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GLUT1 ectopic overexpression makes PCa (show FLVCR1 Proteins) cells more resistant to glucose deprivation and oxidative stress-induced (show SQSTM1 Proteins) cell death. Under glucose deprivation, GLUT1 overexpressing PCa (show FLVCR1 Proteins) cells sustains mitochondrial SOD2 (show SOD2 Proteins) activity, compromised after glucose removal, and significantly increases reduced glutathione (GSH)
Results confirm the positive expression of Glut1 in colorectal neoplasm (CRC (show CALR Proteins)) and its involvement in proliferation and cell survival of cancer cells. Its silencing inhibits the proliferation and promoted apoptosis of CRC (show CALR Proteins) cells by inactivating TGF-beta (show TGFB1 Proteins)/PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) signaling pathway.
p-ERK (show EPHB2 Proteins)-mediated phosphorylation and stabilization of JMJD2B during glucose deprivation contributes to its role in glucose uptake and cell viability, which may be modulated through epigenetically upregulation of GLUT1 in colon cancer cells.
work characterized the clustering distribution of GLUT1 and linked its spatial structural organization to the functions, which would provide insights into the activation mechanism of the transporter.
This study present the results from the molecular genetics study of the SLC2A1 gene in Bulgarian patients with different forms of genetic generalized epilepsy having emerged in childhood.
Expression of SLC5A5 mRNA was negatively correlated with SLC2A1 mRNA. This finding provides a molecular basis for the management of PTC (show F9 Proteins) with negative WBS (show CDKN1C Proteins) using F-FDG (show SMUG1 Proteins) PET scans. In addition, higher expression of SLC5A5 mRNA was associated with less PTC (show F9 Proteins) [papillary thyroid cancer] recurrence, but not with deaths.
GLUT-1 in nasopharyngeal carcinoma and its clinical significance
PPAR-gamma (show PPARG Proteins) and Akt (show AKT1 Proteins) regulate GLUT1 and GLUT3 (show SLC2A3 Proteins) surface localization during Mycobacterium tuberculosis infection.
YAP1 (show YAP1 Proteins) interacted with TEAD1 (show TEAD1 Proteins), exerted their transcriptional control of the functional target, glucose transporter 1 (Glut1).
experiments mainly reveal that the CREB1 (show CREB1 Proteins) could affect glucose transport in glioma cells by regulating the expression of GLUT1, which controlled the metabolism of glioma and affected the progression of glioma.
Immunoreactivity of vGluT1 in continuous theta-burst stimulation (iTBS; cTBS (show CTBS Proteins)) repeated session (RS) decreased, while GLT-1 (show SLC1A2 Proteins) increased in cTBS (show CTBS Proteins) SS and cTBS (show CTBS Proteins) RS, compared to control
Expression of GLUT1 is stimulated by hyperglycemia and low oxygen supply, and this overexpression was associated with increased activity of GLUT1 in the cell membrane that contributes to the impairment of the RPE (show RPE Proteins) secretory function of PEDF (show SERPINF1 Proteins).
GLUT1 may play an important role in Prostate Cancer progression via mediating glycolysis and proliferation. There is potential crosstalk between GLUT1-mediated glycolysis and androgen sensitivity in Prostate Cancer.
ARAP2 knockdown did not affect fatty acid uptake but reduced basal glucose uptake, total levels of the glucose transporter GLUT1, and GLUT1 levels in the plasma membrane and the lipid micro-domain fraction.
TBC1D5 (show TBC1D5 Proteins) shuttling to autophagosomes during metabolic stress facilitates retromer-dependent GLUT1 trafficking.
inhibition of GLUT1 activity and/or expression is shown to impair TGF-beta (show TGFB1 Proteins)-driven fibrogenic processes, including cell proliferation and production of profibrotic mediators
B cell leukemia-induced inhibition of T cell Akt (show AKT1 Proteins)/mTORC1 signaling and glucose metabolism drives T cell dysfunction; metabolic defects included reduced Akt (show AKT1 Proteins)/mammalian target of rapamycin (show FRAP1 Proteins) complex 1 (mTORC1) signaling, decreased expression of the glucose transporter Glut1 and hexokinase 2 (show HK2 Proteins), and reduced glucose uptake
This study demonstrates a strict requirement for GLUT1 in the early stages of mammary tumorigenesis in vitro and in vivo.
GLUT1-dependent glycolysis regulates fibrogenesis in aged lung.
Data (including data from studies using transgenic mice) suggest that Glut1 (glucose transporter type 1) is a critical downstream target of Hif1a (hypoxia-inducible factor 1 (show HIF1A Proteins), alpha subunit (show POLG Proteins)) mediating hyperglycemia-induced extracellular matrix accumulation in kidney via regulation of Nox4 (show NOX4 Proteins) (NADPH oxidase (show NOX1 Proteins) type 4) expression in nephropathy due to diabetes type 1.
pGlcT, together with MEX1, contributes significantly to the export of starch degradation products from chloroplasts in A. thaliana leaves and and that this starch-mediated pathway for photoassimilate export via pGlcT and MEX1 is essential for the growth and development of A. thaliana. [pGlcT]
Low GLUT1 and GLUT3 (show SLC2A3 Proteins) expression in nonclassical monocytes was unaltered during differentiation into macrophages. GLUT4 (show SLC2A4 Proteins) mRNA was only detectable in unstimulated macrophages. Neither monocytes nor macrophages were insulin (show INS Proteins) responsive.
the different conformations of the GLUT-1 transporter in luminal (blood facing) and abluminal (brain facing) membranes of bovine cerebral endothelial cells arise from differential phosphorylation of GLUT-1
Significant increases in GLUT1 gene expression were observed during early lactation.
Hyperthermia-induced Hsp90 (show HSP90 Proteins).eNOS (show NOS3 Proteins) preserves mitochondrial respiration in hyperglycemic endothelial cells by down-regulating Glut-1 and up-regulating G6PD (show G6PD Proteins) activity.
distinct domains of the glucose transporter GLUT1 mediate HTLV envelope binding and virus entry
Expression of GLUT1 was evaluated in LLC-PK1 cells grown on porous membranes for the development of an artificial kidney.
results suggest that glucose is transported to the axonal cleft intracytoplasmically and delivered to the cleft by GLUT1 transporters
This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia.
, glucose transporter type 1, erythrocyte/brain
, hepG2 glucose transporter
, human T-cell leukemia virus (I and II) receptor
, solute carrier family 2, facilitated glucose transporter member 1
, solute carrier family 2, member 1
, Solute carrier family 2 a 1 (facilitated glucose transporter) brain
, Solute carrier family 2, facilitated glucose transporter member 1
, solute carrier family 2 (facilitated glucose transporter), member 1
, solute carrier family 2 member 1
, glucose transporter protein
, glucose transporter type 1
, solute carrier family 2 (facilitated glucose transporter), member 1 L homeolog
, glucose transport protein