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Prox1 is a critical transcription factor for the differentiation of myoblasts via bi-directional crosstalk with Notch1 (show NOTCH1 Proteins).
PROX1 is a new prognostic biomarker for 1p19q non-codeleted high-grade astrocytomas that have progressed from pre-existing low-grade tumors and harbor IDH mutations.
ERbeta in both normal and cancerous colon epithelial cells upregulates miRNA-205, which subsequently reduces PROX1 through direct interaction with its 3'UTR
The aim of this study was to examine the association between HHEX (show HHEX Proteins) (rs5015480) and PROX1 (rs340874) gene polymorphisms and Gestational diabetes mellitus (GDM) .Despite these associations, PROX1 gene variants were not previously examined in women with GDM; however, our results suggest a lack of such an association.
PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.
study achieved a long-lasting expression of Prox1 in lymphatic endothelial-like cells, and it provided a potentially useful approach for developing novel therapies for limb lymphedema and lymphatic system-related diseases
In gastric cancer, high cytoplasmic PROX1 expression is an independent marker of better prognosis.
High PROX1 and beta-catenin (show CTNNB1 Proteins) expression were independent factors for better prognosis in pancreatic ductal adenocarcinoma.
Data suggest that DBC1 has a dual function in regulating beta-catenin (show CTNNB1 Proteins)-PROX1 signaling axis: as a coactivator for both beta-catenin (show CTNNB1 Proteins) and PROX1.
PROX1 gene is a strong candidate of early onset of diabetes with variations depending on ethnicity.
Prox1 (show C16orf35 Proteins) is a critical transcription factor for the differentiation of myoblasts via bi-directional crosstalk with Notch1 (show NOTCH1 Proteins).
the embryonic dermal blood capillary plexus constitutes a local source of embryonic lymphatic endothelial cells that contributes to the formation of the dermal lymphatic vascular network. Rare PROX1 (show C16orf35 Proteins)-positive endothelial cells exit the capillary plexus in a Ccbe1 (show CCBE1 Proteins)-dependent manner to establish discrete embryonic lymphatic endothelial cell clusters.
PROX1 (show C16orf35 Proteins) controls expression of genes regulating lipid homeostasis.HDAC3 interacts with PROX1 (show C16orf35 Proteins).
the neurogenic and oligodendrogliogenic lineages in the two adult neurogenic niches exhibit a distinct requirement for Prox1 (show C16orf35 Proteins).
Our study demonstrates that Prox1 (show C16orf35 Proteins)-GFP/Flk1 (show KDR Proteins)::myr-mCherry mice are a useful model for studying coordinated hemangiogenic and lymphangiogenic responses
Prox1 (show C16orf35 Proteins) was first expressed in all developing neurons, followed by a decrease in type II primary auditory neurons as they matured.
Data indicate that prospero-related homeobox 1 (Prox1) has a role in regulating energy homeostasis in hepatocytes.
These results are the first demonstration that Prox1 (show C16orf35 Proteins) activity protects pancreatic cells from acute tissue damage and early neoplastic transformation. Additional data in our study indicate that this novel role of Prox1 (show C16orf35 Proteins) involves suppression of pathways associated with inflammatory responses and cell invasiveness.
the data show that Prox1 (show C16orf35 Proteins) regulates proliferation and differentiation of the oligodendrocyte cell lineage, and is a relevant component of the endogenous regenerative response to Central nervous system injury.
using a transgenic reporter line, we show that prox1a is initially expressed in different endothelial compartments, becoming restricted to lymphatic endothelial cells only at later stages
Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.
Prox1 functions as a tissue-specific coregulator of Ff1b
Our findings indicate that prox1 activity is crucial for the proper development of the otp1 (show OTOP1 Proteins)-positive hypothalamic neuronal precursors to their terminal CA phenotype
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants.
prospero homeobox 1
, prospero homeobox protein 1-like
, Prox 1
, prospero-related homeobox 1
, homeobox prospero-like protein PROX1
, prospero homeobox protein 1
, prospero-related homeobox gene 1