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concentration-to-dose ratio for valproic acid monotherapy were significantly lower for UGT1A6 homozygous variants 541A>G and 552A>C than for the wild type
high activityUGT1A6 genotype is associated with an increased risk for Warthin's tumor
Rs28898617 (UGT1A6, A > G) variation was associated with an increase in NCVPA.
Oxidative stress and histone modifications may promote transcriptional activation of Ugt1a6 and Ugt1a7 genes.
Identified coding variants on UGT1A1 and UGT1A6 genes in association with serum bilirubin level and hyperbilirubinemia risk in elderly subjects.
Results suggest that CYP3A4 changes the catalytic function of the UGT1A subfamily in a UGT isoform-specific manner.
Evaluating the association of UGT1A6 2 Ser7Ala polymorphism with drug response, there was no significant difference in the genotypic distribution between responders and non-responders.
Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children.
Lower adjusted plasma VPA concentrations were also observed in patients with UGT1A6 double heterozygosities than those with single heterozygosity.
UGT1A6 polymorphisms may be used to identify people with increased risk of developing lung cancer
Polymorphism in UDP-glucuronosyltransferase 1A6 is associated with colorectal cancer.
the protective T allele of rs17863783 was found to be associated with increased mRNA expression of UGT1A6.1; study suggests that rs17863783 may protect from bladder cancer by increasing the removal of carcinogens from bladder epithelium by the UGT1A6.1 protein
Dual polymorphisms of UDP glucuronosyl-transferases 1A6 and 1A1 in a patient with Gilbert's syndrome who had persistent hyperserotoninemia that responded to octreotide are reported.
analysis of UGT1A6 variants and aspirin use in a randomized trial of celecoxib for prevention of colorectal adenoma
The percentage of APAP was higher among UGT1A6*1/*1 genotypes, relative to *1/*2 and *2/*2 genotypes (P = 0.045).
development of UGT1A1 and 1A6 was studied in 50 pediatric liver samples; data imply independent regulation of UGT1A1 and 1A6 where activity has matured after 6 months to 1 year
A positive association is found between UGT1A6 genotypes and the occurrence of anti-tuberculosis drug induced hepatic-injury.
evaluated cross-sectionally whether urinary excretion of ASA and its metabolites differed by UGT1A6 genotype and dietary factors shown to induce UGT
Letter: Results suggest that a small breast cancer risk conveyed by UGT1A1 and UGT1A6 variants may be further amplified by the experience of persisting stressful events.
The induction of UGT1A6 by methotrexate alone or in combination with other antineoplastics is reported.
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.
UDP glycosyltransferase 1 family, polypeptide A6
, UDP-glucuronosyltransferase 1 family polypeptide A6s
, UDP-glucuronosyltransferase 1-6
, UDP-glucuronosyltransferase 1-F
, UDP-glucuronosyltransferase 1A6
, phenol-metabolizing UDP-glucuronosyltransferase
, UDP glucuronosyltransferase 1 family, polypeptide A10
, UDP glucuronosyltransferase 1 family, polypeptide A6
, UDP glucuronosyltransferase 1 family, polypeptide A7
, UDP glucuronosyltransferase 1 family, polypeptide A8
, UDP glucuronosyltransferase 1 family, polypeptide A9
, UDP glucuronosyltransferase 1 family, polypeptide A5
, UDP glycosyl transferase 1A6
, UDP-glucuronosyltransferase 1-6-like
, P-nitrophenol specific
, P-nitrophenol-specific UDPGT
, UDP glucuronosyltransferase 1A6
, UDP-glucuronosyltransferase 1-9