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The complete CDS sequence of the bovine FABGL gene was determined by homology cloning.
The results indicate that aromatase, 17beta-HSD type 7 and 17beta-HSD type 12, but not 17beta-HSD type 1, are commonly expressed in human breast cancer.
transcription in liver is regulated by C/EBPbeta
Expression of the human Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8, in E. coli and the substrate specificity of the expressed protein were examined. The tissue distribution of mRNA expression of the human Ke 6 gene was also studied.
ERalpha is involved in the transcriptional regulation of HSD17B8 gene in response to E2 through its interaction with C/EBPbeta.
Hs17beta-HSD8 and HsCBR4 show a strong genetic interaction in vivo in yeast, where, only if they are expressed together, they rescue the respiratory deficiency and restore the lipoic acid content of oar1Delta cells.
HSD17B8 mRNA is expressed in human skin, at lower levels in face vs arm or hip. HSD17B8 levels are not altered by topical 17-beta-estradiol treatment.
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.
estradiol 17-beta-dehydrogenase 8
, FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like
, FabG-like protein
, estradiol 17 beta-dehydrogenase 8
, 17-beta-HSD 8
, 17-beta-hydroxysteroid dehydrogenase 8
, 3-oxoacyl-[acyl-carrier-protein] reductase
, estrogen 17-oxidoreductase
, testosterone 17-beta-dehydrogenase 8
, protein Ke6
, really interesting new gene 2 protein
, short chain dehydrogenase/reductase family 30C, member 1
, 17-beta-hydroxysteroid dehydrogenase type 8
, Estradiol 17-beta-dehydrogenase 8
, Testosterone 17-beta-dehydrogenase 8