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Data show that increased levels of AKR1C1/C2 enhanced the sensitivity of esophageal squamous cell carcinoma (ESCC) cells to ethyl-3,4-dihydroxybenzoate (EDHB).
the present study suggests that AKR1C1, AKR1C2 (show AKR1C2 ELISA Kits), AKR1C3 (show AKR1C3 ELISA Kits), and AKR1C4 (show AKR1C4 ELISA Kits) are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.
Activation of AKR1C1/ERbeta (show ESR2 ELISA Kits) induces apoptosis by downregulation of c-FLIP (show CFLAR ELISA Kits) in prostate cancer cells.
results suggest a gender-specific modulatory effect of AKR1C1 on anxiety levels, most likely through changes in progesterone and allopregnanolone levels within and outside the brain
Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 and AKR1C4 (show AKR1C4 ELISA Kits) are responsible for sexual development dysgenesis and mutations in AKR1D1 (show AKR1D1 ELISA Kits) are causative in bile-acid deficiency.
activation of the Nrf2 (show GABPA ELISA Kits)/AKR1C axis may contribute to oxaliplatin resistance in gastric carcinoma
The involvement of up-regulated AKR1C1, AKR1C3 (show AKR1C3 ELISA Kits) and proteasome in CDDP resistance of colon cancers.
Which promoted significant reduction of AKR1C1 and AKR1C2 (show AKR1C2 ELISA Kits) expression.
Data suggest that interleukin-1beta facilitates progesterone metabolism in cervical fibroblasts by regulating expression of AKR1C1 and AKR1C2 (show AKR1C2 ELISA Kits).
enhanced metabolism of progesterone by SRD5A1 (show SRD5A1 ELISA Kits) and the 20alpha-HSD and 3alpha/beta-HSD (show CHST3 ELISA Kits) activities of AKR1C1, AKR1C2 (show AKR1C2 ELISA Kits) and AKR1C3 (show AKR1C3 ELISA Kits)
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
20 alpha-hydroxysteroid dehydrogenase
, 20-alpha-hydroxysteroid dehydrogenase
, aldo-keto reductase C
, aldo-keto reductase family 1 member C1
, chlordecone reductase homolog HAKRC
, dihydrodiol dehydrogenase 1
, dihydrodiol dehydrogenase 1/2
, dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase
, dihydrodiol dehydrogenase isoform DD1
, hepatic dihydrodiol dehydrogenase
, high-affinity hepatic bile acid-binding protein
, indanol dehydrogenase
, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
, type II 3-alpha-hydroxysteroid dehydrogenase
, aldo-keto reductase family 1 member C1 homolog