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Neuropilin-1 (show NRP1 Proteins) and its co-receptor plexinA1 are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process.
Data suggest that Fyn (show FYN Proteins) tyrosine kinase (show TXK Proteins) (Fyn (show FYN Proteins))-dependent phosphorylation at two critical tyrosines is a key feature of vertebrate plexin A1 (PlxnA1) and plexin A2 (PlxnA2 (show Plxna2 Proteins)) signal transduction.
We thus screened 250 patients for the presence of mutations in PLXNA1, and identified different nonsynonymous mutations (p.V349L, p.V437L, p.R528W, p.H684Y, p.G720E, p.R740H, p.R813H, p.R840Q, p.A854T, p.R897H, p.L1464V, p.K1618T, p.C1744F), all at heterozygous state, in 15 patients.
Semaphorin-3a (show SEMA3A Proteins), neuropilin-1 (show NRP1 Proteins) and plexin-A1 are axonal guidance molecules that have been recently implicated in regulating bone metabolism.
a novel mutation in the PLXNA1 receptor (c.2587G>A) in newly established pancreatic cell line, is reported.
Data indicate that plexin A1-4 (PLXNA1-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
neuropilin 1 (show NRP1 Proteins) and plexin A1 transmembrane domains interaction
Expression of Plexin A1 in gastric carcinoma was significantly higher than that in normal gastric mucosa.
Breast carcinoma cells support an autocrine pathway involving SEMA3A (show SEMA3A Proteins), plexin-A1, and NP1 (show NPX1 Proteins) that impedes their ability to chemotax.
PlexinA1 may play an important role in the occurrence and development of gastric carcinoma, and be related to tumor angiogenesis and proliferation.
In malignant pleural mesothelioma cells, plexin-A1 and VEGF-receptor 2 (VEGF (show VEGFA Proteins)-R2) are associated in a complex which are involved in survival pathways.
PLXNA1 mediates the acquisition of malignant phenotypes induced by autocrine SEMA3A (show SEMA3A Proteins) signaling in lung cancer cells.
Study showed that progenitor cells lining the telencephalic ventricles express PlexinA1 and that absence of this receptor impairs neurogenesis in the developing forebrain
PlexinA1 mediates both Semaphorin and Slit signaling
genetic findings demonstrate that Sema3a (show SEMA3A Proteins) repellent signaling plays a role in the establishment of proper afferent projections in SAG (show RNF7 Proteins) neurons, and this signaling likely occurs through a receptor complex involving Npn1 (show NRP1 Proteins) and either plexinA1 or plexinA3 (show PLXNA3 Proteins)
A novel direct interaction between the Sema3a (show SEMA3A Proteins) signaling receptor plexinA1 and nephrin (show NPHS1 Proteins), linking extracellular Sema3a (show SEMA3A Proteins) signals to the slit-diaphragm signaling complex, was identified.
Data demonstrate an essential direct function of Sema3A (show SEMA3A Proteins)-Nrp1 (show NRP1 Proteins)-PlexinA1 signaling in lymphatic valve formation.
These findings suggest a mechanism by which a complex of Sema6D (show SEMA6D Proteins), Nr-CAM (show NRCAM Proteins), and Plexin-A1 at the chiasm midline alters the sign of Sema6D (show SEMA6D Proteins) and signals Nr-CAM (show NRCAM Proteins)/Plexin-A1 receptors on retinal ganglion cells to implement the contralateral retinal cell projection.
Results suggest that plexin-A1 and B1 interact in the adult brain and transduce semaphorin 3A (show SEMA3A Proteins) signaling in cooperation.
Plexin-A1 affects t-cell-dendritic cell interaction but not antigen processing or binding.
Plexin-A1 forms a receptor complex with vascular endothelial growth factor receptor type 2 in heart morphogenesis
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm.
, plexin A1a
, plexin 1
, semaphorin receptor NOV
, plex 1