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anti-Human TET1 Antibodies:
anti-Mouse (Murine) TET1 Antibodies:
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Human Polyclonal TET1 Primary Antibody for ChIPSeq, ChIP - ABIN2668522
Feng, Wang, Li, Zeng, Kuang, Li, Yue: TET1-mediated different transcriptional regulation in prostate cancer. in International journal of clinical and experimental medicine 2015
Show all 2 Pubmed References
Mouse (Murine) Monoclonal TET1 Primary Antibody for ICC, IF - ABIN5563987
Bauer, Göbel, Nagaraj, Colantuoni, Wang, Müller, Kremmer, Rottach, Leonhardt: Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT). in The Journal of biological chemistry 2015
Show all 2 Pubmed References
Human Polyclonal TET1 Primary Antibody for ICC, IF - ABIN4358581
Zhao, Zhang, Xia, Zhou, Cao: Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells. in Oncology letters 2015
The expression of TET1, TET2 (show TET2 Antibodies), and TET3 (show TET3 Antibodies) was lower in the villi in early pregnancy loss group than in normal pregnancy group
Our study demonstrates the existence of a TET1/DUOX2 (show DUOX2 Antibodies)/ROS (show ROS1 Antibodies)/EMT (show ITK Antibodies) axis that could play a role in colon cancer chemo-resistance and the aggressiveness of this cancer.
this study illustrates the involvement of TET1 in the different arms of the DNA damage response (DDR (show DDR1 Antibodies)) and suggests its loss results in the continued survival of cells with genomic instability
Data show that knockdown of STAT (show STAT1 Antibodies) transcription factors STAT3 (show STAT3 Antibodies) and/or STAT5 (show STAT5A Antibodies) reduces DNA methylcytosine dioxygenase Ten-eleven translocation 1 (TET1) level.
data demonstrated that miR4284 could promote tumor cell growth, migration and invasion by directly targeting TET1 in gastric cancer, which may provide a potential therapeutic target for gastric cancer treatment.
Low TET1 expression is associated with colorectal cancer.
Infrequent occurrence of TET1, TET3 (show TET3 Antibodies), and ASXL2 (show ASXL2 Antibodies) mutations in myelodysplastic/myeloproliferative neoplasms.
the findings of this study indicate that miR27a3p is upregulated, while TET1 is downregulated in human osteosarcoma cells
TET1 gene expression might serve as a reliable predictor for patients survival in acute myeloid leukemia (show BCL11A Antibodies).
Study provides evidence that low-expression of TET1 in oral squamous cell carcinoma (OSCC) stem cells may stimulate MGMT (show MGMT Antibodies) promoter methylation, while inhibiting MGMT (show MGMT Antibodies) mRNA expression, which ultimately strengthens the sensitivity of OSCC stem cells in regards to chemotherapeutics.
DNMT3A (show DNMT3A Antibodies) and TET1 regulate the epigenome and gene expression at specific targets via their functional interplay.
Tet1 overexpression affected adult neurogenesis with oligodendrocyte differentiation in the hippocampal dentate gyrus of Tet1-TG mice. In addition, Tet1 overexpression induced the elevated expression of immediate early (show JUN Antibodies) genes, such as Egr1 (show EGR1 Antibodies), c-fos, Arc (show NOL3 Antibodies), and Bdnf (show BDNF Antibodies), followed by the activation of intracellular calcium signals in prefrontal and hippocampal neurons.
The down-regulation of TET1 relieves its repression of the methylated Lhb (show LHB Antibodies) gene promoter, which is then hydroxymethylated and activated by TET2 (show TET2 Antibodies) for full reproductive competence.
Tet1 deficiency is associated with hypermethylation of a subset of ICRs in germ cells.
e results showed mTet1 modified mGSCs had better self-renewal and proliferation ability than wild-type mGSCs, mTet1 could also up-regulate JMJD3 (show Kdm6b Antibodies) to decrease H3K27me3, which also showed to suppress the MEK (show MDK Antibodies)-ERK (show EPHB2 Antibodies) pathway. Furthermore, Co-IP analysis demonstrated that TET1 interact with PCNA (show PCNA Antibodies) and HDAC1 (show HDAC1 Antibodies) by forming protein complexes to comprehensively regulate dairy goat mGSCs and spermatogenesis.
Tet1/2/3 proteins have a key role in modulating Wnt (show WNT2 Antibodies) signaling and establishing the proper balance between neural and mesodermal cell fate determination in mouse embryos and embryonic stem cells
TET1 and TET2 (show TET2 Antibodies) play an important role in the proliferation of neural stem cells in the adult mouse brain.
findings reveal a novel role for TET1, an enzyme important for DNA hydroxymethylation, in the brain's reward circuitry in modulating stress responses in mice. Also identify a subset of genes that are regulated by TET1 in this circuitry.
These findings suggest that the catalytic and scaffolding activities of TDG (show TDG Antibodies) are essential for retinoic acid-dependent gene expression and provide important insights into the mechanisms underlying targeting of TET-TDG (show TDG Antibodies) complexes.
these results indicate that miR (show MLXIP Antibodies)-29 is a direct regulator of Tet1 in mouse ESCs (show NR2E3 Antibodies)
TET3 (show TET3 Antibodies) dioxygenase was present in the very first embryo stages, in contrast to TET1 and AICDA (show AICDA Antibodies).
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.
CXXC finger 6
, CXXC zinc finger 6
, CXXC-type zinc finger protein 6
, leukemia-associated protein with a CXXC domain
, methylcytosine dioxygenase TET1
, ten-eleven translocation 1 gene protein
, ten-eleven translocation-1
, tet oncogene 1
, ten-eleven translocation 1 gene protein homolog
, tet methylcytosine dioxygenase 1