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Human SMAD1 Protein expressed in Wheat germ - ABIN1320591
Andrews, Schneider, Yang, Michaels, Chen, Tang, Emkey: Identification of substrates of SMURF1 ubiquitin ligase activity utilizing protein microarrays. in Assay and drug development technologies 2010
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Data show that interplay of Smad1/5 and MAP kinase (show MAPK1 Proteins) signaling system (ERK (show MAPK1 Proteins) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.
this study uncovers that smad1 and smad9 (show SMAD9 Proteins) act redundantly to each other downstream of smad5 (show SMAD5 Proteins) to mediate ventral specification and to regulate embryonic myelopoiesis.
that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5 (show SMAD5 Proteins).
This report provides a genetic analysis of primary nociceptive neuron mechanisms that promote sensitization in response to injury. Drosophila melanogaster larvae whose primary nociceptive neurons were reduced in levels of specific components of the BMP signaling pathway, were injured and then tested for nocifensive responses to a normally subnoxious stimulus.
LTR sequence of the MDG4 retrotransposon contains the MAD protein (show MXD1 Proteins) binding site that affects the east-dependent repression
we identify key roles for the Zelda and Zerknullt transcription factors in establishing the resulting expression domain, and find widespread binding of insulator proteins to the Mad and Brinker-bound genomic regions. Analysis of embryos lacking the BEAF-32 insulator protein shows reduced transcription of a peak BMP target gene and a reduction in the number of amnioserosa cells, the fate specified by peak BMP signaling.
Mad linker phosphorylations control the intensity and range of the BMP-activity gradient in developing Drosophila tissues.
During development, synaptic pMad accumulation followed the arrival and clustering of ionotropic glutamate (show GRIN2A Proteins) receptors at neuromuscular junction synapses.
The actions of Brat at synapses are mediated through mothers against decapentaplegic (Mad), the signal transduction effector of the bone morphogenetic protein (BMP) signaling pathway.
Mad has distinct signal transduction roles in the BMP (show TGFb Proteins) and Wnt (show WNT4 Proteins) pathways depending on its phosphorylation state.
Yorkie (show YAP1 Proteins) and Mad physically bind each other, and 410 bp minimal enhancer of bantam that responds to Yorkie:Mad in vivo and in cultured cells, was identified.
Heterodimers of SAX and TKV play an important role in extending the BMP activity gradient by facilitating DPP diffusion and assisting GBB signaling through functional complexes with type II receptors.
importin-beta11 function interacts with the bone morphogenic protein (show TGFb Proteins) pathway to regulate a pool of phosphorylated mothers against decapentaplegic that must be present at the presynapse for its proper development and function
Data show that miR (show MLXIP Proteins)-26b-5p suppresses Twist1 (show TWIST1 Proteins)-induced EMT (show ITK Proteins), invasion, and metastasis of HCC (show FAM126A Proteins) cells by targeting SMAD1 (show GARS Proteins).
Testosterone promoted tube formation of human umbilical endothelial cells, which was blocked by c-Src (show SRC Proteins) and ERK1/2 inhibitors or by the knockdown of Smad1 (show GARS Proteins).
Low doses of IL1B (show IL1B Proteins) activate the BMP/Smad signaling pathway to promote the osteogenesis of periodontal ligament stem cells, but higher doses of IL1B (show IL1B Proteins) inhibit BMP/Smad signaling through the activation of NF-kappaB (show NFKB1 Proteins) and MAPK (show MAPK1 Proteins) signaling, inhibiting osteogenesis.
Store operated calcium entry negatively regulates the Smad1 (show GARS Proteins) signaling pathway and inhibits Col (show HDAC1 Proteins) IV protein production in glomerular mesangial cells.
