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Human Polyclonal CPEB1 Primary Antibody for ELISA, WB - ABIN250242
Nairismägi, Vislovukh, Meng, Kratassiouk, Beldiman, Petretich, Groisman, Füchtbauer, Harel-Bellan, Groisman: Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression. in Oncogene 2012
Show all 3 Pubmed References
Human Polyclonal CPEB1 Primary Antibody for ELISA, WB - ABIN4300227
Richter: CPEB: a life in translation. in Trends in biochemical sciences 2007
Show all 2 Pubmed References
c-mos (show MOS Antibodies) mRNA localizes with Zorba around the animal pole in the zebrafish oocyte suggesting that the animal cortex is the central core of oocyte maturation in zebrafish.
Upon binding to p27(Kip1 (show CDKN1B Antibodies)) 3'UTR (show UTS2R Antibodies), CPEB1 promotes elongation of poly-A tail and the subsequent translation of p27(Kip1 (show CDKN1B Antibodies)) mRNA. This leads to higher levels of p27(Kip1 (show CDKN1B Antibodies)) in the cell, in turn significantly inhibiting cell proliferation, and confers to CPEB1 a potential value as a tumor suppressor in Glioblastoma.
CPEB1 regulation of MMP9 (show MMP9 Antibodies) mRNA expression mediates metastasis of breast cancer cells
The host RNA-binding protein (show PTBP1 Antibodies) CPEB1 was highly induced after cytomegalovirus infection and ectopic expression of CPEB1 in non-infected cells recapitulated infection-related post-transcriptional changes. CPEB1 was also required for poly(A)-tail lengthening of viral RNAs important for productive infection.
Expression levels of CPEB4 and CPEB1 genes are correlated with overall survival in patients with glioma.
WEE1 (show WEE1 Antibodies) is regulated at the translational level by CPEB1 and miR (show MLXIP Antibodies)-15b in a coordinated and cell-cycle-dependent manner.
This mechanical catalysis makes possible a positive feedback loop that would help localize the formation of CPEB fibers to active synapse areas and mark those synapses for forming a long-term memory after the prion form is established. The functional role of the CPEB helical oligomers in this mechanism carries with it implications for targeting such species in neurodegenerative diseases.
Structural Analysis of the Pin1 (show PIN1 Antibodies)-CPEB1 interaction and its potential role in CPEB1 degradation has been described.
Identify a mechanism of VEGF overexpression in liver and mesentery that promotes pathologic, but not physiologic, angiogenesis, via sequential and nonredundant functions of CPEB1 and CPEB4.
CPEB1, 2, and 4, are essential to successful mitotic cell division.
Results suggest that CPEB1-mediated translational control is essential for the differentiation of GSCs.
CPEB1 level was increased in the basolateral amygdala (BLA (show LACTB Antibodies)) of model mice injected with Complete Freund's Adjuvant. CPEB1 knockdown in the BLA (show LACTB Antibodies) can relieve anxiety-like behaviors but not pain-like behaviors by heightening inhibitory transmission and restoring the excitatory/inhibitory balance in model mice.
DAZL (show DAZL Antibodies) and CPEB1 regulate mRNA translation during oocyte maturation.
cytoplasmic-element-binding control of transforming growth factor beta-activated kinase 1 (show MAP3K7 Antibodies) mRNA translation mediates the inflammatory immune response
Myoepithelial cells prevent EMT (show ITK Antibodies) by influencing the polarity and proliferation of luminal epithelial cells in a mechanism that requires translational silencing of myoepithelial Twist1 (show TWIST1 Antibodies) by CPEB1.
Fmr1 (show FMR1 Antibodies)(-/y); Cpeb1(-/-) double-knockout mice displayed amelioration of biochemical, morphological, electrophysiological and behavioral phenotypes associated with fragile X (show FMR1 Antibodies) syndrome.
poly(A) polymerase (show PAPOLA Antibodies) Gld2 (show PAPD4 Antibodies), deadenylase PARN (show PARN Antibodies), and translation inhibitory factor neuroguidin (Ngd (show NGDN Antibodies)) are components of a dendritic CPEB-associated polyadenylation apparatus
CPEB-mediated zonal occludens-1 mRNA localization is essential for tight-junction assembly and mammary epithelial cell polarity
when the Cpeb1 knockout mice were fed a high-fat diet, their livers became insulin (show INS Antibodies)-resistant.Our results show that Cpeb1 regulated translation is a key process involved in insulin (show INS Antibodies) signaling
CPEB, localized in oocyte cytoplasm, was hyperphosphorylated during prophase/metaphase-I transition.
Aurora kinase A (show AURKA Antibodies) is unlikely to be involved in CPEB1 activating phosphorylation and cyclin B1 (show CCNB1 Antibodies) mRNA polyadenylation during meiotic maturation of porcine oocytes.
results suggest the involvement of mammalian CPEB1 in Cyclin B syntheses and meiotic resumption in mammalian oocytes
This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene.
cytoplasmic polyadenylation element binding protein 1
, CPE-binding protein 1
, cytoplasmic polyadenylation element-binding protein 1
, cytoplasmic polyadenylation element-binding protein 1-like
, Orb/CPEB-related RNA-binding protein
, protein Zorba
, zebrafish orb-type a
, CPEB-related RNA binding protein