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These results show for the first time that IQGAP1 is up-regulated in Laryngeal squamous cell carcinoma (LSCC)tissues and plays an important role in LSCC cell proliferation and invasiveness, which indicates that IQGAP1 could work as an oncogene (show RAB1A Proteins) and may serve as a promising molecular target for treatment of LSCC.
High IQGAP1 expression is associated with invasion in endometrial cancer.
Examined the expression of IQGAP1 in different pancreatic cancer cell lines and we found that IQGAP1 level is highly correlated with the degree of malignancy of pancreatic cancer cell metastasis. The proliferation, metastasis, motility and tumorigenesis in SW1990 human pancreatic cells were greatly impaired by down-regulating IQGAP1 expression with RNA interference.
Findings discover the IQGAP1 SUMOylation is a novel regulatory mechanism to enhance tumorigenesis and development of CRC (show CALR Proteins) in vitro and in vivo.
IQGAP1 may have a role in podocyte gene regulation in glomerular disease.
When HEK293T cells were co-transfected with IQGAP1 and VCP (show vcp Proteins), an immunoprecipitation assay revealed that binding of IQGAP1 with disease-related mutant (R155H or A232E) VCP (show vcp Proteins) was markedly reduced compared to wild-type VCP (show vcp Proteins). This suggests that reduction of IQGAP1 and VCP (show vcp Proteins) interaction may be associated with the pathophysiology of inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD (show vcp Proteins)).
the results show that IQGAP1 is a novel regulator of type I IFN production, possibly via interacting with NLRC3 in human monocytic and epithelial cells
The structural basis for Cdc42 (show CDC42 Proteins)-induced dimerization of IQGAP1 and IQGAP2 (show IQGAP2 Proteins) has been uncovered.
The LGR5 primarily functions via the IQGAP1-Rac1 pathway to strengthen cell-cell adhesion in normal adult crypt stem cells and colon cancer cells.
findings suggest a novel role of IQGAP1 in insulin (show INS Proteins)-regulated interaction between caveolae and cytoskeletal elements of the adipocyte, and that this is quelled in the diabetic state
Alterations in IQGAP1 signalling promote the emergence of cancer stem cells and gastric adenocarcinoma development in the context of an H. pylori infection.
propose that the GRD and CT domains regulate IQGAP1 localization to retracting actin networks to promote a tumorigenic role in melanoma cells
Data highlight a unique mechanism of formin (show FMN1 Proteins) action in which mDia1 and INF2 (show INF2 Proteins) function in series to stabilize MTs (show NEU2 Proteins) and point to IQGAP1 as a scaffold that facilitates the activation of one formin (show FMN1 Proteins) by another.
Hectd1 (show HECTD1 Proteins) regulates the protein level of IQGAP1 through ubiquitination.
Loss of IQGAP1 results in impaired insulin (show INS Proteins) signaling and glucose homeostasis in vivo.
These data reveal that IQGAP1 binds to YAP (show YAP1 Proteins) and modulates its co-transcriptional function, suggesting that IQGAP1 participates in Hippo signaling.
IQGAP1 has a strong signaling relationship with Ras genes in induction of cancer and it is considered as a key gene for induction or suppression of the hepatocellular carcinoma.
IQGAP1 has the potential to modulate airway contraction severity in acute asthma.
we propose that IQGAP1 acts as a small GTPase (show RACGAP1 Proteins) scaffolding platform within the small GTPase (show RACGAP1 Proteins) network, and recruits and/or regulates small GTPases, small GTPase (show RACGAP1 Proteins) regulators and effectors to orchestrate cell behavior
This finding has new implications for involvement of IQGAP1 in cell polarization and migration events and potentially in cell cycle-associated nuclear envelope assembly/disassembly.
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
RasGAP-like with IQ motifs
, ras GTPase-activating-like protein IQGAP1
, Cdc42-Rac1 effector protein