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anti-Human CYP7A1 Antibodies:
anti-Mouse (Murine) CYP7A1 Antibodies:
anti-Rat (Rattus) CYP7A1 Antibodies:
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Human Polyclonal CYP7A1 Primary Antibody for IF (p), IHC (p) - ABIN739725
Gabbi, Bertolotti, Anzivino, Macchioni, Del Puppo, Ricchi, Carubbi, Tagliafico, Romagnoli, Odoardi, Loria, Losi, Carulli: Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease. in Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2012
Show all 6 Pubmed References
Current studies suggest that increased Cyp7a1 expression and bile acid synthesis ameliorate hepatic inflammation through activation of FXR (show NR1H4 Antibodies)
This study provides evidence that individuals carrying the G allele of CYP7A1 single nucleotide polymorphism are more responsive to high molecular weight beta-glucan's effect of lowering circulating cholesterol concentrations than individuals homozygous for the T allele.
Genetic variations in ABCG5 (show ABCG5 Antibodies), CYP7A1, and DHCR7 (show DHCR7 Antibodies) may contribute to differing responses of serum cholesterol to dairy intake among healthy adults.
The promoter polymorphism of the CYP7A1 gene has a pronounced impact on diurnal variation in CYP7A1 activity.
The finding that overexpression of HIF-1alpha (show HIF1A Antibodies) increased the activity of the CYP7A1 promoter suggested that hypoxia decreased the expression of CYP7A1 in a HIF-1 (show HIF1A Antibodies)-independent manner.
Macrophage cholesterol efflux in patients with type II diabetes mellitus was significantly reduced, and that this reduction was associated with the down-regulation of CYP7A1 expression.
CYP7A1 and APOE (show APOE Antibodies) isoform are associated with the extent of reduction in circulating LDL cholesterol in response to plant sterols consumption.
The CYP7A1 rs7833904 polymorphism may modify the risk of CAD (show CAD Antibodies).
The CYP7A1 crystallographic models identify residues involved in cholest-4-en-3 (show EN1 Antibodies)-one binding.
we identified for the first time a significant association of the A-204C polymorphism of the CYP7A1 gene and development of tuberculosis in a Moroccan population
although feeding LS-Xbp1 (show XBP1 Antibodies)(-/-) mice cholesterol did not increase CYP7A1 expression, serum C4 levels increased significantly up to levels similar to chow-fed Xbp1 (show XBP1 Antibodies)(fl/fl (show FLT3LG Antibodies)) mice and the total bile acid pool normalized. In conclusion, loss of hepatic XBP1 (show XBP1 Antibodies) decreased the bile acid pool and CYP7A1 synthetic activity.
Cyp7a1(-/-) mice have improved glucose sensitivity with reduced liver triglycerides and fecal bile acid excretion, but increased fecal fatty acid excretion and respiratory exchange ratio (RER) when fed a high-fat/high-cholesterol diet
HSF-1 (show HSF1 Antibodies) ablation not only eliminates heat shock response, but it also transcriptionally up-regulates CYP7A1 and MDR1/P-gp (show ABCB4 Antibodies) axis in WD-diet fed HSF-1 (show HSF1 Antibodies)(-/-)/LDLr (show LDLR Antibodies)(-/-) mice to reduce atherosclerosis.
Mice deficient in cholesterol 7 alpha-hydroxylase, supplemented with chenodeoxycholic acid, have altered liver and intestinal bile acids.
Activation of the VDR (show CYP27B1 Antibodies) represses hepatic SHP (show LAMC1 Antibodies) to increase levels of CYP7A1 and reduce cholesterol.
Cholesterol lowering properties of oats involve increased production of bile acids via the classic pathway with up-regulation of CYP7A1 and CYP8B1 (show CYP8B1 Antibodies).
A CYP7A1/SREBP2 (show SREBF2 Antibodies)/miR (show MLXIP Antibodies)-33a axis plays a critical role in regulation of hepatic cholesterol, bile acid, and fatty acid synthesis.
Ileal Fibroblast Growth Factor-15 (FGF15) expression was significantly reduced in Asbt (show SLC10A2 Antibodies)(-/-)apoE (show APOE Antibodies)(-/-) mice and was inversely correlated with expression of hepatic cholesterol 7-hydroxylase (Cyp7a1).
HNF4alpha (show HNF4A Antibodies) and LRH-1 (show NR5A2 Antibodies) promote active transcription histone marks on the Cyp7a1 promoter that are reversed by FGF19 (show FGF19 Antibodies) in a SHP (show LAMC1 Antibodies)-dependent manner
the effect of polymorphism in the cholesterol 7-alpha hydroxylase gene locus and dietary cholesterol on cerebrum cholesterol in neonatal pigs fed sow's milk formulas are reported.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis.
, cholesterol 7-alpha-monooxygenase
, cytochrome P450 7A1
, cytochrome P450, subfamily VIIA polypeptide 1
, cholesterol 7 alpha hydroxylase
, cytochrome P450, 7a1
, cholesterol 7-alpha hydroxylase
, cytochrome P450 (cholesterol hydroxylase 7 alpha)
, cholesterol 7alpha-hydroxylase
, cholesterol 7 alpha-hydroxylase