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anti-Human EOMES Antibodies:
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Human Polyclonal EOMES Primary Antibody for WB - ABIN1881298
Wang, Ge, Xue, Li: [Role of transcription factor T-bet and Eomes in IFN-gamma secretion of different human T cell subsets]. in Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2010
Show all 3 Pubmed References
Mouse (Murine) Monoclonal EOMES Primary Antibody for FACS - ABIN4898948
La, Mäkelä, Chan, Rossello, Nefzger, Legrand, De Seram, Polo, Hobbs: Identification of dynamic undifferentiated cell states within the male germline. in Nature communications 2018
Show all 2 Pubmed References
Human Monoclonal EOMES Primary Antibody for CyTOF, FACS - ABIN4900372
Latos, Sienerth, Murray, Senner, Muto, Ikawa, Oxley, Burge, Cox, Hemberger: Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. in Genes & development 2015
Show all 2 Pubmed References
Human Monoclonal EOMES Primary Antibody for FACS - ABIN4897601
Lunemann, Martrus, Goebels, Kautz, Langeneckert, Salzberger, Koch, J Bunders, Nashan, van Gisbergen, Altfeld: Hobit expression by a subset of human liver-resident CD56brightNatural Killer cells. in Scientific reports 2017
Human Polyclonal EOMES Primary Antibody for CyTOF, FACS - ABIN4900371
Raab, Klingenstein, Möller, Illing, Tosic, Breunig, Kuales, Linta, Seufferlein, Arnold, Kleger, Liebau: Reprogramming to pluripotency does not require transition through a primitive streak-like state. in Scientific reports 2017
Human Polyclonal EOMES Primary Antibody for IHC, IHC (p) - ABIN4308348
Mosenson, Zloza, Nieland, Garrett-Mayer, Eby, Huelsmann, Kumar, Denman, Lacek, Kohlhapp, Alamiri, Hughes, Bines, Kaufman, Overbeck, Mehrotra, Hernandez, Nishimura, Guevara-Patino, Le Poole: Mutant HSP70 reverses autoimmune depigmentation in vitiligo. in Science translational medicine 2013
Eomesodermin (EOMES) was increased in T cells from healthy donors homozygous for the PTPN22 risk allele and correlated with a decreased number of naive CD4(+) T cells. An accumulation of EOMES(+) CD4(+) T cells was observed in synovial fluid of RA patients.
The authors propose that NK cells are defined by coexpression of T-bet and Eomes, while ILC1s express only one of these factors, either T-bet or Eomes, depending on the tissue or the species.
This study enhances the knowledge that the variant of EOMES is associated with increasing risk in Chinese RRMS patients and provides a potential therapeutic target in RRMS.
our exploratory study suggests that EOMES, BCL6 and GZMB gene expression are aberrant within the PB T cell transcriptome of HT patients. The association of this transcription signature with the heterogeneity of HT and disease control is suggested.
EOMES specifically activates a cardiogenic program in human embryonic stem cells.
Studies suggest there are two nonoverlapping NK cell populations that are potentially liver resident in humans: CD49a+ NK cells and Eomes hi.
Reciprocal regulation of BMF and BIRC5 is linked to Eomes overexpression in colorectal cancer.
Eomes(hi) NK cells can be recruited from the circulation during adult life and that circulating Eomes(lo) NK cells are able to upregulate Eomes and molecules mediating liver retention under cytokine conditions similar to those in the liver.
EOMES expression was low in multiple sclerosis (MS), and stable over time. The low EOMES/TBX21 phenotype in MS reflects cd56+ cell dysregulation.
we identified a higher Eomes mRNA expression as an independent good prognostic factor for OS and PFS in mRCC patients treated with sorafenib.
Eomes(+) CD4(+) T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis.
the level of T-bet and Eomesodermin, two T-box transcription factors regulating lymphocyte effector functions, is strongly reduced in NK cells from allogeneic hematopoietic stem cell transplantation recipients compared with healthy control subjects.
This study showed that EOMES (rs2724509; flanking) associated with Alzheimer disease.
This study supports the concept that poor human viral-specific CD8(+) T cell functionality is due to an inverse expression balance between T-bet and Eomes
Report a global loss of 5hmC identified three new genes (ECM1, ATF5, and EOMES) with potential anti-cancer functions that may promote the understanding of the molecular mechanisms of hepatocellular carcinoma development and progression.
HHEX promotes hepatic specification by repressing EOMES expression.
CD127 is downregulated at a transcriptional level in memory CD8 T cells in association with upregulation of Eomes expression in HIV infected patients.
