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Results confirm that CEACAM6 promoted cell proliferation mediated by cyclin D1 (show CCND1 Proteins)/CDK4 (show CDK4 Proteins).
Data indicate that a heterozygous missense mutation, c.505G>A (p.G169R) in exon 3 of the CEACAM16 gene (carcinoembryonic antigen-related cell adhesion molecule 16) was identified in autosomal dominant nonsyndromic hearing loss family.
CEACAM16 can probably form higher order structures with other tectorial membrane proteins such as alpha-tectorin and beta-tectorin (show TECTB Proteins) and influences the physical properties of the tectorial membrane
data identify CEACAM16 as an alpha-tectorin-interacting protein that concentrates at the point of attachment of the TM to the stereocilia and, when mutated, results in ADNSHL at the DFNA4 locus
The data of this study indicated that CEACAM16 is required for striated (show NSDHL Proteins)-sheet matrix formation. Its continual expression may stabilize the noncollagenous TM matrix.
The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss.
carcinoembryonic antigen-related cell adhesion molecule 16
, carcinoembryonic antigen like-2 protein
, chromosome 1 GSS clone AHTH152
, CEA-related cell adhesion molecule 16
, B-cell leukemia/lymphoma 3