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The rs13180 (IREB2 (show IREB2 Proteins)), rs16969968 (CHRNA5 (show CHRNA5 Proteins)) and rs1051730 (CHRNA3) were significantly associated with Chronic obstructive pulmonary disease (COPD (show ARCN1 Proteins)) in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47]. The C-G haplotype by rs13180 and rs1051730 was a protective factor for COPD (show ARCN1 Proteins) in our population (Padj =0.0005, OR=0.61).
our results show that a genomic region with functionally related genes, such as the CHRNA5/CHRNA3/CHRNB4 cluster, is under coordinated regulatory control.
CHRNA3 genetic risk score was associated with successful smoking cessation in a Chinese rural population.
The minor allele increased the risk of COPD (show ARCN1 Proteins) when compared to the population at large. Homozygosity for the risk allele was associated in both cohorts with all-cause mortality, with any type of cancer among the COPD (show ARCN1 Proteins) patients and with the number of pack-years among the male smokers.
The results of this study suggests a pleiotropic role of Chr15q25 CHRNA5-CHRNA3-CHRNB4 gene cluster with complex influences in ADHD, tobacco smoking and cognitive performance.
both rs578776 and rs938682 of CHRNA3 were significantly associated with the susceptibility of lung cancer.
the association of 3 selected single-nucleotide polymorphisms (CHRNA3 rs1051730, rs6495308, and CHRNA5 rs55853898) with nicotine dependence in an isolated population of Kashubians from Poland, is reported.
CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers.
focus on the CHRNA5/A3/B4 gene cluster and its role in nicotine dependence (review)
At CHRNA3, allele G of rs3743078 was associated with increased nicotine craving.
neuroinflammation is sufficient to provoke the decrease of a7 and a4b2 nAChRs, Ab42 accumulation and memory impairment in mice and a7(1-208) nAChR (show CHRNA4 Proteins)-specific antibodies can cause inflammation of the brain with symptoms typical for Alzheimer disease
The alpha3beta4* nicotinic ACh (show FGFR3 Proteins) receptor subtype mediates physical dependence to morphine
The present findings suggest that its thymic production and/or release are under cholinergic control involving nAChR (show CHRNA4 Proteins) containing the alpha3-subunit.
Downregulation of nAChR (show CHRNA4 Proteins) subunit and PSD-93 (show DLG2 Proteins) expression after cavernous nerve injury, or even manipulation, could interrupt synaptic transmission within the MPG (show MPG Proteins) and thus contribute to the loss of neural control of urogenital organs after pelvic surgeries.
findings suggest an important role for the a3b4* nAChR (show CHRNA4 Proteins) subtype in nicotine reward and physical aspects of the nicotine withdrawal syndrome.
Greater expression of Chrna3 is found in whole brain and dissected brain regions relevant to locomotor behavior in mice that are less sensitive to ethanol-induced stimulation compared to mice that are robustly stimulated.
Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles.
The results of this study demonstrated that hyperglycemia also interferes with the function of alpha3-containing nAChRs through Cys (show DNAJC5 Proteins) residues on the alpha3 subunit
functional nicotinic ACh (show FGFR3 Proteins) receptors are detected on stem and progenitor cells of fetal mouse cerebral cortex as early as embryonic day 10
Our results suggest that PrP(C (show PRNP Proteins)) is a member of a multiprotein membrane complex participating in the formation and function of alpha3beta4 nAChR (show CHRNA4 Proteins).
Data show that a basic residue at position 210 of alpha3 subunit decreases the assembly of heteromeric neuronal alpha3beta4 nicotinic ACh (show FGFR3 Proteins) receptors.
Sympathetic alpha3beta2-nAChRs (CHRNA3/CHRNB2) mediate basilar artery neurogenic nitrergic vasodilation in swine.
This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.
cholinergic receptor, nicotinic, alpha polypeptide 3
, neuronal acetylcholine receptor subunit alpha-3
, neuronal nicotinic acetylcholine receptor, alpha3 subunit
, neuronal acetylcholine receptor subunit alpha-3-like
, cholinergic receptor, nicotinic, alpha 3
, alpha 3
, neuronal nicotinic acetylcholine receptor, alpha 3 subunit
, Acetylcholine receptor alpha 3 (neuronal nicotine)
, cetylcholine receptor alpha 3 (neuronal nicotine)
, cholinergic receptor nicotinic alpha polypeptide 4
, neuronal nicotinic acetylcholine receptor subunit 3