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anti-Human HSD17B12 Antibodies:
anti-Rat (Rattus) HSD17B12 Antibodies:
anti-Mouse (Murine) HSD17B12 Antibodies:
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Human Polyclonal HSD17B12 Primary Antibody for ELISA, WB - ABIN565542
Cornel, Kruitwagen, Delvoux, Visconti, Van de Vijver, Day, Van Gorp, Hermans, Dunselman, Romano: Overexpression of 17?-hydroxysteroid dehydrogenase type 1 increases the exposure of endometrial cancer to 17?-estradiol. in The Journal of clinical endocrinology and metabolism 2012
The expression of HSD17B12 increased along with the severity of ovarian cancer, and the expression mimicked COX-2 expression and intensity. This further suggests the involvement of HSD17B12 in AA production, and its coexpression with COX-2 indicates a role for the enzyme in the increased prostaglandin production during ovarian cancer progression.
Significant associations have been found between CpG sites and patient sex, including DNA methylation in CASP6, a gene that may respond to estradiol treatment, and in HSD17B12, which encodes a sex steroid hormone.
These evidences were suggestive of a 46,XY DSD due to 17betaHSD3 deficiency. An homozygous mutation (IVS3 -1 G>C or c.326-1G>C) of the 17betaHSD3 gene was discovered.
HSD17B12 overexpression is shown to be a marker of poor survival in patients with ovarian cancer; expression in the tumor and function of this enzyme facilitates ovarian cancer progression.
High HSD17B12 expression is associated with neoplasms.
17beta-HSD12 is the major estrogenic 17beta-HSD responsible for the conversion of E1 to E2 in women.
Location of 17beta-hydroxysteroid dehydrogenase type 12 through the human body.
17beta-HSD12 is not \related to intratumoral estradiol biosynthesis in human breast carcinoma, but is correlated with production of very long chain fatty acids and tumor progresssion.
determined the activity and expression levels of known estrogenic 17beta-HSDs, namely types 1, 7 and 12 17beta-HSD in preadipocytes before and after differentiation into mature adipocytes
There is no difference in catalytic properties between variants of 17beta-HSD types 7 and 12 and wild-type enzymes, while variants p.Glu77Gly and p.Lys183Arg in 17beta-HSD type 5 showed a slightly decreased activity.
SREBP-1 represents one of the transcriptional regulators of human 17beta-HSD12.
important role in female fertility through its role in arachidonic acid metabolism
Hsd17b12 is essential for mouse organogenesis and embryonic survival.
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation.
, 17-beta-hydroxysteroid dehydrogenase 12
, 17beta-HSD type 12
, 3-ketoacyl-CoA reductase
, estradiol 17-beta-dehydrogenase 12
, short chain dehydrogenase/reductase family 12C, member 1
, steroid dehydrogenase homolog
, smooth muscle-specific 17 beta-hydroxysteroid dehydrogenase type 3
, steroid dehydrogenase
, hydroxysteroid (17-beta) dehydrogenase 12
, 17-beta-HSD 12-A
, 17-beta-hydroxysteroid dehydrogenase 12-A
, estradiol 17-beta-dehydrogenase 12-A
, 17-beta hydroxysteroid dehydrogenase type 12A, 3-ketoacyl-CoA reductase type A
, Estradiol 17-beta-dehydrogenase 12-A
, very-long-chain 3-oxoacyl-CoA reductase-A
, zf 3.1