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Co-expressed yeast MED21 and MED7 in E. coli to determine structure.
Blocking MED1/MED21 expression caused hyperproliferation of keratinocytes
This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants.
mediator complex subunit 21
, SRB7 suppressor of RNA polymerase B homolog
, hypothetical protein
, RNA polymerase II holoenzyme component SRB7
, RNAPII complex component SRB7
, mediator of RNA polymerase II transcription subunit 21
, SRB7 (supressor of RNA polymerase B) homolog