Browse our Mediator Complex Subunit 28 Proteins (MED28)

Full name:: Mediator Complex Subunit 28 Proteins (MED28)

On www.antibodies-online.com are 8 Mediator Complex Subunit 28 (MED28) Proteins from 3 different suppliers available. Additionally we are shipping Mediator Complex Subunit 28 Antibodies (35) and Mediator Complex Subunit 28 Kits (12) and many more products for this protein. A total of 60 Mediator Complex Subunit 28 products are currently listed.

Synonyms:: 1500003D12Rik, AI451633, AU045690, Eg1, FKSG20, magicin, RGD1305875, wu:fc74b11, zgc:103633

list all proteins	Gene Name	GeneID	UniProt
	MED28	80306	Q9H204
	MED28	305391	P68943
	MED28	66999	Q920D3
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Human Mediator Complex Subunit 28 (MED28) interaction partners

MED28 modulates the development of epithelial-mesenchymal transition through NFkappaB in human breast cancer cells.
All trans-retinoic acid can reverse the suppressive effect of MED28 on HBP1 and E-cadherin and inactivate the Wnt/beta-catenin pathway in colorectal cancer, suggesting a protective effect of ATRA against colorectal cancer.
This paper describes a link between Med23 and IFN-lambda3, provides evidence for the crucial role of IFN-lambda in HSV-1 immune control.
These data indicate that MED28 regulates cellular migration in a MEK1-dependent manner in human breast cancer cells, reinforcing the important cellular roles of MED28.
High MED28 is associated with breast cancer.
demonstrate an interaction between Grb2 and magicin. In addition, merlin is capable of forming a ternary complex with magicin and Grb2
EG-1 is a positive stimulator of cellular proliferation, and may possibly be involved in signaling pathways involving Src and MAPK activation.
May serve as a multi-faceted adaptor/scaffold to relay cellular signaling to the cytoskeleton and from the cytoskeleton to the nucleus.
EG-1 may be involved in signaling pathways including c-Src activation.
EG-1 has a role in breast tumor growth
Study reports that down-regulation of human Med28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell (SMC)differentiation; conversely, overexpression of MED28 represses SMC gene expression.

Mediator Complex Subunit 28 (MED28) Protein Profile

Protein Summary

May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Alternative names and synonyms associated with Mediator Complex Subunit 28 (MED28)

mediator complex subunit 28 (MED28)
mediator complex subunit 28 (Med28)
mediator complex subunit 28 (med28)

1500003D12Rik protein
AI451633 protein
AU045690 protein
Eg1 protein
FKSG20 protein
magicin protein
RGD1305875 protein
wu:fc74b11 protein
zgc:103633 protein

Protein level used designations for MED28

mediator of RNA polymerase II transcription, subunit 28 homolog , mediator complex subunit 28 , endothelial-derived gene 1 , endothelial-derived protein 1 , mediator of RNA polymerase II transcription subunit 28 , merlin and Grb2-interacting cytoskeletal protein , tumor angiogenesis marker EG-1 , endothelial-derived , mediator of RNA polymerase II transcription, subunit 28

GENE ID	SPECIES
425350	Gallus gallus
461133	Pan troglodytes
488813	Canis lupus familiaris
80306	Homo sapiens
305391	Rattus norvegicus
513972	Bos taurus
493610	Danio rerio
101121011	Ovis aries
66999	Mus musculus

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