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A significant GABRG1 genotype influences self-administration of alcohol and GABAergic manipulation.
we genotyped 13 single nucleotide polymorphisms spanning GABRG1 and GABRA2 (show GABRA2 Antibodies) in African Americans with alcohol dependence
An intronic single nucleotide polymorphism (SNP) (rs17536211) in GABRG1 shows the strongest statistical evidence of association of recovery from eating disorders.
A single nucleotide polymorphism of the GABRG1 gene (rs1497571) is associated with level of response to alcohol and drinking patterns.
Logistic regression analysis indicated that genetic elements in the GABRG1 haplotype block likely contribute to alcohol dependence risk in an additive manner.
study of patterns of htSNPs & linkage disequilibrium (LD)in 6 populations; LD extended from most of the GABRA2 (show GABRA2 Antibodies) gene through the GABRG1 locus in the same GABAA cluster region suggesting possible association of these genes with alcohol dependence
it is concluded that the anxiolytic-like activities of rubimetide and typical agonist peptides of the FPR2 were mediated successively by the PGD2-DP1 receptor, adenosine-A2A receptor, and GABA-GABAA receptor systems downstream of the FPR2.
A single nucleotide polymorphism (SNP) at the nucleotide position 462 (C/G) in the b1 sequence of the GABAA reseptor was found. This SNP was observed in 5 mice from the sensitive strain and in 36 mice from the resistant strain. The Fischer exact test was used to compare two strains of mice for SNP in the cDNA sequence of the b1 subunit
Hypnotic activity of melatonin may be mediated through picrotoxin site on GABAA receptor.
Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 (show PTGER3 Antibodies) receptors
A mutated axJ gene locus, encoding the ubiquitin-specific protease 14 (Usp14), negatively influences GABAA receptor turnover.
The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4.
gamma-aminobutyric acid A receptor, gamma 1
, GABA(A) receptor subunit gamma-1
, gamma-aminobutyric acid receptor subunit gamma-1
, GABA(A) receptor, gamma
, gamma-1 polypeptide
, gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 1