Browse our anti-VANGL2 (VANGL2) Antibodies

Mouse (Murine) Vang-Like 2 (Van Gogh, Drosophila) (VANGL2) interaction partners

1. The Vangl2 phosphorylation, which was previously identified to be induced by Wnt5a (show WNT5A Antibodies) signaling, is required for Vangl2 functions in mammalian Planar cell polarity (PCP (show BMP1 Antibodies)) in multiple tissues.

2. type II spiral ganglion neurons make a distinctive 90 degrees turn towards the cochlear base to synapse with 10-15 outer hair cells. this axon turning event requires planar cell polarity signaling and is disrupted in Vangl2 and Celsr1 (show CELSR1 Antibodies) knockout mice and VANGL2 acts non-autonomously from the cochlea to direct turning.

3. In Pax2 (show PAX2 Antibodies)-Cre; V1V2 Conditional knockout mice, the loss of both VANGL proteins significantly disrupts planar polarity throughout the utricular maculae

4. The Celsr3 (show CELSR3 Antibodies)-mediated signaling pathway responds to the inhibitory function of Wnt5a (show WNT5A Antibodies) in glutamatergic synapse formation. We also revealed the opposing roles of Wnt (show WNT2 Antibodies)-regulated planar cell polarity components, Celsr3 (show CELSR3 Antibodies) and Vangl2, in glutamatergic synapse formation.

5. Exogenously introduced expression of green fluorescent protein (GFP)-tagged core PCP (show BMP1 Antibodies) factors by electroporation revealed that Vangl1 (show Vangl1 Antibodies), Vangl2 and Prickle2 (show PRICKLE2 Antibodies) are localized on the ovarian side of the cell periphery in the oviduct.Our data collectively suggest that the mechanism for maintenance of Vangl2 asymmetry in mature mouse oviduct is different from the microtubule dependent polarized transport model

6. heterozygous Looptail (Lp) mice, in which a single copy of the core PCP (show BMP1 Antibodies) gene, Vangl2, is disrupted are viable but display severe airspace enlargement and impaired adult lung function.

7. interacts with Celsr1 (show CELSR1 Antibodies) in ureteric tree growth

8. Vangl2 is expressed in the inner dental epithelium (IDE (show IDE Antibodies)) and in the secondary enamel knots (SEKs) of bell stage tooth germs.

9. a new and essential role for Vangl2-dependent planar cell polarity signaling in the intraretinal path-finding of retinal ganglion cell axons

10. Vangl2-regulated polarisation and subsequent acquisition of an epithelial phenotype is essential to lengthen the tubular outflow vessel, a process that is essential for on-going cardiac morphogenesis (show XIRP1 Antibodies).

Zebrafish Vang-Like 2 (Van Gogh, Drosophila) (VANGL2) interaction partners

1. Results demonstrate that anterior guidance decisions by commissural primary ascending (CoPA (show COPA Antibodies)) axons are dependent on the function of planar cell polarity genes Fzd3a, Vangl2 and Scribble (show SCRIB Antibodies) both prior to and after midline crossing; experiments establish CoPA (show COPA Antibodies) axons as a model system to investigate the mechanism of planar cell polarity signaling in commissural axon guidance.

2. dynamic Vangl2 intracellular distribution is coordinated with and necessary for the changes in convergence and extension cell behaviors during gastrulation

3. we found that the critical period for Vangl2 function coincides with the initial stages of FBM neuron migration out of rhombomere 4.

4. Vangl2 regulates FBM neuron migration by acting in floor plate cells, independently of cilia function

5. VANGL2 regulates the endocytosis and cell-surface availability of MMP14 in a manner that is dependent on focal adhesion kinase.

6. Vangl2(R259L) behaved like the wild-type allele in overexpression and morpholino knockdown/rescue assays in zebrafish embryos.

7. Rack1 (show GNB2L1 Antibodies) has a dominant-negative effect on Vangl2 localization and gastrulation.

8. data suggest that bbs8 (show TTC8 Antibodies) and vangl2 act synergistically on cell polarization to establish and maintain the appropriate length and number of cilia in the Kupffer's vesicle and thereby facilitate correct LR asymmetry

9. Vangl2 is required for asymmetric localization and posterior tilting of primary motile cilia at the apical membrane of epithelial cells.

10. show that anterior hindbrain (r2/r3) motor neuron migration appears to be independent of vangl2 and pk1b functions, and suggest that multiple mechanisms regulate motor neuron migration along the anterior-posterior axis of the zebrafish hindbrain

Human Vang-Like 2 (Van Gogh, Drosophila) (VANGL2) interaction partners

1. VANGL2 interacts with Integrin alphaVbeta3 to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.

2. Our experimental data demonstrate that high expression of Prickle1 (show PRICKLE1 Antibodies) and Vangl2 reduce the growth of neuroblastoma (show ARHGEF16 Antibodies) cells and indicate different roles of PCP (show PRCP Antibodies) proteins in tumorigenic cells compared to normal cells.

3. VANGL2 is overexpressed in basal breast cancers. It is involved in the proliferative signal cascade of the VANGL2-SQSTM1 (show SQSTM1 Antibodies)-JNK (show MAPK8 Antibodies) pathway.

4. Propose that Arfrp1 (show ARFRP1 Antibodies) exposes a binding site on AP-1 (show FOSB Antibodies) that recognizes the Vangl2 sorting motif for capture into a transport vesicle destined for the proximal surface of a polarized epithelial cell.

5. The aberrant VANGL2 promoter methylation and the decreased gene expression is associated with Tetralogy of Fallot.

6. Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT (show WNT2 Antibodies)/planar cell polarity pathway.

7. Van-Gogh-like 2 is frequently methylated in MSI (show MSI1 Antibodies)-CRCs with BRAF (show BRAF Antibodies) mutation and may act as a tumour suppressor gene, counteracting WNT (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.

8. these findings strongly implicate VANGL2 in the genetic causation of spinal NTDs in a subset of patients and provide additional evidence for a pathogenic role of PCP (show PRCP Antibodies) signaling in these malformations.

9. Loss of membrane targeting of Vangl1 (show Vangl1 Antibodies) and Vangl2 proteins causes neural tube defects.

10. The planar cell polarity genes Celsr1 (show CELSR1 Antibodies) and Vangl2 are required for normal lung branching morphogenesis.