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anti-Human CHRM3 Antibodies:
anti-Rat (Rattus) CHRM3 Antibodies:
anti-Mouse (Murine) CHRM3 Antibodies:
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Mouse (Murine) Polyclonal CHRM3 Primary Antibody for IF (p), IHC (p) - ABIN674484
Chen, Li, Zhang, Zhai, Gong, Qiang, Xue: An ENU-induced mutation of Nrg1 causes dilated pupils and a reduction in muscarinic receptors in the sphincter pupillae. in PLoS ONE 2011
Show all 3 Pubmed References
Human Polyclonal CHRM3 Primary Antibody for ELISA, WB - ABIN560365
Cheng, Cao, Zheng, Wang, Sun, Liu, Zhang, Wang, Zhu, Wu: Airway hyperresponsiveness induced by repeated esophageal infusion of HCl in guinea pigs. in American journal of respiratory cell and molecular biology 2014
Show all 2 Pubmed References
Human Polyclonal CHRM3 Primary Antibody for IHC (p) - ABIN4336799
Stoffel, Monnard, Steiner, Mevissen, Meylan: Distribution of muscarinic receptor subtypes and interstitial cells of Cajal in the gastrointestinal tract of healthy dairy cows. in American journal of veterinary research 2006
Show all 2 Pubmed References
Human Polyclonal CHRM3 Primary Antibody for IHC (p) - ABIN2475761
Billington, Penn: m3 muscarinic acetylcholine receptor regulation in the airway. in American journal of respiratory cell and molecular biology 2002
Human Polyclonal CHRM3 Primary Antibody for IHC, IHC (p) - ABIN4336801
Molina, Rodriguez-Diaz, Fachado, Jacques-Silva, Berggren, Caicedo: Control of insulin secretion by cholinergic signaling in the human pancreatic islet. in Diabetes 2014
These results indicate that not H1 but M3 receptor-induced activation of p38 MAPK (show MAPK14 Antibodies) might contribute to the maintenance of epithelial barrier function through down-regulation of TNF-alpha (show TNF Antibodies) signalling and activation of EGFR (show EGFR Antibodies).
Morphine-induced MOP receptor (show OPRM1 Antibodies) endocytosis is facilitated by concurrent M3 activation.M3 and MOP (show NLN Antibodies) assemble in receptor heterocomplexes mainly located at the plasma membrane.M3-MOP receptor (show OPRM1 Antibodies) pharmacological interaction is independent of heterocomplex formation.M3 and MOP receptor (show OPRM1 Antibodies) heteromers disrupt upon both receptor endocytosis.
this study shows that anti-M3R (show CHRM4 Antibodies) is significantly elevated in Sjogren's syndrome plasma in comparison with rheumatoid arthritis, systemic lupus erythematosus, and healthy controls
Interacting post-muscarinic receptor (show CHRM5 Antibodies) signaling pathways potentiate MMP1 (show MMP1 Antibodies) expression and invasion of human colon cancer cells.
M3R (show CHRM4 Antibodies) expression plays an important role in early progression and invasion of colon neoplasia but is less important once tumors have spread.
This study presents the endocytic pathways of internalization for muscarinic type 3 receptor and flotillin-1 (show FLOT1 Antibodies)/2 in salivary gland epithelial cells. knockdown of flot-1 (show FLOT1 Antibodies) or -2 by flotillin (show FLOT2 Antibodies)-specific siRNA prevented internalization and reduced the endocytic efficiency of muscarinic type 3 receptor.
M3-mAChR activation leads to enhancement of hsp expression via PKC (show PRRT2 Antibodies)-dependent phosphorylation of HSF1 (show HSF1 Antibodies), thereby stabilizing the mutant hERG (show KCNH2 Antibodies)-FLAG protein. Thus, M3-mAChR activators may have a therapeutic value for patients with LQT2 (show KCNH2 Antibodies).