A significant association was found between the low expression of inhibitory protein SMAD-7 (show SMAD7 Proteins) and both zeta-chain-associated protein kinase (show CDK7 Proteins) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2 (show SMAD2 Proteins)/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (show GARS Proteins)/8 and lower SMAD-4 (show SMAD4 Proteins) expression in chronic lymphocytic leukemia cells
melatonin treatment was found to downregulate TNFalpha (show TNF Proteins)-induced SMURF1 (show SMURF1 Proteins) expression and then decrease SMURF1 (show SMURF1 Proteins)-mediated ubiquitination and degradation of SMAD1 (show GARS Proteins) protein
The expression of specific targets Smad1 (show GARS Proteins) and Osterix (show SP7 Proteins) was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (show MUC7 Proteins)+). As miR (show MLXIP Proteins)-30b, miR (show MLXIP Proteins)-133a, and miR (show MLXIP Proteins)-143 are negatively regulated by Pi and restored by Mg(2 (show MUC7 Proteins)+) with a congruent modulation of their known targets Runx2 (show RUNX2 Proteins), Smad1 (show GARS Proteins), and Osterix (show SP7 Proteins), our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
the BMP-2 (show BMP2 Proteins)/Smad1 (show GARS Proteins)/5/RUNX2 (show RUNX2 Proteins) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (show BGLAP Proteins) synth
Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a is mediated by the increased expression of its target gene, SMAD1 (show GARS Proteins).
The expression SMAD1 (show GARS Proteins) protein showed a significant correlation with lung cancer differentiation and lymphatic metastasis (P < 0.05), but not with genders, ages, tumor sizes and histological types of lung cancer patients (P>0.05).
AA-enhanced cardiomyogenesis thus relies on the ability of AA to modulate the ratio of SMAD signaling among the TGFbeta (show TGFB1 Proteins)-superfamily receptor signaling pathways
Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2 (show RUNX2 Proteins)) expression through S1PR2 (show S1PR2 Proteins)/RhoA (show RHOA Proteins)/ROCK/Smad1/5/8 signaling.
these results identify the PI3K-GSK3-SMAD1 axis as a central node integrating multiple signaling networks that govern bone formation and homeostasis.
We discovered that Smad1/5/4-Amhr2 (show AMHR2 Proteins)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1/5/4-Amhr2 (show AMHR2 Proteins)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.
these studies characterize an accessory TGF-beta (show TGFB1 Proteins)-stimulated BMP R-Smad signaling mechanism in interstitial cells of the developing lung.
these results identify a novel function of YAP (show YAP1 Proteins) in neocortical astrocytic differentiation and proliferation, and reveal a BMP2 (show BMP2 Proteins)-YAP (show YAP1 Proteins)-SMAD1 pathway underlying astrocytic differentiation in the developing mouse neocortex.
Dynamin (show DNM1 Proteins)-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2 (show BMP2 Proteins)) and its receptors is dispensable for the initiation of Smad signaling
Thyroid-specific Smad1 and Smad5 (show SMAD5 Proteins) double-knockout (Smad1/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.
Smad1 and Smad5 (show SMAD5 Proteins) have overlapping functions to govern hepcidin (show HAMP Proteins) transcription. Moreover, erythropoietin (show EPO Proteins) and erythroferrone target Smad1/5 signaling and require Smad1/5 to suppress hepcidin (show HAMP Proteins) expression.
Actin cytoskeleton depolymerization inhibites BMP2 (show BMP2 Proteins) signaling via blocking of Smad by dephosphorylated CNN1 (show CNN1 Proteins) in osteoblast cells under simulated microgravity.
interactions between miR (show MYLIP Proteins)-26 and the Smad1 3'UTR modulate Smad1 function in the establishment of axial patterning.
a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
MAD homolog 1
, SMAD, mothers against DPP homolog 1
, mothers against decapentaplegic homolog 1
, mothers against decapentaplegic-like protein 1
, MAD (mothers against decapentaplegic, Drosophila) homolog 1
, SMA- and MAD-related protein 1
, SMAD 1
, SMAD family member 1
, mothers against DPP homolog 1
, mother against decapentaplegic
, mothers against decapentaplegi
, mothers against decapentaplegic
, mothers against dpp
, phosphorylated smad
, MAD, mothers against decapentaplegic homolog 1
, Mad-related protein 1
, TGF-beta signaling protein 1
, transforming growth factor-beta signaling protein 1
, transforming growth factor-beta-signaling protein 1
, Smad 1
, mad-related protein 1
, mothers-against-DPP-related 1
, MAD homolog1 (mothers against decapentaplegic, Drosophila)
, mothers against DPP
, BMP pathway effector
, BMP signal transducer Smad1
, Sma- and Mad-related protein 1