Browse our Cytochrome P450, Family 4, Subfamily F, Polypeptide 3 Proteins (CYP4F3)

Human Cytochrome P450, Family 4, Subfamily F, Polypeptide 3 (CYP4F3) interaction partners

1. High n3:n6 polyunsaturated fatty acids (PUFA) intake was associated with a reduced risk of ulcerative colitis (UC) in individuals with the GG/AG genotype at a single nucleotide polymorphism in CYP4F3 but not those with the AA genotype. The association between dietary n3:n6 PUFA intake and risk of UC may be modified variants at CYP4F3.

2. The results suggest that a potentially functional single-nucleotide polymorphisms in CYP4F3 (rs4646904) may contribute to the etiology of lung cancer, especially in smokers.

3. Children who consumed a higher dietary ratio of omega6/omega3 were susceptible for Crohn's disease if they were also carriers of specific variants of CYP4F3 and FADS2 (show FADS2 Proteins) genes.

4. In this short review, emphasis will be placed on the regulation and the functional roles of human CYP4F3--{REVIEW}

5. can directly stimulate osteoclast differentiation dependent of RANKL (show TNFSF11 Proteins)

6. identification of the distinct transcriptional features in myeloid, lymphoid, and hepatic cells that indicate the presence of multiple promoters in the CYP4F3 gene

7. CYP4F18 is a critical protein in the regulation of LTB(4 (show PTGR1 Proteins)) metabolism

8. 3-hydroxystearate and 3-hydroxypalmitate are converted to omega-hydroxylated 3-OHDCA precursors in liver; CYP4F11 and, to a lesser extent, CYP4F2 catalyzed omega-hydroxylation of 3-hydroxystearate; CYP4F3b, CYP4F12, and CYP4A11 had negligible activity.

9. By regulating the balance of LTB4 (show PTGR1 Proteins) in the lung, LTB4OH may function as a suppressor of lung carcinogenesis.

Mouse (Murine) Cytochrome P450, Family 4, Subfamily F, Polypeptide 3 (CYP4F3) interaction partners

1. CYP4F18-deficient neutrophils exhibit increased chemotaxis to complement component C5a.

2. It is concluded that CYP4F18 is necessary for omega oxidation of leukotriene B4 in neutrophils, and is not compensated by other CYP (show PPIG Proteins) enzymes

3. CYP4F18 is a critical protein in the regulation of LTB(4 (show PTGR1 Proteins)) metabolism

4. The mRNA levels of Cyp4f18 increase with the development of allergic inflammation in the lung.