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results suggest that genetic variants at 9q22 are associated with the risk of both esophageal adenocarcinoma/Barrett esophagus and esophageal squamous cell carcinoma, possibly by regulating the function of BARX1
we provide supportive evidence that genetic variants at FOXP1, BARX1, and FOXF1 confer risk for the development of EAC.
expression of Barhl1 decelerates tumor growth both in human and in murine medulloblastomas.
PITX2, BARX1, and FOXC1 mutations were absent in De Hauwere syndrome and suggest that De Hauwere syndrome is caused by a different gene.
Regional expression of barx1 was observed in epithelium before mixed dentition, while during mixed dentition gene appeared in hyaline cartilage. Expression of barx1 appears in cleft lip palate affected structures mainly in mixed dentition.
barx1 represses joints and promotes cartilage in the craniofacial skeleton.
These results indicate an essential role for barx1 at early stages of chondrogenesis within the developing zebrafish viscerocranium.
data demonstrate the essential role of Barhl1 during hair cell development and provide a basis for the treatment of Barhl1 mutation-based deafness.
Given the important role of Barhl1 in brain development, it was proposed that perturbations of thyroid hormone -mediated transcriptional control of Barhl1 may play a role in the impaired neurodevelopment induced by hypothyroidism.
These results suggest that Barhl1 plays an essential role in the migration and survival of cerebellar granule cells and precerebellar neurons and functionally link Barhl1 to the NT-3 signaling pathway during cerebellar development
Barhl1 on the other hand was found to act as a transcriptional repressor with repressive activity not restricted to a particular domain of Barhl1.
Result suggest that Barhl1 is exclusively transcribed in restricted CNS domains at differential transcription levels which suggest a highly regulated transcriptional mechanism.
Barhl1 is crucially required for the survival but not for the specification of zonal layer neurons in the superior colliculus
High-level, cell-specific Bargl1expression in the inner ear & CNS depends on both its 5' promoter & 3' enhancer sequences. 2 homeoprotein binding motifs can be occupied & activated by Barhl1.
Math1 directly regulates the Mbh genes in CGCs. Furthermore, a dominant-negative form of the Mbh proteins disrupted proper
Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter.
, bar-class homeodomain protein MBH2
, barH-like 1 homeobox protein
, barH-related homeobox protein 1
, BarH-like homeobox 1
, homeobox protein BarH-like 1
, barH-class homeodomain transcription factor 4
, bar class homeoprotein Barx1b
, homeobox protein BarH-like 1b