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anti-Human CYP3A4 Antibodies:
anti-Rat (Rattus) CYP3A4 Antibodies:
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Human Polyclonal CYP3A4 Primary Antibody for IHC (p), WB - ABIN514838
Yamashita, Honda, Nio, Nakamoto, Yamashita, Takamura, Tani, Zen, Kaneko: Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation. in Cancer research 2010
Show all 3 Pubmed References
Human Polyclonal CYP3A4 Primary Antibody for Func, WB - ABIN2473177
Chirkov YuYu, Tyshchuk, Severina: Guanylate cyclase in human platelets with different aggregability. in Experientia 1990
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Human Monoclonal CYP3A4 Primary Antibody for ICC, FACS - ABIN969512
van Waterschoot, Rooswinkel, Sparidans, van Herwaarden, Beijnen, Schinkel: Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam. in Drug metabolism and disposition: the biological fate of chemicals 2009
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Human Polyclonal CYP3A4 Primary Antibody for IP, WB - ABIN947776
Fujiwara, Itoh: Extensive protein interactions involving cytochrome P450 3A4: a possible contributor to the formation of a metabolosome. in Pharmacology research & perspectives 2014
Human Polyclonal CYP3A4 Primary Antibody for WB - ABIN514839
De Bock, Colin, Boussery, Van Bocxlaer: Development and validation of an enzyme-linked immunosorbent assay for the quantification of cytochrome 3A4 in human liver microsomes. in Talanta 2012
Cow (Bovine) Polyclonal CYP3A4 Primary Antibody for WB - ABIN2784528
Werk, Lefeldt, Bruckmueller, Hemmrich-Stanisak, Franke, Roos, Küchle, Steubl, Schmaderer, Bräsen, Heemann, Cascorbi, Renders: Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance. in Clinical pharmacology and therapeutics 2014
Human Polyclonal CYP3A4 Primary Antibody for ELISA - ABIN4302113
Choi, Skipper, Wishnok, Tannenbaum: Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450. in Drug metabolism and disposition: the biological fate of chemicals 2005
In oral contraceptive users, haplotype A and B in the CYP3A4 gene were associated with venous thrombosis risk, but not in non-users; however, the effect on Sex-hormone-binding-globulin (show SHBG Antibodies) levels was not directional with the risk.
The combined CYP3A4 and CYP3A5 (show CYP3A5 Antibodies) genotype of renal transplant recipients has a major influence on the Tacrolimus dose required to reach the target exposure.
We solved the 2.7 A crystal structure of the CYP3A4-midazolam (MDZ) complex, where the drug is well defined and oriented suitably for hydroxylation of the C1 atom, the major site of metabolism. This binding mode requires H-bonding to Ser119 and a dramatic conformational switch in the F-G fragment, which transmits to the adjacent helices, resulting in a collapse of the active site cavity and MDZ immobilization.
our findings suggest that CYP1A2 (show CYP1A2 Antibodies), CYP3A4 and CYP3A5 (show CYP3A5 Antibodies) play an important role in osteosarcoma tumorigenesis, at primary and metastatic sites, as well in treatment response
Our results provide information on CYP3A4 polymorphisms in Tibetan individuals which may help to optimize pharmacotherapy effectiveness by providing personalized medicine to this ethnic group.
Among two SNPs in CYP3A4 and CYP3A5 (show CYP3A5 Antibodies) and 12 SNPs in ABCB1 (show ABCB1 Antibodies) gene, an association with ovarian cancer risk was observed for ABCB1 (show ABCB1 Antibodies) rs2157926 SNP only.
Low CYP3A4 Activity is associated with Crohn's Disease.
Cryopreserved human hepatocytes can be stored stably for more than a decade with little or no change in CYP3A4/5 induction.
Associations between SLCO1B1 (show SLCO1B1 Antibodies) 521C and cholesterol response were not detected in African Americans (n = 333). Associations between CYP3A4*22 or CYP3A5 (show CYP3A5 Antibodies)*3 and cholesterol response were not detected in whites or African Americans.
This kdeg value for CYP3A4 was in good agreement with recently reported values.
It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Antibodies) and cytochrome b(5 (show CYB5A Antibodies)).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
, P450-III, steroid inducible
, albendazole monooxygenase
, albendazole sulfoxidase
, cytochrome P450 3A3
, cytochrome P450 3A4
, cytochrome P450 HLp
, cytochrome P450 NF-25
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
, cytochrome P450-PCN1
, glucocorticoid-inducible P450
, nifedipine oxidase
, quinine 3-monooxygenase
, taurochenodeoxycholate 6-alpha-hydroxylase
, cytochrome P450, family 3, subfamily A, polypeptide 4
, cytochrome P450 3A80
, Cytochrome P450 CM3A-10
, cytochrome P450 3A21
, cytochrome P450 CYP3A12