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Human Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1) interaction partners

1. Juvenile onset open angle glaucoma and adult onset POAG form a spectrum of phenotypes. we analyzed the common variants in MYOC (show MYOC Antibodies) and CYP1B1 that were shared among all the three phenotypes .An interesting finding was that, while, many CYP1B1 variants were found in all three types of glaucoma, there was no reported MYOC (show MYOC Antibodies) variant, that was common to all the three primary glaucomas.

2. The frequency of p.E229K and p.R368H mutations of the CYP1B1 gene is low even among sporadic JOAG (show MYOC Antibodies) patients.

3. This pilot study revealed a significant association of the CYP1B1 Asn453Ser genotypes with the plasma levels of HDL (show HSD11B1 Antibodies)-cholesterol and of apolipoprotein A1 (show APOA1 Antibodies) in postmenopausal women and less unequivocal findings in premenopausal women.

4. We present an uncommon mutation and clinical description of CYP1B1 gene analysis demonstrated homozygosity for a 1-bp deletion in exon 2 (c.830delT).

5. In summary, these data expand the mutational and phenotypic spectra of CYP1B1 to include two novel alleles and additional developmental ocular phenotypes. The contribution of CYP1B1 to primary open angle glaucoma (POAG) is less clear, but loss-of-function variants in CYP1B1, especially c.1064_1076del, p.(Arg355Hisfs*69), may be associated with an increased risk for POAG.

6. In summary, a KLE cell-based model has been characterized to be suitable for identifying CYP1B1-targeted anticancer prodrugs and should be further developed and employed for screening chemical libraries.

7. AHR (show AHR Antibodies), CYP1A1 (show CYP1A1 Antibodies), CYP1A2 (show CYP1A2 Antibodies), or CYP1B1 variants associated with head-and-neck squamous cell carcinoma risk in smokers.

8. Our study identified nine different CYP1B1 mutations in 73.3% of the primary congenital glaucoma patients.

9. Our larger cohort suggests a tendency for girls with bi-allelic CYP1B1 mutations to have a more severe congenital phenotype as opposed to later-onset disease.

10. Increased expression of CYP1B1 is associated with ovarian/peritoneal endometriotic lesions.

Mouse (Murine) Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1) interaction partners

1. Hepc (show HAMP Antibodies) decreases in Cyp1b1-/- and gestational vitamin A deficiency mice resulted in stellate activation and lipogenesis suppression.

2. Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, the study tested the hypothesis that hCYP1B1 is important for dibenzo[def,p]chrysene (DBC) transplacental carcinogenesis. hCYP1B1 genotype did not impact lung tumor multiplicity, but tended to enhance incidence compared to Cyp1b1 wild-type mice (P = 0.07).

3. CYP1B1 contributed to the development of Ang II (show AGT Antibodies)-induced abdominal aortic aneurysm and associated pathogenic events in mice, likely by enhancing oxidative stress and associated signaling events

4. Miroestrol suppressed beta-naphthoflavone increases in CYP1B1.

5. Findings provide evidence that CYP1B1 is directly involved in the development of cardiac hypertrophy.

6. Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4alpha (show HNF4A Antibodies) and PPARalpha (show PPARA Antibodies).

7. hypertension, and associated pathogenesis in ApoE (show APOE Antibodies)(-/-)/Cyp1b1(+/+) mice on an atherogenic diet are most likely dependent on CYP1B1-generated oxidative stress and increased plasma lipid levels independent of blood pressure and absorption of lipids.

8. Follicle stimulating hormone functions via p38 MAPK (show MAPK14 Antibodies)-induced dephosphorylation at Ser (show SIGLEC1 Antibodies)(727) of STAT1 (show STAT1 Antibodies) to downregulate Cyp1b1 expression and maintain the estradiol levels in mouse dominant follicles.

9. Cyp1b1 contributes to angiotensin II induced hypertension and its pathogenesis in male mice.

10. Suggest that Cyp1b1 plays a critical role in female mice in protecting against renal dysfunction and end-organ damage associated with ANG II (show AGT Antibodies)-induced hypertension.

Zebrafish Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1) interaction partners

1. CYP1B1 knockdown studies show CYP1B1 is not a significant factor in causing synergistic toxicity of PAHs, nor, in contrast to CYP1A, in providing protection