecularly enriched clinical trials to explore RXDX-105 efficacy across a variety of tumor types.
p75 (show NGFR Antibodies) is required for the development of the nonpeptidergic nociceptor lineage by fine-tuning Ret-mediated trophic support.
7-DHC efficiently supports Ret signaling in vitro.
Results showed that Mn-mediated age-related hearing loss involved a decreased expression and phosphorylation levels of c-Ret in spiral ganglion neurons.
Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRalpha1 (show GFRA1 Antibodies) or RET Impairs Normal Cerebellar Motor Learning
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
The cardiac GFRA2 (show GFRA2 Antibodies) signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase (show TYRO3 Antibodies).
Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.
Mechanistically, Ret is engaged in a positive feedback loop with Wnt/Wingless signalling, modulated by Src and Fak kinases.
Authors did not find evidence for genetic interaction between Ret and Sema3d (show SEMA3D Antibodies) affecting survival, presence of myenteric plexus or intestine transcriptome.
findings uncover a novel spinal circuit that mediates crosstalk between touch and pain pathways and suggest that some early RET positive Dorsal Horn neurons could function as pain "gating" neurons.
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
proto-oncogene tyrosine-protein kinase receptor Ret
, receptor tyrosine kinase
, ret proto-oncogene
, proto-oncogene tyrosine-protein kinase receptor Ret-like
, RET transforming sequence
, cadherin family member 12
, cadherin-related family member 16
, hydroxyaryl-protein kinase
, proto-oncogene c-Ret
, ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
, Ret gene for receptor tyrosin
, Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease)
, ret tyrosine kinase