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Studied leucine rich repeat kinase 2 (LRRK2)-WAS protein family member 2 (WAVE2) pathway in modulation of phagocytosis in leukocytes, as well as its possible role for altered immune function in Parkinson's Disease.
The level of WASF2 in gastric cancer tissues was negatively correlated with miR (show MLXIP Proteins)-146a expression and had inverse clinicopathologic features. The newly identified miR (show MLXIP Proteins)-146a/WASF2 axis may provide a novel therapeutic target for gastric cancer.
These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 (show VPS72 Proteins) in U251 human glioma cells.
SH3BP1 (show SH3BP1 Proteins) promoted VEGF (show VEGFA Proteins) secretion via Rac1-WAVE2 signaling, so as to exert an augmentation on cell invasion and microvessel formation.
the MCP1 (show CCL2 Proteins)-induced cortactin (show CTTN Proteins) phosphorylation is dependent on PLCb3 (show PLCB3 Proteins)-mediated PKC (show PRRT2 Proteins) activation, and siRNA-mediated down-regulation of either of these molecules prevents cortactin (show CTTN Proteins) interaction with WAVE2
WASp and WAVE2 differ in their dynamics and their associated proteins
these results suggest that Arp2 (show ACTR2 Proteins)/3 and the upstream regulator, WAVE2, are essential co-factors hijacked by HIV for intracellular migration, and may serve as novel targets to prevent HIV transmission.
WAVE2 is down-regulated in gastric cancer
Cortactin (show CTTN Proteins) has a role as a scaffold for Arp2 (show ACTR2 Proteins)/3 and WAVE2 at the epithelial zonula adherens
data reveal a critical role for WAVE2 complex in regulation of cellular signaling and epithelial morphogenesis
Rho family GTPases use the I-BAR proteins, IRSp53 (show BAIAP2 Proteins) (also known as BAIAP2 (show BAIAP2 Proteins)), IRTKS (show BAIAP2L1 Proteins) and Pinkbar (show BAIAP2L2 Proteins), as a central mechanism to modulate cell morphology.
Data show that the primary effect of costimulation blockade was to decrease recruitment of the activator of actin nucleation WAVE2 (Wiskott-Aldrich syndrome protein family member protein 2) and cofilin (actin-severing protein) to F-actin.
The expression of NESH/Abi-3 (show ABI3 Proteins) caused degradation of endogenous Abi-1 (show ABI1 Proteins), which led to the formation of a NESH/Abi-3 (show ABI3 Proteins)-based WAVE2 complex.
This study demonstrated that WAVE2-Abi2 complex, which controls growth cone activity, is crucial for completing transition from a multipolar to bipolar shape.
Results of the present study show that the nucleation-promoting factors JMY (show JMY Proteins) and WAVE2 are critical for cytokinesis during development of mouse embryos.
These results identify Wasf2 as a novel target of intermittent PTH administration via the Wnt and phosphoinositide-dependent protein kinase signaling pathways.
The protein and messenger RNA levels of WAVE2 were decreased in aged oocytes, but the levels were normal in caffeine-treated aged oocytes.
mDia1 and WAVE2 are important Src (show SRC Proteins) homology 3 domain partners of IRSp53 (show BAIAP2 Proteins) in forming filopodia.
WAVE2 regulates oocyte polarization by regulating meiotic spindle, peripheral positioning, probably via an actin-mediated pathway, and is involved in polar body emission during mouse oocyte meiotic maturation.
sential role for Abi1 (show ABI1 Proteins) in embryonic survival and WAVE2 complex integrity
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene.
WAS protein family, member 2
, wiskott-Aldrich syndrome protein family member 2
, WASP family Verprolin-homologous protein 2
, WASP family protein member 2
, WASP family protein member 4
, protein WAVE-2
, putative Wiskott-Aldrich syndrome protein family member 4
, suppressor of cyclic-AMP receptor (WASP-family)
, verprolin homology domain-containing protein 2