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Human Monoclonal SAV1 Primary Antibody for IF, IP - ABIN566210
Mardin, Lange, Baxter, Hardy, Scholz, Fry, Schiebel: Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. in Nature cell biology 2010
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Human Polyclonal SAV1 Primary Antibody for ELISA - ABIN451700
Yoo, Soung, Lee, Park, Kim, Nam, Han, Kim, Lee, Lee: Mutational analysis of salvador gene in human carcinomas. in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
, 45 kDa WW domain protein
, WW domain-containing
, protein salvador homolog 1
, WW domain-containing protein 3
, WW domain-containing protein 4
, Salvador homolog 1 protein