The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease.
these results provide the evidence that transcription factors CDX2 and EOMES may play critical roles in human induced trophoblast progenitor cell generation.
a novel pathway by which TIP60 and ThPOK synergistically suppresses Eomes function and IFNgamma production, which could contribute to the regulation of inflammation.
Smad2 and Eomesodermin a (Eomesa) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa forms a general component of the Smad2 signalling complex in zebrafish.
Eomesa has a strictly maternal role in the initiation of epiboly, and is required for normal expression of the endoderm markers sox32, bon and og9x; however it is not essential for endoderm formation.
Eomes is a Nodal-transducing factor that acts, directly and indirectly, in concert with FoxH1 to carry out all Nodal-dependent processes during early mesendoderm specification.
Eomes plays a role in specifying the embryonic organizer.
regulates the expression of a zygotic homeobox transcription factor mtx2
Results suggest that eomesodermin promotes endoderm induction in marginal blastomeres by facilitating the assembly of a transcriptional activating complex on the casanova promoter.
These results suggest that both Eomes genes are involved in the zebrafish immune response, particularly in lymphocyte function as has been found in mammals.
as conceptuses attach to the uterine epithelium, IFNT gene transcription is down-regulated by an increase in EOMES expression and EOMES-CREBBP binding in the attached trophoblast cells.
IL-12 promoted increasing T-bet and down regulating Eomes to promote the CD8+ T cell differentiation to memory T-cells in invasive pulmonary aspergillosis mouse model.
These data indicate that TBR2 contributes to suppressing RA signaling in INPs, thereby enabling them to re-enter the cell cycle and delay neuronal differentiation.
These data identify TBR2 as a major determinant of the INP-specific traits by regulating both genetic and epigenetic pathways.
Tbr2 regulates the tempo of laminar fate implementation for all cortical layers.
results revealed Eomes expression is restricted to distinct tissues and Vgamma subsets; gammadelta T cells expressing Eomes presented a CD44+-activated memory phenotype with increased expression of Ly6C and Il2rb and showed higher IFN-gamma production upon stimulation; Eomes expression could be induced in peripheral and thymic gammadelta T cells by IL-12 and in particular by IL-4
activation of the Eomes target genes Foxa2 and Lhx1 is associated with higher order chromatin reorganization.
this study shows that TGF-beta promotes salivary gland innate lymphoid cells differentiation by suppressing Eomes
The Foxo3-Eomes pathway is central to achieve the complete specialized gene program required for pathogenic Th1 cell differentiation.
HDAC11-knockout T cells displayed enhanced proliferation, proinflammatory cytokine production, and effector molecule expression of Eomes and TBX21 transcription factors previously shown to regulate inflammatory cytokine and effector molecule production.
increases the number of ALP-positive colonies after iPSC induction and decreases expression levels of Eomes and p21 mRNAs. Based on these observations, we propose that the CCR4-NOT deadenylase activity contributes to iPSC induction.
Results indicated that Eomes bound to the Ifng promoter and multiple conserved noncoding sequences in stimulation-dependent and stimulation-independent manners.
Demonstrate by using the T-box brain-2(Cre) mouse line that progenitor cells derived cells contribute 67.5% of glutamatergic but not GABAergic or astrocytic cells to all cortical layers including the earliest generated subplate zone.
a critical role for IRF4 in regulating protective anti-viral CD8+ T cell responses by ensuring a balanced ratio of T-bet to Eomes
Eomes expression is a key determinant of conventional NK versus Type 1 helper Innate Lymphoid Cell maturation following lineage specification.
T-cell-specific deletion of the Eomes gene remarkably ameliorates the late-onset experimental autoimmune encephalomyelitis.
find that while stimulation of CD27 in isolation drives weak Eomesodermin(hi) T-bet(lo) CD8(+) T-cell responses to OVA immunization
The data identify a novel role for Eomes in CD4+ T cells and indicate that Eomes expression may act by limiting Foxp3 induction, which may contribute to the association of EOMES to susceptibility to multiple sclerosis.
type I interferon signalling in CD8(+) T cells drives Eomes expression.
TGF-beta/tbr2 receptor signaling pathway may be required for prevention of beta cell death after initial cell proliferation following pancreatectomy.
the expression of T-bet, Eomes and GATA-3 in combination with additional differentiation molecules within CD4+ and CD8beta+ T cell subsets from different organs of healthy pigs.
This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation.
T-box brain protein 2
, eomesodermin homolog
, eomesodermin homolog (Xenopus laevis)