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Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN413086
Riesco, Valcarce, Alfonso, Herráez, Robles: In vitro generation of zebrafish PGC-like cells. in Biology of reproduction 2014
Vrtn binds a bmp2b regulatory sequence and acts as a repressor to inhibit its zygotic transcription.
Study found that BMP-2 is negatively regulated by miR (show MYLIP Proteins)-140 during early embryogenesis and bone development in zebra fi sh.
Data show that transcription of organizer-specific bone morphogenetic protein 2b (bmp2b) is directly down-regulated by Nodal and up-regulated by Wnt (show WNT2 Proteins) signal.
Structures of Bmp2a (show BMP2 Proteins), Bmp2b, Bmp4 and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved.
FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 transcription, and activation of bmp antagonists, nog2 and grem1a (show GREM1 Proteins).
Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development.
BMP2b signaling in zebrafish embryos substantially decreases emergence of lymphatic endothelial cells.
Data show that BMP2B protein is expressed in a gradient as early as blastula stages.
we identify a previously unappreciated role for the Nodal-transcription factor FoxH1 in mediating cell responsiveness to Bmp further linking the control of these two pathways in the heart
The Bmp2b mutants and mosaic loss-of-function experiments reveal that BMP acts as a repressor of eye-field fate through inhibition of its key transcription factor Rx3, thereby protecting the future telencephalon from acquiring eye identity.
Data indicate that bone morphogenetic protein (BMP) signaling is essential for erythroid differentiation, and in the absence of BMP signaling, precursor cells adopt an endothelial cell (EC) fate.
Osr1 (show OSR1 Proteins)/Osr2 normally repress bmp4 expression in the lateral plate mesoderm prior to respiratory specification.
The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4.
PIAS (show PIAS1 Proteins) proteins have differential ability to regulate signals from the growth factors activin, bone morphogenetic protein 4 (BMP4), and Wnt8 (show WNT8A Proteins).
Data show that PV.1A undergoes combinatorial regulation during early Xenopus development as both the direct target of BMP-4 signaling and as the direct and indirect target of positive and negative regulatory factors.
BMP inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.
Data suggest that the feedback inhibitors BAMBI (show BAMBI Proteins), SMAD6 (show SMAD6 Proteins), and SMAD7 (show SMAD7 Proteins) expand the dynamic BMP4 signaling range essential for proper embryonic patterning and reduce interindividual phenotypic and molecular variability in Xenopus embryos.
limits homeobox (show PRRX1 Proteins) gene expression in the organiser/non-organiser direction
X-epilectin expression is down-regulated by Noggin (show NOG Proteins) and tBR and that this effect is inhibited by BMP4 over-expression
BMP4-dependent expression of Xenopus Grainyhead-like 1 (show GRHL1 Proteins) has a critical role in epidermal differentiation
BMP4 signaling plays a role in the regulation of terminal differentiation of primary equine trophoblast cells via activation of the SMAD1 (show SMAD1 Proteins)/5 pathway
results indicate that the BMP4 rs17563 variant is likely to confer a protective effect against the occurrence of Non-Syndromic Cleft Lip with or without Cleft Palate in a sample of the southeast Iranian population.
cardiomyocyte (CM) conditioned medium can trigger the recruitment of pro-inflammatory (M1) macrophages, through a mechanism that involves, in part, CM-derived BMP4.
BMP4 participates in the regulation of invasion and migration by EC109/Taxol cells
Bone morphogenetic protein 4 regulates expression of microRNAs miR (show MLXIP Proteins)-494 and miR (show MLXIP Proteins)-126-5p to control endothelial cell function in angiogenesis.
BMP4 expression was significantly increased in HCC (show FAM126A Proteins) tissue, and was correlated with tumor de-differentiation and unfavorable prognosis. BMP4 promoted HCC (show FAM126A Proteins) EMT (show ITK Proteins) and was correlated with OXA resistance.
Gene expression profiling showed that MuSK (show MUSK Proteins) was required for the BMP4-induced expression of a subset of genes in myoblasts, including regulator of G protein signaling 4 (Rgs4 (show RGS4 Proteins)).
BMP4 levels are increased dramatically in individuals with impaired glucose tolerance and type 2 diabetes.
The results suggest that selective RNA decay via TGF-beta (show TGFB1 Proteins) and BMP4 signaling is critical for specifying the developmental fate of specific human embryonic cell lineages.
