Browse our MSI1 Proteins (MSI1)

Full name:: Musashi Homolog 1 (Drosophila) Proteins (MSI1)

On www.antibodies-online.com are 5 Musashi Homolog 1 (Drosophila) (MSI1) Proteins from 4 different suppliers available. Additionally we are shipping MSI1 Antibodies (140) and MSI1 Kits (3) and many more products for this protein. A total of 152 MSI1 products are currently listed.

Synonyms:: anon-EST:Liang-2.35, CG5099, clone 2.35, Dmel\\CG5099, DMSIDNA, Dsim\\GD21224, dsim_GLEANR_4982, GD21224, m-Msi-1, msi, msi1h, Musahi1, musashi, Musashi-1, Musashi1, nrp-1B, SIDNA, XNrp-1

list all proteins	Gene Name	GeneID	UniProt
	MSI1	4440	O43347
	MSI1	17690	Q61474
	MSI1	259272	Q8K3P4
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MSI1 Proteins (MSI1) by Origin

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Relevant Pathways for MSI1 Proteins

Stem Cell Maintenance

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Fruit Fly (Drosophila melanogaster) Musashi Homolog 1 (Drosophila) (MSI1) interaction partners

show specific evidence for a cell-autonomous requirement for Msi family proteins in regulating stem cell differentiation, leading to the identification of an RNA-binding protein required for spermatogonial stem cell maintenance

Human Musashi Homolog 1 (Drosophila) (MSI1) interaction partners

findings indicate that MSI1 plays a leading role in stress granule formation that grants cancer stem cell properties and chemoresistant stress granules in GBM, in response to stressful conditions via the PKR (show PKLR Proteins)/eIF2alpha (show EIF2A Proteins) signalling cascade.
Enhanced expression of Musashi-1 was observed in adenomyosis foci in comparison with endometrial cells. The most intensive staining was found in nodular adenomyosis, especially in epithelial cells during the secretion phase. These data attest to the role of somatic stem cells in the development and progression of various forms of adenomyosis.
Msi1 acts as a stemness-associated gene in esophageal cancer cell lines and could serve as a prognostic marker in patients with ESCC.
MSI1 and MSI2 (show MSI2 Proteins) bind and regulate the mRNA stability and translation of proteins operating in essential oncogenic signaling pathways..This review provides a current overview of Musashi as a cancer driver and novel therapeutic target.
Musashi-1 has a role in regulating AKT (show AKT1 Proteins)-derived IL-6 (show IL6 Proteins) autocrinal/paracrinal malignancy and chemoresistance in glioblastoma
MSI1 was a target of miR (show MLXIP Proteins)-181a-5p, a microRNA involved in the regulation of cancer development. The expression levels of MSI1 and miR (show MLXIP Proteins)-181a-5p were negatively correlated in NSCLC.
Musashi-1 interacts with the Zika genome and enables viral replication.
Msi1promoted epithelial-mesenchymal transformation of cervical neoplasms via activation of the Wnt (show WNT2 Proteins) signaling pathway and contributing to poor prognosis.
our results suggest a role for MSI1 in double-strand break repair and that its inhibition may enhance the effect of radiotherapy
Results show that Meis1 (show MEIS1 Proteins) may have a positive feedback with Msi1 during the esophageal squamous cell carcinoma progression.

