Browse our anti-Ataxin 1 (ATXN1) Antibodies

Full name:: anti-Ataxin 1 Antibodies (ATXN1)

On www.antibodies-online.com are 242 Ataxin 1 (ATXN1) Antibodies from 25 different suppliers available. Additionally we are shipping Ataxin 1 Kits (34) and Ataxin 1 Proteins (8) and many more products for this protein. A total of 296 Ataxin 1 products are currently listed.

Synonyms:: 2900016G23Rik, ataxin 1b, Atx1, atxn1, C85907, CG4547, D6S504E, dAtx-1, dAtx1, Dmel\\CG4547, ENSMUSG00000074917, Gm10786, sca1

list all antibodies	Gene Name	GeneID	UniProt
	ATXN1	6310	P54253
	ATXN1	20238	P54254
	ATXN1	25049	Q63540
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anti-Human Ataxin 1 Antibodies:

anti-Mouse (Murine) Ataxin 1 Antibodies:

anti-Rat (Rattus) Ataxin 1 Antibodies:

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Top referenced anti-Ataxin 1 Antibodies

Mammalian Monoclonal Ataxin 1 Primary Antibody for ISt, IHC - ABIN1304546 : Menon, Nethisinghe, Faggiano, Vannocci, Rezaei, Pemble, Sweeney, Wood, Davis, Pastore, Giunti: The role of interruptions in polyQ in the pathology of SCA1. in PLoS genetics 2013 (PubMed)
Human Monoclonal Ataxin 1 Primary Antibody for ELISA, FACS - ABIN968970 : Lim, Crespo-Barreto, Jafar-Nejad, Bowman, Richman, Hill, Orr, Zoghbi: Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. in Nature 2008 (PubMed)
Dog (Canine) Polyclonal Ataxin 1 Primary Antibody for ELISA - ABIN4254772 : Banfi, Servadio, Chung, Kwiatkowski, McCall, Duvick, Shen, Roth, Orr, Zoghbi: Identification and characterization of the gene causing type 1 spinocerebellar ataxia. in Nature genetics 1994 (PubMed)

More Antibodies against Ataxin 1 Interaction Partners

Human Ataxin 1 (ATXN1) interaction partners

SCA1 mutation carriers performed similarly to controls in the postural tasks with open eyes, whereas in conditions without visual feedback SCA1 carriers had significantly higher stability index than controls at all longitudinal evaluations. Close-to-disease onset carriers (
In cervical cancer cells, ATXN1 knockdown induced EMT by directly regulating Snail expression, leading to matrix metalloproteinase activation and the promotion of cell migration and invasion.
ATXN1 underexpression is associated with metabolic diseases.
data suggest GSK3b and mTOR (show FRAP1 Antibodies) pathways modulate this ATXN1 function in spinocerebellar ataxia type-1 (SCA1)pathogenesis that could be targeted therapeutically prior to the onset of disease symptoms in SCA1 and other pathologies involving dysregulation of ATXN1 functions.
SCA1 phenotypes could be reversed by partial suppression of human mutant ATXN1 mRNA by rAAV.miS1 when delivered after symptom onset in mice.
SCA1 relative frequency in Poland shows the highest value compared with the data from other countries worldwide in patient with Spinocerebellar ataxias
Studied Ataxin-1 using molecular modeling to investigate the protein-protein interactions contributing to the AXH domain dimer stability.
Data indicate that in spinocerebellar ataxia type 1 patients the spinocerebellar ataxia type 1 protein trinucleotide repeat expansion (CAG)n was great than 39, comparing with normal 6-38.
This study reports the results of molecular dynamics simulations of AXH monomer of Ataxin-1.
Systematic replacement of each lysine residue in the AXH domain revealed that the lysine at 589 (K589) of ATXN1 is essential for its ubiquitylation by UbcH6 (show UBE2E1 Antibodies).

