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No significant difference was found in genotype or allele distributions of the polymorphisms rs12529 of HSD17B5 (show AKR1C3 ELISA Kits) and rs898611 of HSD17B6 between patients with PCOS and controls.
the CYP11A1 (show CYP11A1 ELISA Kits), CYP17A1 (show CYP17A1 ELISA Kits), HSD3B2 (show HSD3B2 ELISA Kits), SRD5A2 (show SRD5A2 ELISA Kits), and HSD17B6 mRNA levels in metastases were significantly lower.
data suggest that there is no association of HSD17B6 and HSD17B5 (show AKR1C3 ELISA Kits) variants with the occurrence of polycystic ovary syndrome in the Chinese population
17beta-hydroxysteroid dehydrogenase (show HSD17B7 ELISA Kits) type 6 (17betaHSD6) converts the androgen DHT to the estrogen 3beta-Adiol, and this leads to activation of the ERbeta (show ESR2 ELISA Kits) reporter.
These data suggest that polymorphisms in the HSD17B6 gene are associated with PCOS and key clinical phenotypes of the disorder.
RoDH enzymes are expressed in tissues that have microsomal 3alpha-hydroxysteroid dehydrogenase/epimerase activities
These replication data suggest a role for HSD17B6 in polycystic ovary syndrome
The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist.
, 17-beta-hydroxysteroid dehydrogenase type 6
, 3(alpha->beta)-hydroxysteroid epimerase
, 3(alpha->beta)-hydroxysteroid epimerasel
, 3-alpha->beta-hydroxysteroid epimerase
, 3-hydroxysteroid epimerase
, NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase
, hydroxysteroid (17-beta) dehydrogenase 6 homolog
, oxidative 3-alpha hydroxysteroid dehydrogenase
, oxidative 3-alpha-hydroxysteroid-dehydrogenase
, retinol dehydrogenase
, short chain dehydrogenase/reductase family 9C, member 6
, hydroxysteroid (17-beta) dehydrogenase 9
, hydroxysteroid 17-beta dehydrogenase 9
, oxidative 17 beta hydroxysteroid dehydrogenase type 6
, hydroxysteroid 17-beta dehydrogenase 6