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anti-Human EPAS1 Antibodies:
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Fish Polyclonal EPAS1 Primary Antibody for ChIP, ELISA - ABIN151051
Conrad, Freeman, Beitner-Johnson, Millhorn: EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. in The Journal of biological chemistry 1999
Show all 500 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody for ChIP, ELISA - ABIN151063
Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. in The American journal of pathology 2007
Show all 149 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody for ELISA, IHC - ABIN250056
Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. in Biology of reproduction 2004
Show all 19 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody for ELISA, ICC - ABIN250055
Mekhail, Gunaratnam, Bonicalzi, Lee: HIF activation by pH-dependent nucleolar sequestration of VHL. in Nature cell biology 2004
Show all 15 Pubmed References
Fish Polyclonal EPAS1 Primary Antibody for ELISA, ICC - ABIN249868
Alvarez-Tejado, Naranjo-Suarez, Jiménez, Carrera, Landázuri, del Peso: Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. in The Journal of biological chemistry 2001
Show all 17 Pubmed References
Human Monoclonal EPAS1 Primary Antibody for IHC (fro), IHC (p) - ABIN1742588
Wiesener, Turley, Allen, Willam, Eckardt, Talks, Wood, Gatter, Harris, Pugh, Ratcliffe, Maxwell: Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. in Blood 1998
Show all 4 Pubmed References
Human Polyclonal EPAS1 Primary Antibody for IF (p), IHC (p) - ABIN686662
Li, Chen, Shao, Tang, Chen, Chen, Xu: Oxidative stress induces the decline of brain EPO expression in aging rats. in Experimental gerontology 2016
Human Monoclonal EPAS1 Primary Antibody for AA, ELISA - ABIN863099
Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. in The Journal of clinical investigation 2009
Show all 4 Pubmed References
Human Monoclonal EPAS1 Primary Antibody for IHC (p) - ABIN2473999
Pike, Phadwal, Simon, Harris: ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia. in Molecular biology reports 2012
Hamster Monoclonal EPAS1 Primary Antibody for ELISA, FACS - ABIN406865
Su, Li, Cui, Ji, Geng, Chai, Ma, Bai, Yang, Wuren, Ge, Rondina: The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness. in High altitude medicine & biology 2015
The present study demonstrates that hypoxia-induced downregulation of Dicer (show DICER1 Antibodies) serves as key mechanism in the maintenance of the hypoxic response in HCC (show FAM126A Antibodies) and that prevention of hypoxic suppression of Dicer (show DICER1 Antibodies) not only alleviates hypoxia-induced upregulation of HIF1alpha (show HIF1A Antibodies) and HIF2alpha and other key hypoxia-responsive/HIF target genes, but also inhibits hypoxia-induced metastatic phenotypes such as EMT (show ITK Antibodies) and increased cell motility.
HIF-2alpha dictates the resistance of human pancreatic cancer cells to TRAIL under normoxic and hypoxic conditions and transcriptionally regulates survivin (show BIRC5 Antibodies) expression.
SOD3 (show SOD3 Antibodies) reduced HIF prolyl hydroxylase domain protein activity, which increased hypoxia-inducible factor-2alpha (HIF-2alpha) stability and enhanced its binding to a specific vascular endothelial cadherin (show CDH5 Antibodies) promoter region.
Functionally active PHD2 (show EGLN1 Antibodies) SNP rs516651 , located in the key pathway for the hypoxic-inflammatory response, is associated with increased 30-day mortality in Acute Respiratory Distress Syndrome (ARDS) patients. In contrast, the PHD2 (show EGLN1 Antibodies) SNP rs480902 is not. Furthermore, the HIF-2alpha SNP [ch2 (show Acyp1 Antibodies): 46441523(hg18)] GG-genotype was neither present in our ARDS patients of Caucasian heritage nor in healthy Caucasian blood donors.
We genotyped 347 Tibetan individuals from varying altitudes for both the Tibetan-specific EGLN1 haplotype and 10 candidate SNPs in the EPAS1 haplotype and correlated their association with hemoglobin levels.
HIF-2alpha plays an important role in regulating the expression of c-Myc (show MYC Antibodies) in chronic hypoxia, and consequently controls the sensitivity of colon cancer cells to 5-FU treatment in this environment.
The present study identifies novel HIF-2alpha-target genes that may regulate endothelial sprouting during prolonged hypoxia.
Exogenous acetate augments Acss2 (show ACSS2 Antibodies)/HIF-2 dependent cancer growth and metastasis in cell culture and mouse models
the structural model of the HIF2a-pVHL (show VHL Antibodies) complex presented in this study enhances understanding of how HIF2a is captured by pVHL (show VHL Antibodies). Moreover, the important contact amino acids that we identified may be useful in the development of drugs to treat HIF2a-related diseases.
Thus, we provide evidence here that HIF-2a is a critical regulator of PD-L1 (show CD274 Antibodies) at both mRNA and protein levels and that HIF-2a regulates the expression of PD-L1 (show CD274 Antibodies) by binding directly to the HRE-4 in the PD-L1 (show CD274 Antibodies) proximal promoter.
HIF-1alpha (show HIF1A Antibodies)-dependent, HIF-2alpha-independent angiogenesis and constitutive diuresis is caused by Vhl (show VHL Antibodies) deletion in renal epithelia
A novel biological pathway has been discovered of soluble biglycan (show BGN Antibodies) inducing HIF-2alpha protein stabilization and Epo (show EPO Antibodies) production presumably in an oxygen-independent manner, ultimately giving rise to secondary polycythemia.
Data suggest that chronic hypoxia enhances HIF-2alpha stability, which causes increased arginase expression and dysregulates normal vascular NO homeostasis.
Data show that Tet1 (show TET1 Antibodies) modulates HIF-2alpha and HIF-1alpha (show HIF1A Antibodies) through different mechanisms.
intestine HIF-2alpha regulates ceramide metabolism mainly from the salvage pathway, by positively regulating the expression of Neu3 (show Neu3 Antibodies), the gene encoding neuraminidase 3 (show Neu3 Antibodies). These results suggest that intestinal HIF-2alpha could be a viable target for hepatic steatosis therapy
endothelial EPAS1 has a global protective role during glomerular hypertensive injuries without influencing the hypertensive effect of angiotensin II
findings indicate that HIF-2alpha increases cancer cell growth by up-regulating YAP1 (show YAP1 Antibodies) activity
Chronic activity of HIF2 in stromal progenitors impairs kidney development. Finally, these data confirm the concept that normal stroma function is essential for normal tubular differentiation.
this study shows that HIF-2alpha acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha and susceptibility to infection
in neurons HIF-1 (show HIF1A Antibodies) and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a (show HIF1A Antibodies)/Hif2a-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke
immunostaining for HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a