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Study shows that ASIC2 promotes metastasis of colorectal cancer (CRC (show CALR Antibodies)) cells by activating the calcineurin/NFAT1 (show NFAT1 Antibodies) pathway under acidosis and high expression of ASIC2 predicts poor outcomes of patients with CRC (show CALR Antibodies).
The authors finally confirmed that the ASIC2b isoform is delivered to the cell surface from the endoplasmic reticulum by forming heteromers with ASIC2a isoform, and that the N-terminal region of ASIC2a is additionally required for the ASIC2a-dependent membrane targeting of ASIC2b.
The ASIC2 are involved in fear behaviours, learning and memory functions, and pain sensation.
The results show that acid-sensing ion channel 1 (show ACCN2 Antibodies), acid-sensing ion channel 2, and acid-sensing ion channel 3 (show ACCN3 Antibodies) are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel (show ACCN2 Antibodies)-like currents were elicited by extracellular acid stimuli.
results demonstrate the occurrence of ASIC2 and TrkB (show NTRK2 Antibodies) in the human intervertebral disc (IVD (show IVD Antibodies)), and the increased expression of both in pathological IVD (show IVD Antibodies) suggest their involvement in IVD (show IVD Antibodies) degeneration
distribution of ASIC2 in the human cutaneous mechanosensory system and suggest the involvement of ASIC2 in mechanosensation
This study suggests that ASIC2 may play a role as mediators of inflammatory pain and be involved in the pathogenesis of frozen shoulder.
Combinatorial analysis suggests a model of random mixing of ASIC1a (show ACCN2 Antibodies) and ASIC2a subunits to yield both 2:1 and 1:2 ASIC1a:ASIC2a heteromers together with ASIC1a (show ACCN2 Antibodies) and ASIC2a homomers.
The results showed that there was a significant increase in the mean relative optical density of ASIC2 and ASIC3 (show ACCN3 Antibodies) but not ASIC1a (show ACCN2 Antibodies) in the lining epithelium and glandular tubes of gastric mucosa in patients with Henoch-Schonlein purpura.
ACCN1 might be one of numerous susceptibility genes for panic disorder.
the potentiation of ASICs by quinine depends on the presence of the ASIC1a (show ACCN2 Antibodies), ASIC2a subunits, but not ASIC1b, ASIC3 (show ACCN3 Antibodies) subunits. Furthermore, we have determined the amino acids in ASIC1a (show ACCN2 Antibodies) that are involved in the modulation of ASICs by pHi.
ASIC2 deletion significantly protected the mouse brain from ischemic damage in vivo.
Studies with ASIC1a (show ACCN2 Antibodies)-ASIC2a chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys (show DNAJC5 Antibodies) residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels.
differential surface trafficking of ASIC1a (show ACCN2 Antibodies), ASIC2a, and ASIC2b, was investigated.
These data identify the LL motifs as a negative regulator of ASIC2a trafficking and function, and suggest novel regulatory mechanisms in acid signaling.
ASIC2 contributes to transduction of the renal myogenic response and has a protective role against renal injury and hypertension.
These results lend support to an emerging role of ASIC2 in the targeting of ASICs to surface membranes, and allows for interaction with PSD-95 (show DLG4 Antibodies) to regulate these processes.
A previously unknown postsynaptic current during neurotransmission mediated by ASIC1A (show ACCN2 Antibodies) and ASIC2 is well positioned to regulate synapse structure and function.
ASIC2 knockout mice showed less sensitization to challenge cocaine when compared to wild-type.
Currents from ASIC1a (show ACCN2 Antibodies)(-/-) muscle afferents were less pH-sensitive and displayed faster recovery, currents from ASIC2(-/-) showed diminished potentiation by zinc, and currents from ASIC3 (show ACCN3 Antibodies)(-/-) displayed slower desensitization than those from wild-type.
These results are the first demonstration that ASIC2 and ASIC4 (show ACCN4 Antibodies) are expressed in the adult zebrafish retina
The ASIC2 expression in this location might be related to detection of aquatic environment pH variations or to detection of water movement through the nasal cavity.
Muscles from horses submitted to strenuous exercises produce lactic acid, which may induce variable pain through ACCN differential properties; ACCN1 (show ACCN2 Antibodies) and ACCN3 (show ACCN3 Antibodies) genes have an ubiquitous expression but ACCN1 (show ACCN2 Antibodies) is more highly expressed in the spinal cord.
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.
acid-sensing ion channel 2
, amiloride-sensitive cation channel 1, neuronal
, brain sodium channel 1
, mammalian degenerin homolog
, neuronal amiloride-sensitive cation channel 1
, amiloride-sensitive brain sodium channel
, amiloride-sensitive cation channel 1, neuronal (degenerin)
, amiloride-sensitive brain sodium channel 2
, acid-sensing (proton-gated) ion channel 2