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These data can be used to predict variability in the metabolism of UGT2B17 substrates.
Clopidogrel carboxylic acid is metabolized mainly by UGT2B7 (show UGT2B7 Antibodies) and UGT2B4 (show UGT2B4 Antibodies) in the liver and by UGT2B17 in the small intestinal wall.
UGT2B17 was deleted in 64% of children with lymphoblastic malignancy, but in 83% of children with non-lymphoblastic malignancy. UGT2B17 deletion polymorphism may improve the relapse-free rate in children with non-lymphoblastic malignancy.
Study provides the first evidence of null genotype involvement in UGT2B17 as a risk factor for benign prostatic hyperplasia.
the UGT2B15 (show UGT2B15 Antibodies) and UGT2B17 enzymes are transcriptionally regulated by sex hormone signaling in ERalpha (show ESR1 Antibodies)+ breast cancer cells and are highly expressed in a subset of primary breast cancers.
Chronic lymphocytic leukemia patients with high UGT2B17 and LPL (show LCP1 Antibodies) expression have significantly reduced survival.
UGT2B17 contributes to the in-vitro glucuronidation of arctigenin in liver/intestinal microsomes.
GC-C (show GUCY2C Antibodies)-IRMS analysis sensitive to testosterone doping independent of UGT2B17 genotype.
UGT2B17 mismatch has a negative clinical impact in allogeneic HSCT from HLA-identical sibling donors only when a male donor is used.
This descriptive study examines correlations between concentrations of tamoxifen's glucuronide metabolites and genotypes UGT1A4 (show UGT1A4 Antibodies), UGT2B7 (show UGT2B7 Antibodies), UGT2B15 (show UGT2B15 Antibodies) and UGT2B17 in 132 patients with estrogen receptor (show ESR1 Antibodies)-positive breast cancer under treatment with tamoxifen.
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.
, C19-steroid-specific UDPGT
, UDP glycosyltransferase 2 family, member B17
, UDP-glucuronosyltransferase 2B17
, UDP-glucuronyltransferase, family 2, beta-17
, UDP glycosyltransferase 2 family, polypeptide B28
, UDP glucuronosyltransferase 2 family, polypeptide B17
, UDP-glucuronosyltransferase 2B17-like
, 17-beta-hydroxysteroid specific
, 17-beta-hydroxysteroid-specific UDPGT
, UDP glucuronosyltransferase 2 family, polypeptide B5
, UDP glycosyltransferase 2 family, member 3
, UDP-glucuronosyltransferase 2B3 precursor, microsomal
, UDP-glucuronosyltransferase 2B5
, UDPGT 2B17
, UDPGT 2B3
, liver 17 beta-hydroxysteroid UDP-glucuronosyltransferase
, testosterone, dihydrotestosterone, and beta-estradiol specific
, testosterone, dihydrotestosterone, and beta-estradiol-specific UDPGT