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anti-Human CYP3A4 Antibodies:
anti-Mouse (Murine) CYP3A4 Antibodies:
anti-Rat (Rattus) CYP3A4 Antibodies:
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Human Polyclonal CYP3A4 Primary Antibody for IHC (p), WB - ABIN514838
Yamashita, Honda, Nio, Nakamoto, Yamashita, Takamura, Tani, Zen, Kaneko: Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation. in Cancer research 2010
Show all 3 Pubmed References
Human Monoclonal CYP3A4 Primary Antibody for ICC, FACS - ABIN969512
van Waterschoot, Rooswinkel, Sparidans, van Herwaarden, Beijnen, Schinkel: Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam. in Drug metabolism and disposition: the biological fate of chemicals 2009
Show all 2 Pubmed References
Human Polyclonal CYP3A4 Primary Antibody for Func, WB - ABIN2473177
Chirkov YuYu, Tyshchuk, Severina: Guanylate cyclase in human platelets with different aggregability. in Experientia 1990
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Human Polyclonal CYP3A4 Primary Antibody for WB - ABIN269568
Buchanan, Meng, Poulin, Zuccolo, Azike, Gabriele, Baranowski: Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine. in PLoS ONE 2018
Human Polyclonal CYP3A4 Primary Antibody for FACS, IF - ABIN652422
Okamatsu, Kawakami, Komatsu, Kitazawa, Uno, Teraoka: Functional expression and comparative characterization of four feline P450 cytochromes using fluorescent substrates. in Xenobiotica; the fate of foreign compounds in biological systems 2017
Human Polyclonal CYP3A4 Primary Antibody for ELISA - ABIN4302113
Choi, Skipper, Wishnok, Tannenbaum: Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450. in Drug metabolism and disposition: the biological fate of chemicals 2005
Cow (Bovine) Polyclonal CYP3A4 Primary Antibody for WB - ABIN2784528
Werk, Lefeldt, Bruckmueller, Hemmrich-Stanisak, Franke, Roos, Küchle, Steubl, Schmaderer, Bräsen, Heemann, Cascorbi, Renders: Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance. in Clinical pharmacology and therapeutics 2014
Human Polyclonal CYP3A4 Primary Antibody for WB - ABIN514839
De Bock, Colin, Boussery, Van Bocxlaer: Development and validation of an enzyme-linked immunosorbent assay for the quantification of cytochrome 3A4 in human liver microsomes. in Talanta 2012
Human Polyclonal CYP3A4 Primary Antibody for IP, WB - ABIN947776
Fujiwara, Itoh: Extensive protein interactions involving cytochrome P450 3A4: a possible contributor to the formation of a metabolosome. in Pharmacology research & perspectives 2014
The genetic polymorphisms of the multi-drug resistance-1 (MDR-1 (show TBC1D9 Antibodies)) and human cytochrome P450 (show CYP Antibodies) 3A (CYP3A4 and CYP3A5 (show CYP3A5 Antibodies)) genes were analyzed and compared between steroid sensitive, steroid resistant and control groups.
this meta-analysis suggests that the CYP3A4*1B polymorphism might play a modest role in susceptibility to cancer, especially for leukemia.
JNK (show MAPK8 Antibodies) is a novel mechanistic regulator of CYP3A4 induction by PXR (show NR1I2 Antibodies).
The other four metabolites were almost exclusively metabolized by CYP3A4.
It observed an increase in the activity of CYP3A following but not during pregnancy when measured using the 4beta-hydroxycholesterol/cholesterol ratio. In addition, based on our results, it suggestes that the plasma 4beta-hydroxycholesterol/cholesterol ratio be used to measure CYP3A activity in pregnant women.
These findings also suggest that EGF (show EGF Antibodies) may be an important regulator of CYP3A4 expression in vivo.
our results indicate that a significant level of MDR1 (show TBC1D9 Antibodies) mRNA, but not CYP3A4 mRNA, is intrinsically present before chemotherapy in advanced STS (show STS Antibodies) tumors.
A weak-to-moderate CYP3A4 induction by midostaurin.
CYP3A4 *18B and GCK (show GCK Antibodies) G-30A polymorphisms were related to new-onset diabetes after transplantation (p < 0.05). The lower concentration/dose or fasting serum glucose was in CYP3A4 *1/*1 carriers than that in *18B/*18B carriers in all the renal transplant recipients (p < 0.05), respectively.
Data suggest high similarity in mechanisms involved in regulation of expression of pig CYP3A29 and human CYP3A4 in hepatocytes.
It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Antibodies) and cytochrome b(5 (show CYB5A Antibodies)).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
, P450-III, steroid inducible
, albendazole monooxygenase
, albendazole sulfoxidase
, cytochrome P450 3A3
, cytochrome P450 3A4
, cytochrome P450 HLp
, cytochrome P450 NF-25
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
, cytochrome P450-PCN1
, glucocorticoid-inducible P450
, nifedipine oxidase
, quinine 3-monooxygenase
, taurochenodeoxycholate 6-alpha-hydroxylase
, cytochrome P450, family 3, subfamily A, polypeptide 4
, cytochrome P450 3A80
, Cytochrome P450 CM3A-10
, cytochrome P450 3A21
, cytochrome P450 CYP3A12