CYP3A4 antibody (AA 242-270)

Catalog No. ABIN652422

Cited in 1 publication. The Rabbit Polyclonal anti-CYP3A4 antibody (Clone RB16656) (ABIN652422) specifically detects CYP3A4 in WB, IF and FACS. The antibody is reactive with Human samples.

Quick Overview for CYP3A4 antibody (AA 242-270) (ABIN652422)

Target: CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP3A4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: RB16656

Product Details anti-CYP3A4 Antibody

Binding Specificity: AA 242-270

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This CYP3A43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-270 amino acids from the Central region of human CYP3A43.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:2000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-CYP3A4 antibody (ABIN652422)

Okamatsu, Kawakami, Komatsu, Kitazawa, Uno, Teraoka: "Functional expression and comparative characterization of four feline P450 cytochromes using fluorescent substrates." in: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 47, Issue 11, pp. 951-961, (2017) (PubMed).

Target Details for CYP3A4

Target: CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))

Alternative Name: CYP3A43

Background: CYP3A43 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, the protein unknown whether the enzyme is also involved in xenobiotic metabolism.

Molecular Weight: 57670

Gene ID: 64816

NCBI Accession: NP_001265850, NP_073731, NP_476436, NP_476437

UniProt: Q9HB55

Pathways: Steroid Hormone Biosynthesis