Mouse (Murine) Musashi Homolog 1 (Drosophila) (MSI1) interaction partners

Msi1 has two RNA-binding domains.
leptin's direct stimulatory actions on gonadotrope GnRHR (show GNRHR Proteins) correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. There also is a direct MSI1 interaction with 3'-UTR of Gnrhr (show GNRHR Proteins) mRNA.
Msi (show EBP Proteins) proteins are dispensable for normal homeostasis and self-renewal of the active intestinal stem cell.
photoreceptors lack prototypical neuronal splicing factors and their splicing profile is driven to a significant degree by the Musashi 1 (MSI1) protein. A striking feature of the photoreceptor splicing program are exons that display a "switch-like" pattern of high inclusion levels in photoreceptors and near complete exclusion outside of the retina.
Given that deregulated fatty acid metabolism plays a key role in kidney fibrosis, these results demonstrate a novel connection between fatty acid and Msi1, an RNA-binding protein, in kidney fibrosis
A Mouse Model of Targeted Musashi1 Expression in Whole Intestinal Epithelium Suggests Regulatory Roles in Cell Cycle and Stemness.
studies highlight Msi (show EBP Proteins) reporters as a unique tool to identify therapy resistance, and define Msi (show EBP Proteins) signalling as a central regulator of pancreatic cancer
the RNA-binding protein Musashi 1 competes with miR130a and -206 for interaction with tachykinin mRNA
MSI1 and MSI2 (show MSI2 Proteins) display distinct expression profiles during mammalian folliculogenesis and that MSI2 (show MSI2 Proteins) is required for pre-antral follicle development
Osteoarticular expression of Msi1 protein is increased in joints with CIA (show NCOA5 Proteins)-induced lesion and absent in nonlesioned joints, suggesting that this protein is expressed when the lesion is produced in order to favor tissue repair.

Xenopus laevis Musashi Homolog 1 (Drosophila) (MSI1) interaction partners

Genome-wide analysis of CPEB1- and Msi1-associated mRNAs identified 491 common targets, thus revealing a new layer of cytoplasmic polyadenylation elements-mediated translational control.
specific association of Musashi with the noncanonical poly(A) polymerase (show PAPOLA Proteins) germ line development defective-2 (GLD2 (show PAPD4 Proteins))
Xenopus Musashi proteins regulate translation of the Musashi1 mRNA during oocyte maturation.
Ringo/cyclin-dependent kinase (show CDK1 Proteins) and mitogen-activated protein kinase (show MAPK1 Proteins) signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes.
These findings indicate that Musashi function is necessary to establish the temporal order of maternal mRNA translation during Xenopus meiotic cell cycle progression.
Msi-1 expression is upregulated in the adult progenitor cells and plays important roles in their maintenance and/or active proliferation during amphibian gastrointestinal remodeling.
Visual deprivation for 2 days increased proliferation of musashi1-immunoreactive radial glial progenitors

MSI1 Protein Profile

Protein Summary

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.

Alternative names and synonyms associated with MSI1

musashi (msi)
musashi RNA binding protein 1 (msi1)
GD21224 gene product from transcript GD21224-RD (Dsim\msi)
musashi RNA binding protein 1 (MSI1)
musashi RNA-binding protein 1 (Msi1)
musashi RNA binding protein 1 S homeolog (msi1.S)

anon-EST:Liang-2.35 protein
CG5099 protein
clone 2.35 protein
Dmel\\CG5099 protein
DMSIDNA protein
Dsim\\GD21224 protein
dsim_GLEANR_4982 protein
GD21224 protein
m-Msi-1 protein
msi protein
msi1h protein
Musahi1 protein
musashi protein
Musashi-1 protein
Musashi1 protein
nrp-1B protein
SIDNA protein
XNrp-1 protein

Protein level used designations for MSI1

, , , , , , , , , , , , , , , , , , , , , , , , , , , CG5099-PA CG5099-PB CG5099-PC CG5099-PD CG5099-PE CG5099-PF CG5099-PH msi-PA msi-PB msi-PC msi-PD msi-PE msi-PF msi-PH mushashi musashi homolog 1 Musashi 1 Dsim\\GD21224-PA Dsim\\msi-PA GD21224-PA msi musashi 1 RNA-binding protein Musashi homolog 1 RNA-binding protein Musashi-1 musashi-1 musashi1 Musashi homolog 1(Drosophila) nrp-1B

GENE ID	SPECIES
43087	Drosophila melanogaster
496961	Xenopus (Silurana) tropicalis
6729631	Drosophila simulans
100352797	Oryctolagus cuniculus
527436	Bos taurus
4440	Homo sapiens
17690	Mus musculus
259272	Rattus norvegicus
399271	Xenopus laevis

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