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UGT2B10 activity or genotype should be considered when using cotinine as a tobacco exposure biomarker, particularly in populations such as African American with high frequencies of UGT2B10 nonfunctional variants.
Spatial features influence the potency of UGT2B10 inhibition.
UGT2B10 variant allele carriers had increased levels of C-oxidation (P = 0.0099)and all pathways should be considered when characterizing the role of nicotine metabolism on smoking behavior and cancer risk.
CYP2A6 (show CYP2A6 Proteins) and UGT2B10 genotype explain 53% of the variance in oral nicotine glucuronidation. They are also significantly associated with undeuterated (D0) nicotine glucuronidation in individuals smoking ad libitum.
the substrate specificity of UGT2B10, highlighting its preference for tertiary amines with higher affinities and clearance values than those of UGT1A4 and UGT1A3.
UGT2B17 and UGT2B10 play key roles in the glucuronidation of 3HC in the human liver and that functional polymorphisms in UGT2B17 and UGT2B10 are associated with significantly reduced glucuronidation activities against 3HC.
Data show that UGT2B10 predicts MD independently of age, hormone therapy and parity.
Data suggest that UGTs 2B10 and 2B17 play important roles in the glucuronidation of nicotine and suggest that the UGT2B10 codon 67 SNP and the UGT2B17 gene deletion reduce overall glucuronidation rates of nicotine and its major metabolites in smokers.
UGT2B10 genotype influences nicotine metabolism and should be taken into account when characterizing the role of nicotine metabolism on smoking.
Nicotine glucuronidation and UGT2B10 is reported.
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
UDP glycosyltransferase 2 family, polypeptide B28
, UDP glucuronosyltransferase 2B10
, UDP glucuronosyltransferase 2 family, polypeptide B4
, UDP glucuronosyltransferase 2 family, polypeptide B7
, UDP glucuronosyltransferase 2 family, polypeptide B10
, UDP-glucuronosyltransferase 2B10-like
, UDP-glucuronosyltransferase 2B10
, UDPGT 2B10
, UDP glucuronosyltransferase 2 family, polypeptide B34
, UDP glycosyltransferase 2 family, polypeptide B10