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Human Monoclonal ROR1 Primary Antibody for IHC (fro), FACS - ABIN2689893
Broome, Rassenti, Wang, Meyer, Kipps: ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia. in Leukemia research 2011
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Human Polyclonal ROR1 Primary Antibody for CyTOF, FACS - ABIN4899817
Hudecek, Schmitt, Baskar, Lupo-Stanghellini, Nishida, Yamamoto, Bleakley, Turtle, Chang, Greisman, Wood, Maloney, Jensen, Rader, Riddell: The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor. in Blood 2010
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Human Monoclonal ROR1 Primary Antibody for WB - ABIN2476375
Zhang, Chen, Cui, Chuang, Yu, Wang-Rodriguez, Tang, Chen, Basak, Kipps: ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth. in PLoS ONE 2012
Human Monoclonal ROR1 Primary Antibody for ICC, ELISA - ABIN969385
Paganoni, Ferreira: Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2. in Journal of cell science 2005
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ROR1 and ROR2 (show ROR2 Antibodies) play distinct roles in endometrial cancer. ROR1 may promote tumor progression, while ROR2 (show ROR2 Antibodies) may act as a tumor suppressor in endometrioid endometrial cancer.
ROR1 is a promising immunotherapeutic target in many epithelial tumors; however, high cell surface ROR1 expression in multiple normal tissues raises concerns for on-target off-tumor toxicities. Clinical translation of ROR1-targeted therapies warrants careful monitoring of toxicities to normal organs and may require strategies to ensure patient safety
Report shows that ROR1 is highly expressed in colorectal cancer (CRC (show CALR Antibodies)) tissues when compared with their adjacent normal tissues. The Kaplan-Meier curve indicated that the CRC (show CALR Antibodies) patients with higher ROR1 expression had significantly shorter overall survival (OS), and those with lower ROR1 expression had longer OS.
this study reveals that 14-3-3zeta (show YWHAZ Antibodies) plays a critical role in Wnt5a (show WNT5A Antibodies)/ROR1 signaling, leading to enhanced CLL migration and proliferation.
these studies indicate HS1 (show EEF1A2 Antibodies) plays an important role in ROR1-dependent Wnt5a (show WNT5A Antibodies)-enhanced chemokine (show CCL1 Antibodies)-directed leukemia-cell migration.
This study demonstrates expression of ROR1 and its putative ligand Wnt5a (show WNT5A Antibodies) in Ewing sarcomas, and of an active ROR1 protein variant in cell lines. ROR1 silencing impaired cell migration in vitro.
expression of ROR1 may promote leukemia-cell activation and survival and enhance disease progression in patients with chronic lymphocytic leukemia.
the mechanistic regulation and linkage of the ROR1-HER3 (show ERBB3 Antibodies) and Hippo-YAP (show YAP1 Antibodies) pathway in a cancer-specific context
Data show that ROR1 contributes to melanoma progression by promoting cell growth and migration.
High ROR1-DNAJC6 (show DNAJC6 Antibodies) expression is associated with neoplasms.
Ror1 has a critical role in regulating SC proliferation during skeletal muscle regeneration
Ror1 is crucial for spiral ganglion neurons to innervate auditory hair cells. Impairment of ROR1 function largely affects development of the inner ear and hearing in humans and mice.
Although Ror1-mutant mice show no apparent defects in ureteric bud (UB) formation, Ror1; Ror2 (show ROR2 Antibodies)-double-mutant mice exhibit either defects in UB outgrowth and branching morphogenesis, associated with the loss of the MM from the UB domain, or ectopic formation of the UB.
Wnt5a (show WNT5A Antibodies)-Ror1 and Wnt5a (show WNT5A Antibodies)-Ror2 (show ROR2 Antibodies) signaling pathways regulated neurogenesis in the developing neocortex.
results identify resistin (show RETN Antibodies) as a potential inhibitory ligand for the receptor ROR1 and demonstrate, for the first time, that ROR1 plays an important role in adipogenesis and glucose homeostasis in 3T3-L1 cells
These findings suggest that Wnt5a (show WNT5A Antibodies)-Ror-Dishevelled (show DVL2 Antibodies) signaling constitutes a core noncanonical Wnt (show WNT2 Antibodies) pathway that is conserved through evolution and is crucial during embryonic development.
loss of the orphan receptor (show NR1D2 Antibodies) Ror1 results in a variety of phenotypic defects within the skeletal and urogenital systems
these data suggest that Ror1 and Ror2 (show ROR2 Antibodies) proteins play a key role in Wnt-5a (show WNT5A Antibodies)-activated signaling pathways leading to synapse formation in the mammalian CNS
Expression and subcellular localization of Ror tyrosine kinase (show TYRO3 Antibodies) receptors are developmentally regulated in cultured hippocampal neurons.
The ROR1 protein suppression using antisense oligonucleotides or RNA interference (RNAi), neurons extended shorter and less branched minor processes when compared to those in control cells.
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
neurotrophic tyrosine kinase, receptor-related 1
, tyrosine-protein kinase transmembrane receptor ROR1
, neurotrophic tyrosine kinase, receptor related 1
, tyrosine kinase orphan receptor 1
, receptor tyrosine kinase-like orphan receptor 1
, tyrosine-protein kinase transmembrane receptor ROR1-like
, inactive tyrosine-protein kinase transmembrane receptor ROR1