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This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.
UDP glycosyltransferase 1 family, polypeptide A6
, UDP-glucuronosyltransferase 1-6
, UDP glucuronosyltransferase 1 family, polypeptide A5
, UDP glycosyl transferase 1A6
, UDP glucuronosyltransferase 1 family, polypeptide A6
, UDP-glucuronosyltransferase 1-6-like
, UDP-glucuronosyltransferase 1A6
, UDP glucuronosyltransferase 1 family, polypeptide A10
, UDP glucuronosyltransferase 1 family, polypeptide A7
, UDP glucuronosyltransferase 1 family, polypeptide A8
, UDP glucuronosyltransferase 1 family, polypeptide A9
, UDP-glucuronosyltransferase 1 family polypeptide A6s
, UDP-glucuronosyltransferase 1-F
, phenol-metabolizing UDP-glucuronosyltransferase
, P-nitrophenol specific
, P-nitrophenol-specific UDPGT
, UDP glucuronosyltransferase 1A6
, phenol UDP-glucuronosyltransferase