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our data indicate an alternative binding mode for testosterone in CYP3A7 that favors the 2alpha-hydroxylation, suggesting significant structural differences in its active site compared with CYP3A4 (show CYP3A4 Proteins)/5
Methylation status of cytosine in the CYP3A7 proximal promoter correlated with changes in developmental expression of mRNA.
Occupancy by modified histones was consistent with chromatin structural changes contributing to the mechanisms regulating CYP3A7 ontogeny.
All three neonicotinoid pesticides induced the expression of CYP3A7 in H295R cells; induction was reversed by co-treatment of H295R cells with exogenous estriol. CYP3A7 is normally expressed in fetal liver and is a key enzyme involved in estriol synthesis.
The CYP3A7*1C allele is associated with a lower urinary estrone levels, a more pronounced reduction in 2-hydroxylation pathway estrone metabolites (EMs) and a lower ratio of 2-hydroxylation:16alpha-hydroxylation EMs in premenopausal women.
data suggested that hepatocyte nuclear factor 4 alpha and glucocorticoid receptor, and epigenetic changes of H3K4me2 and H3K27me3 are associated with the ontogenic expressions of CYP3A4/3A7 in the livers of the Chinese Han population.
These results suggest the existence of a marked inter-individual variability regarding the presence of the isoforms of CYP3A (show CYP3A4 Proteins). In addition, since sorafenib is metabolized by CYP3A4 (show CYP3A4 Proteins), but not by CYP3A7, an overexpression of CYP3A4 (show CYP3A4 Proteins) may lead to an increase in the degradation of the drug and then to clinical ineffectiveness.
CYP3A7*1C influences outcome are required.
CYP3A4 (show CYP3A4 Proteins), CYP3A7, UGT2B11 and UGT2B15 (show UGT2B15 Proteins) genes are significantly downregulated in melanosis coli.
Differences in the expression of nuclear receptors might determine the variability in CYP3A4 (show CYP3A4 Proteins) and CYP3A7 expression observed in foetal liver.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced. This gene undergoes readthrough transcription with the downstream CYP3AP1 pseudogene, resulting in an isoform with a novel C-terminus, as represented in GeneID:100861540.
cytochrome P450 3A7
, aryl hydrocarbon hydroxylase
, cytochrome P450, subfamily IIIA, polypeptide 7
, cytochrome P450-HFLA
, flavoprotein-linked monooxygenase
, microsomal monooxygenase
, xenobiotic monooxygenase