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Browse our anti-AKR1C4 (AKR1C4) Antibodies

Full name:: anti-Aldo-keto Reductase Family 1 Member C4 Antibodies (AKR1C4)

On www.antibodies-online.com are 88 Aldo-keto Reductase Family 1 Member C4 (AKR1C4) Antibodies from 22 different suppliers available. Additionally we are shipping AKR1C4 Proteins (12) and AKR1C4 Kits (8) and many more products for this protein. A total of 113 AKR1C4 products are currently listed.

Synonyms:: 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA

list all antibodies	Gene Name	GeneID	UniProt
	AKR1C4	1109	P17516
	AKR1C4
	AKR1C4
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Most Popular Reactivities for anti-AKR1C4 (AKR1C4) Antibodies

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anti-Human AKR1C4 Antibodies:

anti-Mouse (Murine) AKR1C4 Antibodies:

15 WB Antibodies

anti-Rat (Rattus) AKR1C4 Antibodies:

14 WB Antibodies

All available anti-AKR1C4 Antibodies

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Relevant Pathways for anti-AKR1C4 Antibodies

Steroid Hormone Biosynthesis

More product categories related to AKR1C4 Antibody

Top referenced anti-AKR1C4 Antibodies

Human Polyclonal AKR1C4 Primary Antibody for ELISA, WB - ABIN547673 : Lord, Mack, Van Den Berg, Pike, Ingles, Haiman, Wang, Parisky, Hodis, Ursin: Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study. in Breast cancer research : BCR 2005 (PubMed)
Human Monoclonal AKR1C4 Primary Antibody for IF, IHC (p) - ABIN560358 : Stayrook, Rogers, Savkur, Wang, Su, Varga, Bu, Wei, Nagpal, Liu, Burris: Regulation of human 3 alpha-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor alpha. in Molecular pharmacology 2008 (PubMed)
Human Polyclonal AKR1C4 Primary Antibody for WB - ABIN514376 : Ebert, Kisiela, Wsól, Maser: Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. in Chemico-biological interactions 2011 (PubMed)

More Antibodies against AKR1C4 Interaction Partners

Human Aldo-keto Reductase Family 1 Member C4 (AKR1C4) interaction partners

the present study suggests that AKR1C1, AKR1C2, AKR1C3, and AKR1C4 are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.
Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency.
In women only, SNPs in AKR1C4 reduced the likelihood of having exhibited paranoid ideation by circa 60%.
Low progesterone levels and a cystine to serine change at position 145 in AKR1C4 gene are associated with manic/hypomanic irritability in males
role of AKR1C4 in the metabolism of testosterone and progesterone via the 5beta-reductase pathway.
Taken together, we conclude that the cell-type-specific expression of DD4 mRNA is regulated by vHNF-1-C.
the expression level of DD4 mRNA is cooperatively regulated by the amounts of HNF-1 alpha, HNF-4 alpha and HNF-4 gamma.
Impact of mirtazapine on the activity of a key neurosteroidogenic enzyme, the 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD), and on the levels of neuroactive steroids in relation to clinical response in depression.
Structure determination of human AKR1C4 and homology modelling of AKR1D1 followed by docking experiments were used to explore active site geometries.

AKR1C4 Antigen Profile

Antigen Summary

This gene encodes a member of the aldo\\/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and\\/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Alternative names and synonyms associated with AKR1C4

aldo-keto reductase family 1 member C4 (AKR1C4) antibody

3-alpha-HSD antibody
C11 antibody
CDR antibody
CHDR antibody
DD-4 antibody
DD4 antibody
HAKRA antibody

Protein level used designations for AKR1C4

3-alpha-HSD1 , aldo-keto reductase family 1 member C4 , chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4 , dihydrodiol dehydrogenase isozyme DD4 , type I 3-alpha-hydroxysteroid dehydrogenase

GENE ID	SPECIES
1109	Homo sapiens

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Show all anti-Aldo-keto Reductase Family 1 Member C4 (AKR1C4) Antibodies with Pubmed References

Human Aldo-keto Reductase Family 1 Member C4 (AKR1C4) interaction partners

Antigen Summary

Alternative names and synonyms associated with AKR1C4

Protein level used designations for AKR1C4