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Human Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1) interaction partners

1. These findings suggest that CYP1B1 promotes cancer cell survival through involvement of DNA methylation-mediated DR4 inhibition and that Sp1 may act as key mediator required for oncogenic action.

2. All cases that lacked biallelic CYP1B1 mutations underwent whole exome sequencing.

3. Identities and frequencies of variants in CYP1B1 causing primary congenital glaucoma in Pakistan have been reported.

4. This study found that L107V and R390H in CYP1B1 are two common mutations relating to primary congenital glaucoma in Chinese populations. Both mutations may destroy the residue contacts, destabilize the local and/or whole protein, reduce the exposure of active sites, and finally affect the molecular interactions between CYP1B1 and the substrate.

5. While MYOC damaging alterations were highly prevalent (34%), CYP1B1 damaging variants were less frequent (2%) in this cohort of Brazilian juvenile open angle glaucoma patients.

6. Heterozygous pathogenic variants in the PITX2 and FOXC1 genes accounted for 66% (6/9) of the ARS/ASD cases. The absence of PAX6 or CYP1B1 abnormalities could reflect our small sample size, although their analysis could be justified in ARS/ASD patients that present with congenital glaucoma or aniridia.

7. CYP1B1 142C-4326G haplotype and high CYP1B1 mRNA expression was associated with higher risk for chemoresistance in triple negative breast cancer.

8. The aim of this study was to investigate serum concentrations of AhR, cytochromes P450 (CYP) 1A1 and 1B1 in patients with exacerbated psoriasis vulgaris.

9. Our findings suggest a relationship between the CYP1B1-rs1056836 genetic polymorphism and clinical features of squamous cell carcinoma of the esophagus , supporting further studies in larger populations in different ethnic groups, taking into account potentially important environmental factors such as diet.

10. CYP1B1 single nucleotide polymorphisms association with lung cancer susceptibility in Polish smokers.

11. Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants

12. An increased breast cancer risk, independent of other breast cancer risk factors, was observed among carriers of CYP1B1 G119T genotype.

13. CYP1B1 mRNA expression in the preputial tissues from patients with hypospadias and phimosis

14. the CYP1B1 status in tissues from 76 patients diagnosed with non-small cell lung cancer, was investigated.

15. High CYP1B1 expression is associated with prostate cancer.

16. Data provide evidence that CYP1B1 plays a critical role in polycyclic aromatic hydrocarbon-mediated DNA damage.

17. genetic association studies in population of postmenopausal Mexican-Mestizo women: Data suggest SNPs in CYP1A1 (rs1799814, rs1048943; but not rs1056836 in CYP1B1) are associated with postmenopausal osteoporosis in the population studied; SNPs in CYP1A1 are associated with low bone mineral density in lumbar spine and femur neck. (CYP1A1 = aryl hydrocarbon hydroxylase CYP1A1; CYP1B1 = aryl hydrocarbon hydroxylase CYP1B1)

18. Juvenile onset open angle glaucoma and adult onset POAG form a spectrum of phenotypes. we analyzed the common variants in MYOC and CYP1B1 that were shared among all the three phenotypes .An interesting finding was that, while, many CYP1B1 variants were found in all three types of glaucoma, there was no reported MYOC variant, that was common to all the three primary glaucomas.

19. The frequency of p.E229K and p.R368H mutations of the CYP1B1 gene is low even among sporadic JOAG patients.

20. This pilot study revealed a significant association of the CYP1B1 Asn453Ser genotypes with the plasma levels of HDL-cholesterol and of apolipoprotein A1 in postmenopausal women and less unequivocal findings in premenopausal women.

Mouse (Murine) Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1) interaction partners

1. expression has a significant impact on liver sinusoidal endothelial cells angiogenic and inflammatory functions

2. Hepc decreases in Cyp1b1-/- and gestational vitamin A deficiency mice resulted in stellate activation and lipogenesis suppression.

3. Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, the study tested the hypothesis that hCYP1B1 is important for dibenzo[def,p]chrysene (DBC) transplacental carcinogenesis. hCYP1B1 genotype did not impact lung tumor multiplicity, but tended to enhance incidence compared to Cyp1b1 wild-type mice (P = 0.07).

4. CYP1B1 contributed to the development of Ang II-induced abdominal aortic aneurysm and associated pathogenic events in mice, likely by enhancing oxidative stress and associated signaling events

5. Miroestrol suppressed beta-naphthoflavone increases in CYP1B1.

6. Findings provide evidence that CYP1B1 is directly involved in the development of cardiac hypertrophy.

7. Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4alpha and PPARalpha.

8. hypertension, and associated pathogenesis in ApoE(-/-)/Cyp1b1(+/+) mice on an atherogenic diet are most likely dependent on CYP1B1-generated oxidative stress and increased plasma lipid levels independent of blood pressure and absorption of lipids.

9. Follicle stimulating hormone functions via p38 MAPK-induced dephosphorylation at Ser(727) of STAT1 to downregulate Cyp1b1 expression and maintain the estradiol levels in mouse dominant follicles.

10. Cyp1b1 contributes to angiotensin II induced hypertension and its pathogenesis in male mice.

11. Suggest that Cyp1b1 plays a critical role in female mice in protecting against renal dysfunction and end-organ damage associated with ANG II-induced hypertension.

12. Data indicaate that adduct formation in cytochrome P450 Cyp1b1 knockout mice was significantly reduced compared to wild-type mice receiving dibenzo[def,p]chrysene (DBC).

13. Cyp1b1 deletion substantially alters the expression of genes associated with fatty acid homeostasis

14. Data indicate that hepatic stearoyl-CoA desaturase 1 (SCD1) expression was decreased in cytochrome P450 1B1 (CYP1B1)-null mice.

15. Using inhibitors of p38 and MSKs, as well as mouse embryonic cells derived from p38alpha-deficient and MSK1/2 double knockout mice, we show here that TNF-alpha potentiates CYP1B1 upregulation via the p38/MSK1 kinase cascade

16. a direct role for mitochondrial CYP1B1 in PAH-mediated oxidative and chemical damage to mitochondria.

17. Cyp1B1 expression in vascular cells plays an important role in the regulation of the cellular reductive state, thrombospondin (TSP)2 expression, and NF-kappaB activation.

18. Metabolic activity of CYP1B1 contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of Postn expression.

19. In the present study we show that [a] NQO1 protein locates to cytosol, ER and mitochondria.

20. important role for Cyp1B1 expression in the regulation of pericyte proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappaB expression and/or activity

Zebrafish Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1) interaction partners

1. CYP1B1 knockdown studies show CYP1B1 is not a significant factor in causing synergistic toxicity of PAHs, nor, in contrast to CYP1A, in providing protection