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This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.
acid-sensing ion channel 2
, amiloride-sensitive cation channel 1, neuronal
, brain sodium channel 1
, mammalian degenerin homolog
, neuronal amiloride-sensitive cation channel 1
, amiloride-sensitive brain sodium channel
, amiloride-sensitive cation channel 1, neuronal (degenerin)
, amiloride-sensitive brain sodium channel 2
, acid-sensing (proton-gated) ion channel 2