Expression of bone morphogenetic protein (BMP) 4, an upstream stimulator of SOX9, was upregulated by CG.
Study shows that BMP4 is overexpressed in hepatocellular carcinoma (HCC (show FAM126A Proteins)) tissues and BMP4-induced ID2/CDKN1B (show CDKN1B Proteins) signaling facilitates the proliferation of HCC (show FAM126A Proteins).
differentiated cells exhibited contracting masses. These results suggest that BMP4-mediated somatic stem cell reprogramming may become an alternative approach for cell therapy
Bmp4 promotes a brown to white-like adipocyte shift.
results suggest that bone morphogenetic protein 4 promotes the generation of male germ cells from induced pluripotent stem (iPS (show SLC27A4 Proteins)) cells
These results suggest how BMP4 regulates adipocyte recruitment in subcutaneous (SC) white adipose tissue, and thus promote its beneficial metabolic effects.
RUNX1T1 (show RUNX1T1 Proteins) serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells
Expression of Bmp4 in the ureteric mesenchyme depends on HH signaling and Foxf1 (show FOXF1 Proteins), and that exogenous BMP4 rescued cell proliferation and epithelial differentiation in ureters with abrogated HH signaling or FOXF1 (show FOXF1 Proteins) function.
the effect of titanium (Ti) with nanotopography (Nano) on the endogenous expression of BMP-2 (show BMP2 Proteins) and BMP-4 and the relevance of this process to the nanotopography-induced osteoblast differentiation.
These data indicate that Foxc1 (show FOXC1 Proteins) expression is regulated by BMP4 and FOXC1 (show FOXC1 Proteins) functions in the commitment of progenitor cells to the osteoblast fate and its expression is reduced when differentiation proceeds.
Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level.
High BMP4 expression is associated with cystic ovarian disease.
Bone morphogenetic protein 4 and retinoic acid trigger bovine VASA homolog (show DDX4 Proteins) expression in differentiating bovine induced pluripotent stem cells.
The BMP2/4 ligand and receptor system presides within bovine trophectoderm prior to uterine attachment. BMP4 negatively impacts CT1 (show SLC6A8 Proteins) cell growth
BMP4 during maturation increased the proportion of Oct-4 (show POU5F1 Proteins) positive cells in parthenogenic embryos. BMP4 is implicated in bovine oocytes maturation and embryo development.
analysis of polymorphic CA microsatellites in the third exon of the bovine BMP4 gene
concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than in oocyte maturation
Data report that BMP-7 (show BMP7 Proteins) suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD (show DFFB Proteins)) via a mechanism which does not appear to be associated with the mitochondrial pathway, whereas BMP-4 inhibits the release of CAD.
Heat shock protein 70 (show HSP70 Proteins) enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein (show MGP Proteins).
A microsatellite (ACn (show ACIN1 Proteins)) was identified in the 3' UTR of BMP4 gene.Prolificacy associated microsatellite (AC19 (show POLR1D Proteins)) was detected in Indian goats.
paracrine signals from the embryo, represented by FGF4 (show FGF4 Proteins) and BMP4, induce a response in the trophoblast prior to the extensive elongation.
The structure of porcine BMP4 gene is highly conservative with other mammalian BMP4 genes, but some differences may be present in the regulation of gene expression.
Altered shear stress stimulates upregulation of endothelial VCAM-1 (show VCAM1 Proteins) and ICAM-1 (show ICAM1 Proteins) in a BMP-4- and TGF-beta1 (show TGFB1 Proteins)-dependent pathway.
The TM-induced characteristic changes in the expression pattern of Hoxa11 (show HOXA11 Proteins) and Bmp4 on GDs (show PAEP Proteins) 10 and/or 11 were not noted.
BMP4 is expressed peripherally in hypoblast and epiblast and in the mesoderm at the posterior pole of the embryonic disc.
Data show that BMP-2 (show BMP2 Proteins), BMP-4, and BMP-7 (show BMP7 Proteins), noggin (show NOG Proteins), and chordin (show CHRD Proteins) were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.
Both of the adenovirus-containing bone morphogenetic protein transduced MSCs expressed BMP4 mRNA and protein and underwent osteogenic differentiation.
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
, bone morphogenetic protein-4
, bone morphogenetic protein 4
, bone morphogenetic protein 4, isoform 3
, Bone morphogenetic protein 4
, bone morphogenetic protein 4-like
, bone morphogenetic protein 2
, bone morphogenetic protein 2B