Mouse (Murine) Ataxin 1 (ATXN1) interaction partners

data suggest GSK3b and mTOR (show FRAP1 Antibodies) pathways modulate this ATXN1 function in spinocerebellar ataxia type-1 (SCA1)pathogenesis that could be targeted therapeutically prior to the onset of disease symptoms in SCA1 and other pathologies involving dysregulation of ATXN1 functions.
Maternal diabetes induced caspase 3 (show CASP3 Antibodies)-dependent apoptosis in Sca1(+) cardiac progenitor cells derived from embryonic day 17.5 (E17.5). Both maternal diabetes and high glucose in vitro activated the pro-apoptotic transcription factor, Forkhead O 3a (FoxO3a (show FOXO3 Antibodies)) via dephosphorylation at threonine 32 (Thr (show TRH Antibodies)-32) residue.
Data establish a novel role for ATXN1 in the hippocampus as an intrinsic regulator of precursor cell proliferation, and suggest a mechanism by which polyQ expansion and loss of ATXN1 affect hippocampal function, potentially contributing to cognitive deficits and depression
The results of this study found that upregulation of cholecystokinin (Cck (show CCK Antibodies)) and subsequent interaction with the Cck1 (show CCL28 Antibodies) receptor likely underlies the lack of progressive Purkinje cell pathology in Pcp2-ATXN1[30Q]D776 mice.
Mutant ATXN1 forms oligomers whose levels correlate with disease progression in the Atxn1154Q/+ mice.
The study showed that Sca1(+)Lin(-) bone marrow contains an endodermal precursor population of cells that differentiates into hepatocytes.
HMGB1 (show HMGB1 Antibodies) facilitates repair of mitochondrial DNA damage of mutant ataxin-1 knock-in mice.
The RNA-binding protein PUMILIO1 (PUM1 (show PUM1 Antibodies)) not only directly regulates ATAXIN1 but also plays an unexpectedly important role in neuronal function. Loss of Pum1 (show PUM1 Antibodies) caused progressive motor dysfunction and SCA1-like neurodegeneration with motor impairment, primarily by increasing Ataxin1 levels.
study found a new function of ataxin-1: the modulation of Pp2a activity and the regulation of its holoenzyme composition, with the polyglutamine mutation within Atxn1 altering this function in the spinocerebellar ataxia type 1 mouse cerebellum before disease onset
Delivery of either ataxin-1-like viral vectors to Spinocerebellar Ataxia Type 1 mice cerebella resulted in widespread cerebellar Purkinje cell transduction

Fruit Fly (Drosophila melanogaster) Ataxin 1 (ATXN1) interaction partners

Ataxin-1 induces intranuclear accumulation of dAtx2/hAtaxin-2 in both Drosophila and SCA1 postmortem neurons
mutant ataxin-1 and huntingtin (show HTT Antibodies) induce developmental and late-onset neuronal pathologies in Drosophila models

Ataxin 1 (ATXN1) Antigen Profile

Antigen Summary

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Ataxin 1 (ATXN1)

ataxin 1 (ATXN1) antibody
ataxin 1b (atxn1b) antibody
ataxin 1 (Atxn1) antibody
Ataxin 1 (Atx-1) antibody
ataxin 1 like (ATXN1L) antibody

2900016G23Rik antibody
ataxin 1b antibody
Atx1 antibody
atxn1 antibody
C85907 antibody
CG4547 antibody
D6S504E antibody
dAtx-1 antibody
dAtx1 antibody
Dmel\\CG4547 antibody
ENSMUSG00000074917 antibody
Gm10786 antibody
sca1 antibody

Protein level used designations for anti-Ataxin 1 (ATXN1) Antibodies

ataxin-1 , spinocerebellar ataxia type 1 protein , ataxin 1 , spinocerebellar ataxia type 1 , spinocerebellar ataxia 1 homolog , spinocerebellar ataxia 1 , spinocerebellar ataxia type 1 protein homolog , Ataxin1 , Atx-1-PB , CG4547-PB , spinocerebellar ataxia type 1 protien , ataxin-1-like

GENE ID	SPECIES
6310	Homo sapiens
747421	Pan troglodytes
100065748	Equus caballus
565841	Danio rerio
616399	Bos taurus
420843	Gallus gallus
493678	Felis catus
20238	Mus musculus
25049	Rattus norvegicus
31624	Drosophila melanogaster
488232	Canis lupus familiaris
100025666	Monodelphis domestica
100402564	Callithrix jacchus
100437511	Pongo abelii
100467930	Ailuropoda melanoleuca
100154571	Sus scrofa
100588152	Nomascus leucogenys
489725	Canis lupus familiaris
101113284	Ovis aries
101787379	Cavia porcellus

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