There were no significant associations between CHRM3 SNPs and autonomic nervous system activity in patients with schizophrenia on high-dose antipsychotics.
To our knowledge, this is the first genetic association study that reveals the genetic contribution of CHRM3 gene in bladder cancer etiology.
The CHRM3 gene plays a role in abnormal thalamo-orbital frontal cortex functional connectivity in first-episode treatment-naive patients with schizophrenia.
Data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp (show CLASRP Antibodies) and sling fibers similar to human clasp (show CLASRP Antibodies) and sling fibers.
Sequential activation of muscarinic M3 receptors and cannabinoid CB1 (show CNR1 Antibodies) receptors produce synergistic contractile effects of the bovine ciliary muscle by involving the activation of Rho-kinase (show ROCK1 Antibodies) and protein kinase C (show PKC Antibodies).
These data support the existence of a novel transducing cascade, involving Galpha (show SUCLG1 Antibodies)(q16)beta gamma coupling M(3)AChR to NPR (show NPTXR Antibodies)-GC.
airway M(2)Rs inhibit BK channels by a dual, Gbetagamma-mediated mechanism, a direct membrane-delimited interaction, and the activation of the phospholipase C (show PLC Antibodies)/protein kinase C (show PKC Antibodies) pathway
Stimulation of the ERK (show EPHB2 Antibodies) pathway in Gnb5 (show GNB5 Antibodies)(-/-) cells by epidermal growth factor (show EGF Antibodies) restored M3R-stimulated insulin (show INS Antibodies) release to near normal levels. Identification of the novel role of Gbeta5 (show GNB5 Antibodies)-R7 in insulin (show INS Antibodies) secretion may lead to a new therapeutic approach for improving pancreatic beta-cell function
s. Moreover, we found that M3 cholinergic receptor (CHRM3) was upregulated in a large subset of benign prostatic hyperplasia (BPH (show GLI3 Antibodies)) tissues compared with normal tissues. Activation of CHRM3 also promoted the proliferation of BPH (show GLI3 Antibodies) cells.
early intervention with cholinergic receptor muscarinic (ChRM)-3 blocker reversed the progression of airway hyperreactivity in the neonatal exposure model, whereas beta2-adrenoceptor agonists had no such effect
Arthritis-induced joint destruction was significantly stronger in mice with M3 muscarinic acetylcholine receptor deficiency.
The effects of muscarinic receptor (show CHRM5 Antibodies) M3 knockout on cathepsin K (show CTSK Antibodies) expression, bone density and biomechanical properties of bone are reported.
results suggest that the autoantibodies against peptides of the second extracellular loop of M3R are not pathogenic in vivo and they are not suitable as biomarkers for pSS (show CDSN Antibodies) diagnosis
Expression of the M3 receptors mediating cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras (show MRAS Antibodies)-/- males and females, although only males exhibited a urinary phenotype.
The study screened CrkL (show CRKL Antibodies) binding proteins using RNA interference (RNAi) and identified Sorbs1 (show SORBS1 Antibodies) and Sorbs2 (show Sorbs2 Antibodies) as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro.
Activation of Chrm3 inhibits the recruitment of beta-arrestin-2 (show ARRB2 Antibodies) to odorant receptors, resulting in a potentiation of odor-induced responses in olfactory sensory neurons.
The muscarinic M3R receptor interacts directly with NOSTRIN (show NOSTRIN Antibodies) at the plasma membrane in the aorta.
G-protein coupled receptor, muscarinic receeptor subtype that mediates cholinergic-induced contraction in most smooth muscle
m3 muscarinic acetylcholine receptor
, muscarinic acetylcholine receptor M3
, cholinergic receptor, muscarinic 3
, acetylcholine receptor, muscarinic 3
, m3 muscarinic receptor
, cholinergic receptor, muscarinic 3, cardiac
, M3 muscarinic acetylcholine receptor
, AChR M3
, mm3 mAChR
, muscarinic acetylcholine receptor 3